Traumatic Brain Injury and Hypopituitarism
Results of recent and ongoing studies have made it clear that brain injuries like Traumatic Brian Injury (TBI) pose substantial risk to pituitary function, perhaps even greater risk than previously believed. Patients with TBI should be screened both prospectively and retrospectively for isolated, mu...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2005-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2005.100 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567141287591936 |
|---|---|
| author | Gianluca Aimaretti Ezio Ghigo |
| author_facet | Gianluca Aimaretti Ezio Ghigo |
| author_sort | Gianluca Aimaretti |
| collection | DOAJ |
| description | Results of recent and ongoing studies have made it clear that brain injuries like Traumatic Brian Injury (TBI) pose substantial risk to pituitary function, perhaps even greater risk than previously believed. Patients with TBI should be screened both prospectively and retrospectively for isolated, multiple and even total pituitary deficits. It is well known that, patients with “classical” hypopituitarism (due to primary hypothalamic-pituitary pathologies) do benefit from hormonal replacement therapy. It has been suggested that patients with TBI-induced hypopituitarism may benefit with appropriate hormonal replacement receiving replacement therapy such as anti-diuretic hormone (ADH), glucocorticoid and thyroid hormones when needed. Gonadal and recombinant human Growth Hormone (rhGH) replacement therapy should also be introduced if there are deficiencies demonstrated and even reconfirmed in a second step. The signs and symptoms of post-TBI hypopituitarism may be masked by what has been assumed to be merely the post-traumatic syndrome. By increasing awareness among physicians of the risks of brain injuries–induced endocrinopathies and the need for appropriate endocrinological testing, it may be possible to improve the quality of life and enhance the rehabilitation prospects for these patients. In most instances, these patients are first seen and treated by trauma surgeons and neurosurgeons, and subsequently by rehabilitation physicians; they must be knowledgeable about the risks of hypopituitarism so that they can determine which patients are candidates for screening for hypopituitarism. In addition, endocrinologists and internists must be educated about TBI-induced hypopituitarism and encouraged to actively share their expertise with other physicians. |
| format | Article |
| id | doaj-art-f527bdbeb4ba4fc986fa06378a7b4d22 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-f527bdbeb4ba4fc986fa06378a7b4d222025-02-03T01:02:17ZengWileyThe Scientific World Journal1537-744X2005-01-01577778110.1100/tsw.2005.100Traumatic Brain Injury and HypopituitarismGianluca Aimaretti0Ezio Ghigo1Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126,, Turin, ItalyDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126,, Turin, ItalyResults of recent and ongoing studies have made it clear that brain injuries like Traumatic Brian Injury (TBI) pose substantial risk to pituitary function, perhaps even greater risk than previously believed. Patients with TBI should be screened both prospectively and retrospectively for isolated, multiple and even total pituitary deficits. It is well known that, patients with “classical” hypopituitarism (due to primary hypothalamic-pituitary pathologies) do benefit from hormonal replacement therapy. It has been suggested that patients with TBI-induced hypopituitarism may benefit with appropriate hormonal replacement receiving replacement therapy such as anti-diuretic hormone (ADH), glucocorticoid and thyroid hormones when needed. Gonadal and recombinant human Growth Hormone (rhGH) replacement therapy should also be introduced if there are deficiencies demonstrated and even reconfirmed in a second step. The signs and symptoms of post-TBI hypopituitarism may be masked by what has been assumed to be merely the post-traumatic syndrome. By increasing awareness among physicians of the risks of brain injuries–induced endocrinopathies and the need for appropriate endocrinological testing, it may be possible to improve the quality of life and enhance the rehabilitation prospects for these patients. In most instances, these patients are first seen and treated by trauma surgeons and neurosurgeons, and subsequently by rehabilitation physicians; they must be knowledgeable about the risks of hypopituitarism so that they can determine which patients are candidates for screening for hypopituitarism. In addition, endocrinologists and internists must be educated about TBI-induced hypopituitarism and encouraged to actively share their expertise with other physicians.http://dx.doi.org/10.1100/tsw.2005.100 |
| spellingShingle | Gianluca Aimaretti Ezio Ghigo Traumatic Brain Injury and Hypopituitarism The Scientific World Journal |
| title | Traumatic Brain Injury and Hypopituitarism |
| title_full | Traumatic Brain Injury and Hypopituitarism |
| title_fullStr | Traumatic Brain Injury and Hypopituitarism |
| title_full_unstemmed | Traumatic Brain Injury and Hypopituitarism |
| title_short | Traumatic Brain Injury and Hypopituitarism |
| title_sort | traumatic brain injury and hypopituitarism |
| url | http://dx.doi.org/10.1100/tsw.2005.100 |
| work_keys_str_mv | AT gianlucaaimaretti traumaticbraininjuryandhypopituitarism AT ezioghigo traumaticbraininjuryandhypopituitarism |