Retinal Ganglion Cell Atrophy in Homonymous Hemianopia due to Acquired Occipital Lesions Observed Using Cirrus High-Definition-OCT
Purpose. To report a reduction in macular ganglion cell layer and inner plexiform layer (GCL+IPL) thickness and circumpapillary retinal nerve fiber layer (cpRNFL) thickness using spectral-domain optical coherence tomography in patients with homonymous hemianopia due to posterior cerebral artery (PCA...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/2394957 |
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| author | Tsutomu Yamashita Atsushi Miki Katsutoshi Goto Syunsuke Araki Go Takizawa Yoshiaki Ieki Junichi Kiryu Akio Tabuchi Yasuyuki Iguchi Kazumi Kimura Yoshiki Yagita |
| author_facet | Tsutomu Yamashita Atsushi Miki Katsutoshi Goto Syunsuke Araki Go Takizawa Yoshiaki Ieki Junichi Kiryu Akio Tabuchi Yasuyuki Iguchi Kazumi Kimura Yoshiki Yagita |
| author_sort | Tsutomu Yamashita |
| collection | DOAJ |
| description | Purpose. To report a reduction in macular ganglion cell layer and inner plexiform layer (GCL+IPL) thickness and circumpapillary retinal nerve fiber layer (cpRNFL) thickness using spectral-domain optical coherence tomography in patients with homonymous hemianopia due to posterior cerebral artery (PCA) stroke. Methods. Seven patients with PCA stroke were examined using Cirrus high-definition-OCT. The GCL+IPL thicknesses were divided into the hemianopic and unaffected sides. The relationship between the time after stroke and the GCL+IPL thicknesses in the hemianopic side was evaluated. Results. The average thicknesses of the GCL+IPL were 64.6 and 82.0 μm on the hemianopic and unaffected sides, respectively, and the measurement was significantly thinner on the former side (p=0.018). A regression analysis revealed a negative linear relationship (R2=0.574, p=0.049) between the time after stoke and the GCL+IPL thicknesses on the hemianopic side. The supratemporal and inferotemporal cpRNFL thicknesses in the eyes ipsilateral to the stroke showed a significant reduction. Conclusion. Our findings confirmed our previous observations that the degeneration of retinal ganglion cells can occur after PCA stroke. GCL+IPL thinning was demonstrated in the hemiretinae corresponding to the affected hemifields. Also, it is suggested that the retinal changes observed are progressive. |
| format | Article |
| id | doaj-art-f567654953f1492abe6595f2884d1068 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-f567654953f1492abe6595f2884d10682025-02-03T01:02:31ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/23949572394957Retinal Ganglion Cell Atrophy in Homonymous Hemianopia due to Acquired Occipital Lesions Observed Using Cirrus High-Definition-OCTTsutomu Yamashita0Atsushi Miki1Katsutoshi Goto2Syunsuke Araki3Go Takizawa4Yoshiaki Ieki5Junichi Kiryu6Akio Tabuchi7Yasuyuki Iguchi8Kazumi Kimura9Yoshiki Yagita10Department of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193, JapanDepartment of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193, JapanDepartment of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, JapanDepartment of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, JapanDepartment of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, JapanDepartment of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, JapanDepartment of Ophthalmology, Kawasaki Medical School, Kurashiki, Okayama 701-0192, JapanDepartment of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Okayama 701-0193, JapanDepartment of Neurology, The Jikei University School of Medicine, Minato-ku, Tokyo 105-8471, JapanDepartment of Neurological Science, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo 113-8603, JapanDepartment of Stroke Medicine, Kawasaki Medical School, Kurashiki, Okayama 701-0192, JapanPurpose. To report a reduction in macular ganglion cell layer and inner plexiform layer (GCL+IPL) thickness and circumpapillary retinal nerve fiber layer (cpRNFL) thickness using spectral-domain optical coherence tomography in patients with homonymous hemianopia due to posterior cerebral artery (PCA) stroke. Methods. Seven patients with PCA stroke were examined using Cirrus high-definition-OCT. The GCL+IPL thicknesses were divided into the hemianopic and unaffected sides. The relationship between the time after stroke and the GCL+IPL thicknesses in the hemianopic side was evaluated. Results. The average thicknesses of the GCL+IPL were 64.6 and 82.0 μm on the hemianopic and unaffected sides, respectively, and the measurement was significantly thinner on the former side (p=0.018). A regression analysis revealed a negative linear relationship (R2=0.574, p=0.049) between the time after stoke and the GCL+IPL thicknesses on the hemianopic side. The supratemporal and inferotemporal cpRNFL thicknesses in the eyes ipsilateral to the stroke showed a significant reduction. Conclusion. Our findings confirmed our previous observations that the degeneration of retinal ganglion cells can occur after PCA stroke. GCL+IPL thinning was demonstrated in the hemiretinae corresponding to the affected hemifields. Also, it is suggested that the retinal changes observed are progressive.http://dx.doi.org/10.1155/2016/2394957 |
| spellingShingle | Tsutomu Yamashita Atsushi Miki Katsutoshi Goto Syunsuke Araki Go Takizawa Yoshiaki Ieki Junichi Kiryu Akio Tabuchi Yasuyuki Iguchi Kazumi Kimura Yoshiki Yagita Retinal Ganglion Cell Atrophy in Homonymous Hemianopia due to Acquired Occipital Lesions Observed Using Cirrus High-Definition-OCT Journal of Ophthalmology |
| title | Retinal Ganglion Cell Atrophy in Homonymous Hemianopia due to Acquired Occipital Lesions Observed Using Cirrus High-Definition-OCT |
| title_full | Retinal Ganglion Cell Atrophy in Homonymous Hemianopia due to Acquired Occipital Lesions Observed Using Cirrus High-Definition-OCT |
| title_fullStr | Retinal Ganglion Cell Atrophy in Homonymous Hemianopia due to Acquired Occipital Lesions Observed Using Cirrus High-Definition-OCT |
| title_full_unstemmed | Retinal Ganglion Cell Atrophy in Homonymous Hemianopia due to Acquired Occipital Lesions Observed Using Cirrus High-Definition-OCT |
| title_short | Retinal Ganglion Cell Atrophy in Homonymous Hemianopia due to Acquired Occipital Lesions Observed Using Cirrus High-Definition-OCT |
| title_sort | retinal ganglion cell atrophy in homonymous hemianopia due to acquired occipital lesions observed using cirrus high definition oct |
| url | http://dx.doi.org/10.1155/2016/2394957 |
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