Chemokines: humble yet mighty players in the tumour microenvironment
Chemokines are tiny chemotactic cytokines which play a crucial role in pathophysiology by maintaining homeostasis and inflammation. Their role in the tumour microenvironment is very much puzzling because of both pro- and anti-tumourigenic effects. Chemokines have gained much attention today, since i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1601756/full |
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| author | Hima Xavier Hima Xavier Athira Gireesh Moly Gireesh Juvin Ann Thomas Priya Suboj Priya Suboj Arya Suresh Arya Suresh Emmanuel Biju Arya Baby Roshin Thomas Dominic Suboj Babykutty Suboj Babykutty |
| author_facet | Hima Xavier Hima Xavier Athira Gireesh Moly Gireesh Juvin Ann Thomas Priya Suboj Priya Suboj Arya Suresh Arya Suresh Emmanuel Biju Arya Baby Roshin Thomas Dominic Suboj Babykutty Suboj Babykutty |
| author_sort | Hima Xavier |
| collection | DOAJ |
| description | Chemokines are tiny chemotactic cytokines which play a crucial role in pathophysiology by maintaining homeostasis and inflammation. Their role in the tumour microenvironment is very much puzzling because of both pro- and anti-tumourigenic effects. Chemokines have gained much attention today, since it has been recognized that they are game changers in the TME via controlling immune cell recruitment, angiogenesis, metastasis, tumour growth and drug resistance. In this review, we are exploring the role of several chemokines and their receptors in the TME with special focus on immune cell recruitment, immune surveillance, regulation of immune checkpoints and epithelial mesenchymal transition. We are also reviewing the possibility of targeting chemokines along with immunotherapy for better outcome and disease-free survival. A better understanding on the dual role of chemokine in the TME might help to implement novel therapeutic interventions and adopt precision in targeted therapy. |
| format | Article |
| id | doaj-art-f5378cf3d63b417fa0d85582a804f65c |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-f5378cf3d63b417fa0d85582a804f65c2025-08-20T03:41:00ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-08-011610.3389/fimmu.2025.16017561601756Chemokines: humble yet mighty players in the tumour microenvironmentHima Xavier0Hima Xavier1Athira Gireesh Moly Gireesh2Juvin Ann Thomas3Priya Suboj4Priya Suboj5Arya Suresh6Arya Suresh7Emmanuel Biju8Arya Baby9Roshin Thomas Dominic10Suboj Babykutty11Suboj Babykutty12Centre for Tumour Immunology and Microenvironment, Department of Zoology, Mar Ivanios College, Thiruvananthapuram, Kerala, IndiaDepartment of Biotechnology, CEPCI Laboratory and Research Institute, Kollam, IndiaCentre for Tumour Immunology and Microenvironment, Department of Zoology, Mar Ivanios College, Thiruvananthapuram, Kerala, IndiaCentre for Tumour Immunology and Microenvironment, Department of Zoology, Mar Ivanios College, Thiruvananthapuram, Kerala, IndiaDepartment of Biotechnology, CEPCI Laboratory and Research Institute, Kollam, IndiaDepartment of Botany and Biotechnology, St. Xaviers College, Thiruvananthapuram, Kerala, IndiaCentre for Tumour Immunology and Microenvironment, Department of Zoology, Mar Ivanios College, Thiruvananthapuram, Kerala, IndiaDepartment of Biotechnology, CEPCI Laboratory and Research Institute, Kollam, IndiaCentre for Tumour Immunology and Microenvironment, Department of Zoology, Mar Ivanios College, Thiruvananthapuram, Kerala, IndiaCentre for Tumour Immunology and Microenvironment, Department of Zoology, Mar Ivanios College, Thiruvananthapuram, Kerala, IndiaCentre for Tumour Immunology and Microenvironment, Department of Zoology, Mar Ivanios College, Thiruvananthapuram, Kerala, IndiaCentre for Tumour Immunology and Microenvironment, Department of Zoology, Mar Ivanios College, Thiruvananthapuram, Kerala, IndiaDepartment of Biotechnology, CEPCI Laboratory and Research Institute, Kollam, IndiaChemokines are tiny chemotactic cytokines which play a crucial role in pathophysiology by maintaining homeostasis and inflammation. Their role in the tumour microenvironment is very much puzzling because of both pro- and anti-tumourigenic effects. Chemokines have gained much attention today, since it has been recognized that they are game changers in the TME via controlling immune cell recruitment, angiogenesis, metastasis, tumour growth and drug resistance. In this review, we are exploring the role of several chemokines and their receptors in the TME with special focus on immune cell recruitment, immune surveillance, regulation of immune checkpoints and epithelial mesenchymal transition. We are also reviewing the possibility of targeting chemokines along with immunotherapy for better outcome and disease-free survival. A better understanding on the dual role of chemokine in the TME might help to implement novel therapeutic interventions and adopt precision in targeted therapy.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1601756/fulltumour microenvironmentchemokinesimmune surveillanceimmunotherapyangiogenesis |
| spellingShingle | Hima Xavier Hima Xavier Athira Gireesh Moly Gireesh Juvin Ann Thomas Priya Suboj Priya Suboj Arya Suresh Arya Suresh Emmanuel Biju Arya Baby Roshin Thomas Dominic Suboj Babykutty Suboj Babykutty Chemokines: humble yet mighty players in the tumour microenvironment Frontiers in Immunology tumour microenvironment chemokines immune surveillance immunotherapy angiogenesis |
| title | Chemokines: humble yet mighty players in the tumour microenvironment |
| title_full | Chemokines: humble yet mighty players in the tumour microenvironment |
| title_fullStr | Chemokines: humble yet mighty players in the tumour microenvironment |
| title_full_unstemmed | Chemokines: humble yet mighty players in the tumour microenvironment |
| title_short | Chemokines: humble yet mighty players in the tumour microenvironment |
| title_sort | chemokines humble yet mighty players in the tumour microenvironment |
| topic | tumour microenvironment chemokines immune surveillance immunotherapy angiogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1601756/full |
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