BMI1 regulates human erythroid self-renewal through both gene repression and gene activation

BMI1 regulates human erythroid self-renewal through both gene repression and gene activation

Abstract The limited proliferative capacity of erythroid precursors is a major obstacle to generate sufficient in vitro-derived red blood cells for clinical purposes. While BMI1, a Polycomb Repressive Complex 1 member, is both necessary and sufficient to drive extensive proliferation of self-renewin...

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Main Authors: Kathleen E. McGrath, Jayme L. Olsen, Anne D. Koniski, Kristin E. Murphy, Michael Getman, Hyun Hyung An, Vincent P. Schulz, Ah Ram Kim, Bin Zhang, Taylor L. Carlson, Julien Papoin, Lionel Blanc, Paul D. Kingsley, Connie M. Westhoff, Patrick G. Gallagher, Stella T. Chou, Laurie A. Steiner, James Palis
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62993-3
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