Saponins and their role as vaccine adjuvant against coccidiosis in poultry
Coccidiosis, induced by various Eimeria species, has been one of the most important health threats and performance of poultry around the world. Other than the current treatment, successful vaccination approaches have been realized. Advances in saponin biochemistry, from Quillaja saponaria and Yucca...
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| Format: | Article |
| Language: | English |
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Kafkas University, Faculty of Veterinary Medicine
2025-06-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
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| Online Access: | https://vetdergikafkas.org/pdf.php?id=3198 |
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| author | Abdullah F. ALSAYEQH |
| author_facet | Abdullah F. ALSAYEQH |
| author_sort | Abdullah F. ALSAYEQH |
| collection | DOAJ |
| description | Coccidiosis, induced by various Eimeria species, has been one of the most important
health threats and performance of poultry around the world. Other than the current
treatment, successful vaccination approaches have been realized. Advances in saponin
biochemistry, from Quillaja saponaria and Yucca schidigera plants, have supported the
development of vaccine adjuvants based on these natural glycosides. Saponins also
activate innate immune pathways and can assist with antigen presentation, enhancing
humoral and cell-mediated responses. Saponin-based adjuvants, including QS-21
and Quil A, can enhance adjuvant efficacy by inducing higher antibody responses
and promoting long-lasting protective immunity privation. Nonetheless, challenges
including toxicity issues about the saponin fractions and the variable adjuvant activity
among different saponins, have also been reported. Future studies aim to improve
saponin adjuvant formulations, determine their harmlessness, and investigate new
transport systems, such as immunostimulating complexes. By enhancing poultry health,
such advancements contribute to safer meat and egg products, directly supporting
food safety. Moreover, reducing disease-related losses in poultry farms promotes food
security by ensuring stable and efficient protein production. The focus of this review
article is to highlight the role of saponins as vaccine adjuvants to enhance immunity
against Eimeria species in poultry. |
| format | Article |
| id | doaj-art-f5707f201b684f2f9abe4f708d90190e |
| institution | Kabale University |
| issn | 1309-2251 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj-art-f5707f201b684f2f9abe4f708d90190e2025-08-20T03:26:34ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1309-22512025-06-0131335135910.9775/kvfd.2025.341963198Saponins and their role as vaccine adjuvant against coccidiosis in poultryAbdullah F. ALSAYEQH0Department of Veterinary Preventive Medicine, College of Veterinary Medicine, Qassim University, Buriadah, SAUDI ARABIACoccidiosis, induced by various Eimeria species, has been one of the most important health threats and performance of poultry around the world. Other than the current treatment, successful vaccination approaches have been realized. Advances in saponin biochemistry, from Quillaja saponaria and Yucca schidigera plants, have supported the development of vaccine adjuvants based on these natural glycosides. Saponins also activate innate immune pathways and can assist with antigen presentation, enhancing humoral and cell-mediated responses. Saponin-based adjuvants, including QS-21 and Quil A, can enhance adjuvant efficacy by inducing higher antibody responses and promoting long-lasting protective immunity privation. Nonetheless, challenges including toxicity issues about the saponin fractions and the variable adjuvant activity among different saponins, have also been reported. Future studies aim to improve saponin adjuvant formulations, determine their harmlessness, and investigate new transport systems, such as immunostimulating complexes. By enhancing poultry health, such advancements contribute to safer meat and egg products, directly supporting food safety. Moreover, reducing disease-related losses in poultry farms promotes food security by ensuring stable and efficient protein production. The focus of this review article is to highlight the role of saponins as vaccine adjuvants to enhance immunity against Eimeria species in poultry.https://vetdergikafkas.org/pdf.php?id=3198coccidiosiseimeriafood safetyphytochemicalsquil asaponinsvaccine adjuvants |
| spellingShingle | Abdullah F. ALSAYEQH Saponins and their role as vaccine adjuvant against coccidiosis in poultry Kafkas Universitesi Veteriner Fakültesi Dergisi coccidiosis eimeria food safety phytochemicals quil a saponins vaccine adjuvants |
| title | Saponins and their role as vaccine adjuvant against coccidiosis in poultry |
| title_full | Saponins and their role as vaccine adjuvant against coccidiosis in poultry |
| title_fullStr | Saponins and their role as vaccine adjuvant against coccidiosis in poultry |
| title_full_unstemmed | Saponins and their role as vaccine adjuvant against coccidiosis in poultry |
| title_short | Saponins and their role as vaccine adjuvant against coccidiosis in poultry |
| title_sort | saponins and their role as vaccine adjuvant against coccidiosis in poultry |
| topic | coccidiosis eimeria food safety phytochemicals quil a saponins vaccine adjuvants |
| url | https://vetdergikafkas.org/pdf.php?id=3198 |
| work_keys_str_mv | AT abdullahfalsayeqh saponinsandtheirroleasvaccineadjuvantagainstcoccidiosisinpoultry |