Genotoxic Effects of Etoposide, Bleomycin, and Ethyl Methanesulfonate on Cultured CHO Cells: Analysis by GC-MS/MS and Comet Assay

Genotoxic Effects of Etoposide, Bleomycin, and Ethyl Methanesulfonate on Cultured CHO Cells: Analysis by GC-MS/MS and Comet Assay

To evaluate methods for analysis of genotoxic effects on mammalian cell lines, we tested the effect of three common genotoxic agents on Chinese hamster ovary (CHO) cells by single-cell gel electrophoresis (comet assay) and gas chromatography-tandem mass spectrometry (GC-MS/MS). Suspension-grown CHO...

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Bibliographic Details
Main Authors:	Donald H. Atha, Erdem Coskun, Onur Erdem, Alessandro Tona, Vytas Reipa, Bryant C. Nelson
Format:	Article
Language:	English
Published:	Wiley 2020-01-01
Series:	Journal of Nucleic Acids
Online Access:	http://dx.doi.org/10.1155/2020/8810105
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