New insights into anti-depression effects of bioactive phytochemicals
Depression is one of the most common psychological disorders, and due to its high prevalence and mortality rates, it imposes a significant disease burden. Contemporary treatments for depression involve various synthetic drugs, which have limitations such as side effects, single targets, and slow ons...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661824005115 |
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| author | Ruohan Zhao Jingwen Wang Sookja Kim Chung Baojun Xu |
| author_facet | Ruohan Zhao Jingwen Wang Sookja Kim Chung Baojun Xu |
| author_sort | Ruohan Zhao |
| collection | DOAJ |
| description | Depression is one of the most common psychological disorders, and due to its high prevalence and mortality rates, it imposes a significant disease burden. Contemporary treatments for depression involve various synthetic drugs, which have limitations such as side effects, single targets, and slow onset of action. Unlike synthetic medications, phytochemicals offer the benefits of a multi-target and multi-pathway mode of treatment for depression. In this literature review, we describe the pharmacological actions, experimental models, and clinical trials of the antidepressant effects of various phytochemicals. Additionally, we summarize the potential mechanisms by which these phytochemicals prevent depression, including regulating neurotransmitters and their receptors, the HPA axis, inflammatory responses, managing oxidative stress, neuroplasticity, and the gut microbiome. Phytochemicals exert therapeutic effects through multiple pathways and targets, making traditional Chinese medicine (TCM) a promising adjunctive antidepressant for the prevention, alleviation, and treatment of depression. Therefore, this review aims to provide robust evidence for subsequent research into developing phytochemical resources as effective antidepressant agents. |
| format | Article |
| id | doaj-art-f58167c9b958457bbb49cdda63d0bbf4 |
| institution | Kabale University |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-f58167c9b958457bbb49cdda63d0bbf42025-02-08T04:59:35ZengElsevierPharmacological Research1096-11862025-02-01212107566New insights into anti-depression effects of bioactive phytochemicalsRuohan Zhao0Jingwen Wang1Sookja Kim Chung2Baojun Xu3Food Science and Technology Program, Department of Life Sciences, BNU-HKBU United International College, Zhuhai, Guangdong 519087, ChinaFood Science and Technology Program, Department of Life Sciences, BNU-HKBU United International College, Zhuhai, Guangdong 519087, ChinaFaculty of Medicine, Macau University of Science and Technology, Macau, China; Corresponding authors.Food Science and Technology Program, Department of Life Sciences, BNU-HKBU United International College, Zhuhai, Guangdong 519087, China; Corresponding authors.Depression is one of the most common psychological disorders, and due to its high prevalence and mortality rates, it imposes a significant disease burden. Contemporary treatments for depression involve various synthetic drugs, which have limitations such as side effects, single targets, and slow onset of action. Unlike synthetic medications, phytochemicals offer the benefits of a multi-target and multi-pathway mode of treatment for depression. In this literature review, we describe the pharmacological actions, experimental models, and clinical trials of the antidepressant effects of various phytochemicals. Additionally, we summarize the potential mechanisms by which these phytochemicals prevent depression, including regulating neurotransmitters and their receptors, the HPA axis, inflammatory responses, managing oxidative stress, neuroplasticity, and the gut microbiome. Phytochemicals exert therapeutic effects through multiple pathways and targets, making traditional Chinese medicine (TCM) a promising adjunctive antidepressant for the prevention, alleviation, and treatment of depression. Therefore, this review aims to provide robust evidence for subsequent research into developing phytochemical resources as effective antidepressant agents.http://www.sciencedirect.com/science/article/pii/S1043661824005115DepressionneurotransmitterHPA axisneuroplasticityneuroinflammationphytochemicals |
| spellingShingle | Ruohan Zhao Jingwen Wang Sookja Kim Chung Baojun Xu New insights into anti-depression effects of bioactive phytochemicals Pharmacological Research Depression neurotransmitter HPA axis neuroplasticity neuroinflammation phytochemicals |
| title | New insights into anti-depression effects of bioactive phytochemicals |
| title_full | New insights into anti-depression effects of bioactive phytochemicals |
| title_fullStr | New insights into anti-depression effects of bioactive phytochemicals |
| title_full_unstemmed | New insights into anti-depression effects of bioactive phytochemicals |
| title_short | New insights into anti-depression effects of bioactive phytochemicals |
| title_sort | new insights into anti depression effects of bioactive phytochemicals |
| topic | Depression neurotransmitter HPA axis neuroplasticity neuroinflammation phytochemicals |
| url | http://www.sciencedirect.com/science/article/pii/S1043661824005115 |
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