Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents

Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents

Background: Reduced cortical inhibition mediated by GABA (gamma-aminobutyric acid) is reported in depression, anxiety disorders, and aging. A novel positive allosteric modulator that specifically targets the α5-GABAA receptor subunit (α5-PAM), ligand GL-II-73 shows anxiolytic, antidepressant, and pr...

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Bibliographic Details
Main Authors: Frank Mazza, Alexandre Guet-McCreight, Thomas D. Prevot, Taufik Valiante, Etienne Sibille, Etay Hay
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Biological Psychiatry Global Open Science
Subjects:
Biomarkers
Depression
Electroencephalography
Inhibition
Pharmacology
Rodents
Online Access:http://www.sciencedirect.com/science/article/pii/S2667174324001484
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