Pectin-carbonate hydroxyapatite composite films as a potential drug delivery system for cinnamaldehyde: Characterization and release kinetics modeling
Pectin-based films incorporating carbonate hydroxyapatite (CHA) as a cinnamaldehyde carrier present a novel approach to oral drug delivery, addressing the limitations of pectin's hydrophilicity while leveraging CHA's porosity and adsorption capabilities to enhance controlled release proper...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Case Studies in Chemical and Environmental Engineering |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666016424002998 |
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| author | Nisaul Fadilah Dalimunthe Sang Kompiang Wirawan Michael Michael Thiodorus Marvin Tjandra Muhammad Thoriq Al Fath Rivaldi Sidabutar |
| author_facet | Nisaul Fadilah Dalimunthe Sang Kompiang Wirawan Michael Michael Thiodorus Marvin Tjandra Muhammad Thoriq Al Fath Rivaldi Sidabutar |
| author_sort | Nisaul Fadilah Dalimunthe |
| collection | DOAJ |
| description | Pectin-based films incorporating carbonate hydroxyapatite (CHA) as a cinnamaldehyde carrier present a novel approach to oral drug delivery, addressing the limitations of pectin's hydrophilicity while leveraging CHA's porosity and adsorption capabilities to enhance controlled release properties. This study investigated CHA incorporation at various concentrations (0 %, 1 %, 3 %, 5 %, 7 % w/w). CHA addition increased film thickness (0.054–0.079 mm) and tensile strength (0.0081–0.0153 MPa), while reducing elongation (11.833 %–7.20 %) and swelling (231 %–192 %). FTIR and SEM analyses confirmed successful drug incorporation and structural modifications. Drug release kinetics demonstrated slower release profiles and lower diffusivity coefficients (De: 1.107 × 10−6 to 5.15 × 10−7 cm2/s) in pectin-CHA films, thus underscoring CHA's potential for enhancing controlled drug delivery. Cost analysis estimates promising financial viability, with a total production cost of 12,967 IDR/L yielding a profit of 17,525 IDR/L and a net profit of 4558 IDR/L, indicating strong potential for scale-up. This innovative approach not only addresses the challenges of sustainable and efficient oral drug delivery systems but also offers potential in structurally superior delivery system with targeted and sustained drug release capabilities. |
| format | Article |
| id | doaj-art-f52be7affdad4f11a1326ae45ab93f27 |
| institution | Kabale University |
| issn | 2666-0164 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Case Studies in Chemical and Environmental Engineering |
| spelling | doaj-art-f52be7affdad4f11a1326ae45ab93f272024-12-02T05:06:06ZengElsevierCase Studies in Chemical and Environmental Engineering2666-01642024-12-0110100905Pectin-carbonate hydroxyapatite composite films as a potential drug delivery system for cinnamaldehyde: Characterization and release kinetics modelingNisaul Fadilah Dalimunthe0Sang Kompiang Wirawan1Michael Michael2Thiodorus Marvin Tjandra3Muhammad Thoriq Al Fath4Rivaldi Sidabutar5Department of Chemical Engineering, Faculty of Engineering, Universitas Sumatera Utara, Medan, 20155, Indonesia; Corresponding author.Department of Chemical Engineering, Faculty of Engineering, Universitas Gadjah Mada, Yogyakarta, 55281, IndonesiaDepartment of Chemical Engineering, Faculty of Engineering, Universitas Sumatera Utara, Medan, 20155, IndonesiaDepartment of Chemical Engineering, Faculty of Engineering, Universitas Sumatera Utara, Medan, 20155, IndonesiaDepartment of Chemical Engineering, Faculty of Engineering, Universitas Sumatera Utara, Medan, 20155, IndonesiaDepartment of Chemical Engineering, Faculty of Engineering, Universitas Sumatera Utara, Medan, 20155, IndonesiaPectin-based films incorporating carbonate hydroxyapatite (CHA) as a cinnamaldehyde carrier present a novel approach to oral drug delivery, addressing the limitations of pectin's hydrophilicity while leveraging CHA's porosity and adsorption capabilities to enhance controlled release properties. This study investigated CHA incorporation at various concentrations (0 %, 1 %, 3 %, 5 %, 7 % w/w). CHA addition increased film thickness (0.054–0.079 mm) and tensile strength (0.0081–0.0153 MPa), while reducing elongation (11.833 %–7.20 %) and swelling (231 %–192 %). FTIR and SEM analyses confirmed successful drug incorporation and structural modifications. Drug release kinetics demonstrated slower release profiles and lower diffusivity coefficients (De: 1.107 × 10−6 to 5.15 × 10−7 cm2/s) in pectin-CHA films, thus underscoring CHA's potential for enhancing controlled drug delivery. Cost analysis estimates promising financial viability, with a total production cost of 12,967 IDR/L yielding a profit of 17,525 IDR/L and a net profit of 4558 IDR/L, indicating strong potential for scale-up. This innovative approach not only addresses the challenges of sustainable and efficient oral drug delivery systems but also offers potential in structurally superior delivery system with targeted and sustained drug release capabilities.http://www.sciencedirect.com/science/article/pii/S2666016424002998PectinCarbonate hydroxyapatiteCinnamaldehydeDrug delivery systemFilm |
| spellingShingle | Nisaul Fadilah Dalimunthe Sang Kompiang Wirawan Michael Michael Thiodorus Marvin Tjandra Muhammad Thoriq Al Fath Rivaldi Sidabutar Pectin-carbonate hydroxyapatite composite films as a potential drug delivery system for cinnamaldehyde: Characterization and release kinetics modeling Case Studies in Chemical and Environmental Engineering Pectin Carbonate hydroxyapatite Cinnamaldehyde Drug delivery system Film |
| title | Pectin-carbonate hydroxyapatite composite films as a potential drug delivery system for cinnamaldehyde: Characterization and release kinetics modeling |
| title_full | Pectin-carbonate hydroxyapatite composite films as a potential drug delivery system for cinnamaldehyde: Characterization and release kinetics modeling |
| title_fullStr | Pectin-carbonate hydroxyapatite composite films as a potential drug delivery system for cinnamaldehyde: Characterization and release kinetics modeling |
| title_full_unstemmed | Pectin-carbonate hydroxyapatite composite films as a potential drug delivery system for cinnamaldehyde: Characterization and release kinetics modeling |
| title_short | Pectin-carbonate hydroxyapatite composite films as a potential drug delivery system for cinnamaldehyde: Characterization and release kinetics modeling |
| title_sort | pectin carbonate hydroxyapatite composite films as a potential drug delivery system for cinnamaldehyde characterization and release kinetics modeling |
| topic | Pectin Carbonate hydroxyapatite Cinnamaldehyde Drug delivery system Film |
| url | http://www.sciencedirect.com/science/article/pii/S2666016424002998 |
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