A Purely Biomanufactured System for Delivering Nanoparticles and STING Agonists
Abstract Nanovaccines have significantly contributed in the prevention and treatment of diseases. However, most of these technologies rely on chemical or hybrid semibiological synthesis methods, which limit the manufacturing performance advantages and improved inoculation outcomes compared with trad...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202408539 |
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| author | Yu‐an Li Yi Feng Wenjing Li Yuqin Zhang Yanni Sun Shifeng Wang Roy Curtiss III Huoying Shi |
| author_facet | Yu‐an Li Yi Feng Wenjing Li Yuqin Zhang Yanni Sun Shifeng Wang Roy Curtiss III Huoying Shi |
| author_sort | Yu‐an Li |
| collection | DOAJ |
| description | Abstract Nanovaccines have significantly contributed in the prevention and treatment of diseases. However, most of these technologies rely on chemical or hybrid semibiological synthesis methods, which limit the manufacturing performance advantages and improved inoculation outcomes compared with traditional vaccines. Herein, a universal and purely biological nanovaccine system is reported. This system integrates three modules: (1) self‐assembling nanoparticles, (2) self‐catalyzed synthesis of small‐molecule stimulator of interferon gene (STING) agonists, and (3) delivery vectors that target the cytosolic surveillance system. Various nanoparticles are efficiently self‐assembled using this system. After confirming the excellent immunostimulatory and lymph node targeting of this system, its broad‐spectrum antiviral efficacy is further demonstrated. By leveraging the comprehensive biosynthetic capabilities of bacterial cells, this system can efficiently combine various adjuvant‐active modular components and antigenic cargo, thereby providing a highly diversified and potent vaccine platform. |
| format | Article |
| id | doaj-art-f51600eb485c485cbbc6c10ccce52f44 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-f51600eb485c485cbbc6c10ccce52f442025-01-20T13:04:18ZengWileyAdvanced Science2198-38442025-01-01123n/an/a10.1002/advs.202408539A Purely Biomanufactured System for Delivering Nanoparticles and STING AgonistsYu‐an Li0Yi Feng1Wenjing Li2Yuqin Zhang3Yanni Sun4Shifeng Wang5Roy Curtiss III6Huoying Shi7College of Veterinary Medicine Yangzhou University Yangzhou Jiangsu 225009 ChinaCollege of Veterinary Medicine Yangzhou University Yangzhou Jiangsu 225009 ChinaCollege of Veterinary Medicine Yangzhou University Yangzhou Jiangsu 225009 ChinaCollege of Veterinary Medicine Yangzhou University Yangzhou Jiangsu 225009 ChinaCollege of Veterinary Medicine Yangzhou University Yangzhou Jiangsu 225009 ChinaDepartment of Infectious Diseases and Immunology College of Veterinary Medicine University of Florida Gainesville FL 32611‐0880 USADepartment of Infectious Diseases and Immunology College of Veterinary Medicine University of Florida Gainesville FL 32611‐0880 USACollege of Veterinary Medicine Yangzhou University Yangzhou Jiangsu 225009 ChinaAbstract Nanovaccines have significantly contributed in the prevention and treatment of diseases. However, most of these technologies rely on chemical or hybrid semibiological synthesis methods, which limit the manufacturing performance advantages and improved inoculation outcomes compared with traditional vaccines. Herein, a universal and purely biological nanovaccine system is reported. This system integrates three modules: (1) self‐assembling nanoparticles, (2) self‐catalyzed synthesis of small‐molecule stimulator of interferon gene (STING) agonists, and (3) delivery vectors that target the cytosolic surveillance system. Various nanoparticles are efficiently self‐assembled using this system. After confirming the excellent immunostimulatory and lymph node targeting of this system, its broad‐spectrum antiviral efficacy is further demonstrated. By leveraging the comprehensive biosynthetic capabilities of bacterial cells, this system can efficiently combine various adjuvant‐active modular components and antigenic cargo, thereby providing a highly diversified and potent vaccine platform.https://doi.org/10.1002/advs.202408539nanoparticlepurely biological systemSTING agonistuniversal vaccine |
| spellingShingle | Yu‐an Li Yi Feng Wenjing Li Yuqin Zhang Yanni Sun Shifeng Wang Roy Curtiss III Huoying Shi A Purely Biomanufactured System for Delivering Nanoparticles and STING Agonists Advanced Science nanoparticle purely biological system STING agonist universal vaccine |
| title | A Purely Biomanufactured System for Delivering Nanoparticles and STING Agonists |
| title_full | A Purely Biomanufactured System for Delivering Nanoparticles and STING Agonists |
| title_fullStr | A Purely Biomanufactured System for Delivering Nanoparticles and STING Agonists |
| title_full_unstemmed | A Purely Biomanufactured System for Delivering Nanoparticles and STING Agonists |
| title_short | A Purely Biomanufactured System for Delivering Nanoparticles and STING Agonists |
| title_sort | purely biomanufactured system for delivering nanoparticles and sting agonists |
| topic | nanoparticle purely biological system STING agonist universal vaccine |
| url | https://doi.org/10.1002/advs.202408539 |
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