Two previously undescribed triterpenoid saponins from the roots and rhizomes of Caulophyllum robustum Maxim
Since ancient times, plants have provided humans with important bioactive compounds for the treatment of various diseases. Nine compounds were isolated from the roots and rhizomes of Caulophyllum robustum (a plant in the family Panaxaceae), including two new saponins C. Spanion A and C. Spanion B (1...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2024.1507891/full |
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| author | Cong-Yu Zhang Yu-Mei Wang Peng-Cheng Qiu Jia-Yu Feng Bing-Wen Wang Yu Cao Yi-Sha Wei Yi-Tong Zhou Hai-Feng Tang Yun-Yang Lu Qian Zhang |
| author_facet | Cong-Yu Zhang Yu-Mei Wang Peng-Cheng Qiu Jia-Yu Feng Bing-Wen Wang Yu Cao Yi-Sha Wei Yi-Tong Zhou Hai-Feng Tang Yun-Yang Lu Qian Zhang |
| author_sort | Cong-Yu Zhang |
| collection | DOAJ |
| description | Since ancient times, plants have provided humans with important bioactive compounds for the treatment of various diseases. Nine compounds were isolated from the roots and rhizomes of Caulophyllum robustum (a plant in the family Panaxaceae), including two new saponins C. Spanion A and C. Spanion B (1-2) and seven known saponins (3-9). The cytotoxicity of these compounds on human cancer cell lines was analyzed using MTT method. Compounds 6 and 9 exhibit cytotoxicity towards these three types of human cancer cells (<10 μM). By utilizing the SEA platform for target prediction, a common tumor related target CD81 was identified. The molecular docking of saponins 1, 2, 6, and 9 with CD81 protein showed strong binding affinities ranging from -4.5 to -7.1 kcal/mol. Research has shown that these compounds can become potential anti-tumor drugs. Further research is still recommended to understand its exact molecular mechanism and toxicological effects. |
| format | Article |
| id | doaj-art-f561798872944a4f8e88b6d1fb6d13d6 |
| institution | Kabale University |
| issn | 2296-2646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj-art-f561798872944a4f8e88b6d1fb6d13d62025-01-09T06:10:41ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462025-01-011210.3389/fchem.2024.15078911507891Two previously undescribed triterpenoid saponins from the roots and rhizomes of Caulophyllum robustum MaximCong-Yu Zhang0Yu-Mei Wang1Peng-Cheng Qiu2Jia-Yu Feng3Bing-Wen Wang4Yu Cao5Yi-Sha Wei6Yi-Tong Zhou7Hai-Feng Tang8Yun-Yang Lu9Qian Zhang10Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, The Air Force Medical University, Xi’an, ChinaSchool of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, ChinaDepartment of Chinese Materia Medica and Natural Medicines, School of Pharmacy, The Air Force Medical University, Xi’an, ChinaSchool of Public Health, Health Science Center, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Chinese Materia Medica and Natural Medicines, School of Pharmacy, The Air Force Medical University, Xi’an, ChinaDepartment of Chinese Materia Medica and Natural Medicines, School of Pharmacy, The Air Force Medical University, Xi’an, ChinaSchool of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, ChinaSchool of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, ChinaDepartment of Chinese Materia Medica and Natural Medicines, School of Pharmacy, The Air Force Medical University, Xi’an, ChinaDepartment of Chinese Materia Medica and Natural Medicines, School of Pharmacy, The Air Force Medical University, Xi’an, ChinaDepartment of Chinese Materia Medica and Natural Medicines, School of Pharmacy, The Air Force Medical University, Xi’an, ChinaSince ancient times, plants have provided humans with important bioactive compounds for the treatment of various diseases. Nine compounds were isolated from the roots and rhizomes of Caulophyllum robustum (a plant in the family Panaxaceae), including two new saponins C. Spanion A and C. Spanion B (1-2) and seven known saponins (3-9). The cytotoxicity of these compounds on human cancer cell lines was analyzed using MTT method. Compounds 6 and 9 exhibit cytotoxicity towards these three types of human cancer cells (<10 μM). By utilizing the SEA platform for target prediction, a common tumor related target CD81 was identified. The molecular docking of saponins 1, 2, 6, and 9 with CD81 protein showed strong binding affinities ranging from -4.5 to -7.1 kcal/mol. Research has shown that these compounds can become potential anti-tumor drugs. Further research is still recommended to understand its exact molecular mechanism and toxicological effects.https://www.frontiersin.org/articles/10.3389/fchem.2024.1507891/fullCaulophyllum robustum MaximTriterpenoid saponinstructure identificationantitumor activitymolecular docking |
| spellingShingle | Cong-Yu Zhang Yu-Mei Wang Peng-Cheng Qiu Jia-Yu Feng Bing-Wen Wang Yu Cao Yi-Sha Wei Yi-Tong Zhou Hai-Feng Tang Yun-Yang Lu Qian Zhang Two previously undescribed triterpenoid saponins from the roots and rhizomes of Caulophyllum robustum Maxim Frontiers in Chemistry Caulophyllum robustum Maxim Triterpenoid saponin structure identification antitumor activity molecular docking |
| title | Two previously undescribed triterpenoid saponins from the roots and rhizomes of Caulophyllum robustum Maxim |
| title_full | Two previously undescribed triterpenoid saponins from the roots and rhizomes of Caulophyllum robustum Maxim |
| title_fullStr | Two previously undescribed triterpenoid saponins from the roots and rhizomes of Caulophyllum robustum Maxim |
| title_full_unstemmed | Two previously undescribed triterpenoid saponins from the roots and rhizomes of Caulophyllum robustum Maxim |
| title_short | Two previously undescribed triterpenoid saponins from the roots and rhizomes of Caulophyllum robustum Maxim |
| title_sort | two previously undescribed triterpenoid saponins from the roots and rhizomes of caulophyllum robustum maxim |
| topic | Caulophyllum robustum Maxim Triterpenoid saponin structure identification antitumor activity molecular docking |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2024.1507891/full |
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