Taste triggers a homeostatic temperature control in hungry flies
Hungry animals consistently show a desire to obtain food. Even a brief sensory detection of food can trigger bursts of physiological and behavioral changes. However, the underlying mechanisms by which the sensation of food triggers the acute behavioral response remain elusive. We have previously sho...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2024-12-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/94703 |
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| author | Yujiro Umezaki Sergio Hidalgo Erika Nguyen Tiffany Nguyen Jay Suh Sheena S Uchino Joanna Chiu Fumika Hamada |
| author_facet | Yujiro Umezaki Sergio Hidalgo Erika Nguyen Tiffany Nguyen Jay Suh Sheena S Uchino Joanna Chiu Fumika Hamada |
| author_sort | Yujiro Umezaki |
| collection | DOAJ |
| description | Hungry animals consistently show a desire to obtain food. Even a brief sensory detection of food can trigger bursts of physiological and behavioral changes. However, the underlying mechanisms by which the sensation of food triggers the acute behavioral response remain elusive. We have previously shown in Drosophila that hunger drives a preference for low temperature. Because Drosophila is a small ectotherm, a preference for low temperature implies a low body temperature and a low metabolic rate. Here, we show that taste-sensing triggers a switch from a low to a high temperature preference in hungry flies. We show that taste stimulation by artificial sweeteners or optogenetics triggers an acute warm preference, but is not sufficient to reach the fed state. Instead, nutrient intake is required to reach the fed state. The data suggest that starvation recovery is controlled by two components: taste-evoked and nutrient-induced warm preferences, and that taste and nutrient quality play distinct roles in starvation recovery. Animals are motivated to eat based on time of day or hunger. We found that clock genes and hunger signals profoundly control the taste-evoked warm preferences. Thus, our data suggest that the taste-evoked response is one of the critical layers of regulatory mechanisms representing internal energy homeostasis and metabolism. |
| format | Article |
| id | doaj-art-f57298654fa045a0aba69832f8e73b15 |
| institution | Kabale University |
| issn | 2050-084X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj-art-f57298654fa045a0aba69832f8e73b152024-12-02T14:59:33ZengeLife Sciences Publications LtdeLife2050-084X2024-12-011310.7554/eLife.94703Taste triggers a homeostatic temperature control in hungry fliesYujiro Umezaki0https://orcid.org/0009-0008-1136-8464Sergio Hidalgo1https://orcid.org/0000-0002-2604-156XErika Nguyen2Tiffany Nguyen3Jay Suh4Sheena S Uchino5Joanna Chiu6https://orcid.org/0000-0001-7613-8127Fumika Hamada7https://orcid.org/0009-0003-6537-7386Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, United StatesDepartment of Entomology and Nematology, University of California, Davis, Davis, United StatesDivision of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United StatesDivision of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United StatesDivision of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, United StatesDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, United StatesDepartment of Entomology and Nematology, University of California, Davis, Davis, United StatesDepartment of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, United StatesHungry animals consistently show a desire to obtain food. Even a brief sensory detection of food can trigger bursts of physiological and behavioral changes. However, the underlying mechanisms by which the sensation of food triggers the acute behavioral response remain elusive. We have previously shown in Drosophila that hunger drives a preference for low temperature. Because Drosophila is a small ectotherm, a preference for low temperature implies a low body temperature and a low metabolic rate. Here, we show that taste-sensing triggers a switch from a low to a high temperature preference in hungry flies. We show that taste stimulation by artificial sweeteners or optogenetics triggers an acute warm preference, but is not sufficient to reach the fed state. Instead, nutrient intake is required to reach the fed state. The data suggest that starvation recovery is controlled by two components: taste-evoked and nutrient-induced warm preferences, and that taste and nutrient quality play distinct roles in starvation recovery. Animals are motivated to eat based on time of day or hunger. We found that clock genes and hunger signals profoundly control the taste-evoked warm preferences. Thus, our data suggest that the taste-evoked response is one of the critical layers of regulatory mechanisms representing internal energy homeostasis and metabolism.https://elifesciences.org/articles/94703gustatory receptorstemperature-sensing neuronscircadian clockbody temperaturestarvationcephalic phase response |
| spellingShingle | Yujiro Umezaki Sergio Hidalgo Erika Nguyen Tiffany Nguyen Jay Suh Sheena S Uchino Joanna Chiu Fumika Hamada Taste triggers a homeostatic temperature control in hungry flies eLife gustatory receptors temperature-sensing neurons circadian clock body temperature starvation cephalic phase response |
| title | Taste triggers a homeostatic temperature control in hungry flies |
| title_full | Taste triggers a homeostatic temperature control in hungry flies |
| title_fullStr | Taste triggers a homeostatic temperature control in hungry flies |
| title_full_unstemmed | Taste triggers a homeostatic temperature control in hungry flies |
| title_short | Taste triggers a homeostatic temperature control in hungry flies |
| title_sort | taste triggers a homeostatic temperature control in hungry flies |
| topic | gustatory receptors temperature-sensing neurons circadian clock body temperature starvation cephalic phase response |
| url | https://elifesciences.org/articles/94703 |
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