Iron-Catalyzed Cross-Dehydrogenative Coupling
This review highlights significant advances in iron-catalyzed cross-dehydrogenative coupling (CDC), a method pivotal for forming carbon-carbon (C-C) bonds directly from C-H bonds. This technique uses iron—a naturally abundant, inexpensive, and environmentally benign transition metal—as a catalyst to...
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MDPI AG
2025-01-01
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| author | Haiyan Diao Yujia Chen Feng Liu |
| author_facet | Haiyan Diao Yujia Chen Feng Liu |
| author_sort | Haiyan Diao |
| collection | DOAJ |
| description | This review highlights significant advances in iron-catalyzed cross-dehydrogenative coupling (CDC), a method pivotal for forming carbon-carbon (C-C) bonds directly from C-H bonds. This technique uses iron—a naturally abundant, inexpensive, and environmentally benign transition metal—as a catalyst to facilitate the coupling of two unfunctionalized C-H bonds. This method stands out for avoiding pre-functionalized substrates, reducing both waste and cost in organic synthesis. The discussion includes a variety of CDC methodologies involving combinations of C(sp<sup>3</sup>)-H with C(sp<sup>3</sup>)-H, C(sp<sup>3</sup>)-H with C(sp<sup>2</sup>)-H, and C(sp<sup>3</sup>)-H with C(sp)-H bonds. These methods have been successfully applied in synthesizing complex molecules and pharmaceuticals, highlighting the versatility and efficiency of iron catalysis. |
| format | Article |
| id | doaj-art-f564eea077194a0a8c7b5cdc9a9decf0 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-f564eea077194a0a8c7b5cdc9a9decf02025-01-24T13:43:15ZengMDPI AGMolecules1420-30492025-01-0130225010.3390/molecules30020250Iron-Catalyzed Cross-Dehydrogenative CouplingHaiyan Diao0Yujia Chen1Feng Liu2Department of Chemistry, Fudan University, Shanghai 200438, ChinaSchool of Chemistry and Chemical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, ChinaDepartment of Chemistry, Fudan University, Shanghai 200438, ChinaThis review highlights significant advances in iron-catalyzed cross-dehydrogenative coupling (CDC), a method pivotal for forming carbon-carbon (C-C) bonds directly from C-H bonds. This technique uses iron—a naturally abundant, inexpensive, and environmentally benign transition metal—as a catalyst to facilitate the coupling of two unfunctionalized C-H bonds. This method stands out for avoiding pre-functionalized substrates, reducing both waste and cost in organic synthesis. The discussion includes a variety of CDC methodologies involving combinations of C(sp<sup>3</sup>)-H with C(sp<sup>3</sup>)-H, C(sp<sup>3</sup>)-H with C(sp<sup>2</sup>)-H, and C(sp<sup>3</sup>)-H with C(sp)-H bonds. These methods have been successfully applied in synthesizing complex molecules and pharmaceuticals, highlighting the versatility and efficiency of iron catalysis.https://www.mdpi.com/1420-3049/30/2/250iron catalysiscross-dehydrogenative couplingC-H bond activationgreen synthesisorganic transformations |
| spellingShingle | Haiyan Diao Yujia Chen Feng Liu Iron-Catalyzed Cross-Dehydrogenative Coupling Molecules iron catalysis cross-dehydrogenative coupling C-H bond activation green synthesis organic transformations |
| title | Iron-Catalyzed Cross-Dehydrogenative Coupling |
| title_full | Iron-Catalyzed Cross-Dehydrogenative Coupling |
| title_fullStr | Iron-Catalyzed Cross-Dehydrogenative Coupling |
| title_full_unstemmed | Iron-Catalyzed Cross-Dehydrogenative Coupling |
| title_short | Iron-Catalyzed Cross-Dehydrogenative Coupling |
| title_sort | iron catalyzed cross dehydrogenative coupling |
| topic | iron catalysis cross-dehydrogenative coupling C-H bond activation green synthesis organic transformations |
| url | https://www.mdpi.com/1420-3049/30/2/250 |
| work_keys_str_mv | AT haiyandiao ironcatalyzedcrossdehydrogenativecoupling AT yujiachen ironcatalyzedcrossdehydrogenativecoupling AT fengliu ironcatalyzedcrossdehydrogenativecoupling |