Roles of METTL3 and NLRP3 in pyroptosis and prospects in SCIRI

Roles of METTL3 and NLRP3 in pyroptosis and prospects in SCIRI

Spinal cord ischemia-reperfusion injury (SCIRI) leads to severe neurological deficits, with pyroptosis emerging as a key driver of inflammation and neuronal death. Recent studies suggest that methyltransferase-like 3 (METTL3), a critical RNA methyltransferase, may regulate the nucleotide-binding oli...

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Bibliographic Details
Main Authors: Xiaoqing Guan, Fengyi Zhang, Ning Zhang, Guangchun Li, Fei Yin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
SCIRI
pyroptosis
NLRP3
METTL3
SCI
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1552704/full
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