The ChCl/HGA-based DES as a capable and new catalyst for the green synthesis of benzo[4,5]thiazolo[3,2-a]chromeno[4,3-d]pyrimidin-6-one
Abstract A novel deep eutectic solvent (ChCl/HGA-DES) was prepared by a mixture of two moles of choline chloride (ChCl) and one mole of 2,3-dihydroxybenzoic acid (hypogallic acid, HGA). The eutectic point phase diagram showed that the two moles of ChCl and one mole of HGA is the best molar ratio for...
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Nature Portfolio
2025-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-90953-w |
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| author | Elnaz Chegeni Davood Habibi Arezo Monem Zahra Jahaniyan |
| author_facet | Elnaz Chegeni Davood Habibi Arezo Monem Zahra Jahaniyan |
| author_sort | Elnaz Chegeni |
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| description | Abstract A novel deep eutectic solvent (ChCl/HGA-DES) was prepared by a mixture of two moles of choline chloride (ChCl) and one mole of 2,3-dihydroxybenzoic acid (hypogallic acid, HGA). The eutectic point phase diagram showed that the two moles of ChCl and one mole of HGA is the best molar ratio for synthesizing a novel DES. Then, ChCl/HGA-DES was characterized by the FT-IR, TGA/DTA, densitometer, eutectic points, and 1HNMR techniques and used as a novel and capable catalyst for the green synthesis of six new benzo[4,5]thiazolo[3,2-a]- chromeno[4,3-d]pyrimidin-6-ones 5(a-f) and five new (2-(2-hydroxyphenyl)-8-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-3-yl)(morpholino)methanones 6(a-e) through one-pot condensation reactions. |
| format | Article |
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| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-f4f6bd2a0ade47c5beed1482089b082a2025-08-20T02:59:20ZengNature PortfolioScientific Reports2045-23222025-03-0115111610.1038/s41598-025-90953-wThe ChCl/HGA-based DES as a capable and new catalyst for the green synthesis of benzo[4,5]thiazolo[3,2-a]chromeno[4,3-d]pyrimidin-6-oneElnaz Chegeni0Davood Habibi1Arezo Monem2Zahra Jahaniyan3Department of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityDepartment of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityDepartment of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityDepartment of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityAbstract A novel deep eutectic solvent (ChCl/HGA-DES) was prepared by a mixture of two moles of choline chloride (ChCl) and one mole of 2,3-dihydroxybenzoic acid (hypogallic acid, HGA). The eutectic point phase diagram showed that the two moles of ChCl and one mole of HGA is the best molar ratio for synthesizing a novel DES. Then, ChCl/HGA-DES was characterized by the FT-IR, TGA/DTA, densitometer, eutectic points, and 1HNMR techniques and used as a novel and capable catalyst for the green synthesis of six new benzo[4,5]thiazolo[3,2-a]- chromeno[4,3-d]pyrimidin-6-ones 5(a-f) and five new (2-(2-hydroxyphenyl)-8-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-3-yl)(morpholino)methanones 6(a-e) through one-pot condensation reactions.https://doi.org/10.1038/s41598-025-90953-w |
| spellingShingle | Elnaz Chegeni Davood Habibi Arezo Monem Zahra Jahaniyan The ChCl/HGA-based DES as a capable and new catalyst for the green synthesis of benzo[4,5]thiazolo[3,2-a]chromeno[4,3-d]pyrimidin-6-one Scientific Reports |
| title | The ChCl/HGA-based DES as a capable and new catalyst for the green synthesis of benzo[4,5]thiazolo[3,2-a]chromeno[4,3-d]pyrimidin-6-one |
| title_full | The ChCl/HGA-based DES as a capable and new catalyst for the green synthesis of benzo[4,5]thiazolo[3,2-a]chromeno[4,3-d]pyrimidin-6-one |
| title_fullStr | The ChCl/HGA-based DES as a capable and new catalyst for the green synthesis of benzo[4,5]thiazolo[3,2-a]chromeno[4,3-d]pyrimidin-6-one |
| title_full_unstemmed | The ChCl/HGA-based DES as a capable and new catalyst for the green synthesis of benzo[4,5]thiazolo[3,2-a]chromeno[4,3-d]pyrimidin-6-one |
| title_short | The ChCl/HGA-based DES as a capable and new catalyst for the green synthesis of benzo[4,5]thiazolo[3,2-a]chromeno[4,3-d]pyrimidin-6-one |
| title_sort | chcl hga based des as a capable and new catalyst for the green synthesis of benzo 4 5 thiazolo 3 2 a chromeno 4 3 d pyrimidin 6 one |
| url | https://doi.org/10.1038/s41598-025-90953-w |
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