Aberration correction in long GRIN lens-based microendoscopes for extended field-of-view two-photon imaging in deep brain regions

Aberration correction in long GRIN lens-based microendoscopes for extended field-of-view two-photon imaging in deep brain regions

Two-photon (2P) fluorescence imaging through gradient index (GRIN) lens-based endoscopes is fundamental to investigate the functional properties of neural populations in deep brain circuits. However, GRIN lenses have intrinsic optical aberrations, which severely degrade their imaging performance. GR...

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Bibliographic Details
Main Authors: Andrea Sattin, Chiara Nardin, Simon Daste, Monica Moroni, Innem Reddy, Carlo Liberale, Stefano Panzeri, Alexander Fleischmann, Tommaso Fellin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-05-01
Series:eLife
Subjects:
gradient index lenses
aberration correction
neural circuits
deep imaging
two-photon imaging
high-resolution
Online Access:https://elifesciences.org/articles/101420
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