The impact of cranberry on lower urinary tract function: limitations due to gene expression and pharmacokinetic variability
Cranberries are well known for their antioxidative, anti-inflammatory, antimicrobial, and anti-biofilm formation properties. Many studies indicate their potential for cancer prevention, blood sugar regulation, gastrointestinal and cardiovascular health, and antiviral properties. Such wide therapeuti...
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| Format: | Article |
| Language: | Bulgarian |
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University of Zagreb, Faculty of Agriculture
2025-06-01
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| Series: | Journal of Central European Agriculture |
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| Online Access: | https://jcea.agr.hr/articles/771308_The_impact_of_cranberry_on_lower_urinary_tract_function_limitations_due_to_gene_expression_and_pharmacokinetic_variability_en.pdf |
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| _version_ | 1849431081600679936 |
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| author | Anisa VELEDAR-HAMALUKIĆ |
| author_facet | Anisa VELEDAR-HAMALUKIĆ |
| author_sort | Anisa VELEDAR-HAMALUKIĆ |
| collection | DOAJ |
| description | Cranberries are well known for their antioxidative, anti-inflammatory, antimicrobial, and anti-biofilm formation properties. Many studies indicate their potential for cancer prevention, blood sugar regulation, gastrointestinal and cardiovascular health, and antiviral properties. Such wide therapeutic potential for human health has made cranberries favourable for dietary formulations. Considering how prone patients are to accept treatment via nature's pharmacy instead of the conventional one, cranberries in the form of juice, tablets, capsules, or extracts are often prescribed alongside antibiotic therapy for urinary tract infection (UTI) treatment. This review paper aims to provide a better understanding of the limitations of the usage of berry dietary formulations for health improvement. The healing potential of cranberries is limited due to the bioaccessibility of their ingredients and their pharmacokinetic properties. Although rich with pharmacologically active substances, including anthocyanins, proanthocyanidins, vitamin C, vitamins (B1, B2, B3, B5, B6, B9), and organic acids, their potential is limited due to low absorption and distribution, extensive metabolism, and elimination. The variability in gene expression affecting the biosynthesis of anthocyanins and proanthocyanidins within the Vaccinium berries results in diminished concentrations of active ingredients within the plant material itself. Also, the results from the clinical trials are inconsistently standardized. This paper offers a comprehensive analysis of the available data and presents a clear direction for future research. |
| format | Article |
| id | doaj-art-f562f5ecdb5e46a2a7bf22072776fe7e |
| institution | Kabale University |
| issn | 1332-9049 |
| language | Bulgarian |
| publishDate | 2025-06-01 |
| publisher | University of Zagreb, Faculty of Agriculture |
| record_format | Article |
| series | Journal of Central European Agriculture |
| spelling | doaj-art-f562f5ecdb5e46a2a7bf22072776fe7e2025-08-20T03:27:46ZbulUniversity of Zagreb, Faculty of AgricultureJournal of Central European Agriculture1332-90492025-06-0126243745510.5513/JCEA01/26.2.4499The impact of cranberry on lower urinary tract function: limitations due to gene expression and pharmacokinetic variabilityAnisa VELEDAR-HAMALUKIĆCranberries are well known for their antioxidative, anti-inflammatory, antimicrobial, and anti-biofilm formation properties. Many studies indicate their potential for cancer prevention, blood sugar regulation, gastrointestinal and cardiovascular health, and antiviral properties. Such wide therapeutic potential for human health has made cranberries favourable for dietary formulations. Considering how prone patients are to accept treatment via nature's pharmacy instead of the conventional one, cranberries in the form of juice, tablets, capsules, or extracts are often prescribed alongside antibiotic therapy for urinary tract infection (UTI) treatment. This review paper aims to provide a better understanding of the limitations of the usage of berry dietary formulations for health improvement. The healing potential of cranberries is limited due to the bioaccessibility of their ingredients and their pharmacokinetic properties. Although rich with pharmacologically active substances, including anthocyanins, proanthocyanidins, vitamin C, vitamins (B1, B2, B3, B5, B6, B9), and organic acids, their potential is limited due to low absorption and distribution, extensive metabolism, and elimination. The variability in gene expression affecting the biosynthesis of anthocyanins and proanthocyanidins within the Vaccinium berries results in diminished concentrations of active ingredients within the plant material itself. Also, the results from the clinical trials are inconsistently standardized. This paper offers a comprehensive analysis of the available data and presents a clear direction for future research.https://jcea.agr.hr/articles/771308_The_impact_of_cranberry_on_lower_urinary_tract_function_limitations_due_to_gene_expression_and_pharmacokinetic_variability_en.pdfproanthocyanidinanthocyaninscranberryvaccinium spurinary tract infectionescherichia coli |
| spellingShingle | Anisa VELEDAR-HAMALUKIĆ The impact of cranberry on lower urinary tract function: limitations due to gene expression and pharmacokinetic variability Journal of Central European Agriculture proanthocyanidin anthocyanins cranberry vaccinium sp urinary tract infection escherichia coli |
| title | The impact of cranberry on lower urinary tract function: limitations due to gene expression and pharmacokinetic variability |
| title_full | The impact of cranberry on lower urinary tract function: limitations due to gene expression and pharmacokinetic variability |
| title_fullStr | The impact of cranberry on lower urinary tract function: limitations due to gene expression and pharmacokinetic variability |
| title_full_unstemmed | The impact of cranberry on lower urinary tract function: limitations due to gene expression and pharmacokinetic variability |
| title_short | The impact of cranberry on lower urinary tract function: limitations due to gene expression and pharmacokinetic variability |
| title_sort | impact of cranberry on lower urinary tract function limitations due to gene expression and pharmacokinetic variability |
| topic | proanthocyanidin anthocyanins cranberry vaccinium sp urinary tract infection escherichia coli |
| url | https://jcea.agr.hr/articles/771308_The_impact_of_cranberry_on_lower_urinary_tract_function_limitations_due_to_gene_expression_and_pharmacokinetic_variability_en.pdf |
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