Iron-Catalyzed Cross-Dehydrogenative Coupling

Iron-Catalyzed Cross-Dehydrogenative Coupling

This review highlights significant advances in iron-catalyzed cross-dehydrogenative coupling (CDC), a method pivotal for forming carbon-carbon (C-C) bonds directly from C-H bonds. This technique uses iron—a naturally abundant, inexpensive, and environmentally benign transition metal—as a catalyst to...

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Bibliographic Details
Main Authors: Haiyan Diao, Yujia Chen, Feng Liu
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
iron catalysis
cross-dehydrogenative coupling
C-H bond activation
green synthesis
organic transformations
Online Access:https://www.mdpi.com/1420-3049/30/2/250
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Summary:This review highlights significant advances in iron-catalyzed cross-dehydrogenative coupling (CDC), a method pivotal for forming carbon-carbon (C-C) bonds directly from C-H bonds. This technique uses iron—a naturally abundant, inexpensive, and environmentally benign transition metal—as a catalyst to facilitate the coupling of two unfunctionalized C-H bonds. This method stands out for avoiding pre-functionalized substrates, reducing both waste and cost in organic synthesis. The discussion includes a variety of CDC methodologies involving combinations of C(sp<sup>3</sup>)-H with C(sp<sup>3</sup>)-H, C(sp<sup>3</sup>)-H with C(sp<sup>2</sup>)-H, and C(sp<sup>3</sup>)-H with C(sp)-H bonds. These methods have been successfully applied in synthesizing complex molecules and pharmaceuticals, highlighting the versatility and efficiency of iron catalysis.
ISSN:1420-3049

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