Continuously Stirred Tank Reactor for Pharmaceutical and Chemical Applications
In the fields of drug synthesis and fine chemicals, the traditional kettle-type reactor with a small heat exchange area and the microreactor which is easy to clog, are not suitable for the reaction with fast reaction speed, large heat release, and high solid content. However, the continuously stirre...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Georg Thieme Verlag KG
2024-12-01
|
| Series: | Pharmaceutical Fronts |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1792036 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850132705713324032 |
|---|---|
| author | Junhua Li Yibo Zhou Hanqi Zhou Fengfan Liu Fuli Zhang |
| author_facet | Junhua Li Yibo Zhou Hanqi Zhou Fengfan Liu Fuli Zhang |
| author_sort | Junhua Li |
| collection | DOAJ |
| description | In the fields of drug synthesis and fine chemicals, the traditional kettle-type reactor with a small heat exchange area and the microreactor which is easy to clog, are not suitable for the reaction with fast reaction speed, large heat release, and high solid content. However, the continuously stirred reactor has the advantages of high mass and heat transfer efficiency, high reaction safety, and not easy to be clogged, and therefore, has a great potential for application. This paper reviews the research progress of continuous agitation reactors in organic synthesis, drug crystallization, and biocatalysis, hoping to provide a reference for applications of continuous agitation reactors in the pharmaceutical and chemical fields. |
| format | Article |
| id | doaj-art-f4ef7fd62a8d4283b8458f378dc7eb34 |
| institution | OA Journals |
| issn | 2628-5088 2628-5096 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Pharmaceutical Fronts |
| spelling | doaj-art-f4ef7fd62a8d4283b8458f378dc7eb342025-08-20T02:32:08ZengGeorg Thieme Verlag KGPharmaceutical Fronts2628-50882628-50962024-12-010604e382e39310.1055/s-0044-1792036Continuously Stirred Tank Reactor for Pharmaceutical and Chemical ApplicationsJunhua Li0Yibo Zhou1Hanqi Zhou2Fengfan Liu3Fuli Zhang4Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of ChinaKey Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of ChinaKey Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of ChinaKey Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of ChinaShanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, People's Republic of ChinaIn the fields of drug synthesis and fine chemicals, the traditional kettle-type reactor with a small heat exchange area and the microreactor which is easy to clog, are not suitable for the reaction with fast reaction speed, large heat release, and high solid content. However, the continuously stirred reactor has the advantages of high mass and heat transfer efficiency, high reaction safety, and not easy to be clogged, and therefore, has a great potential for application. This paper reviews the research progress of continuous agitation reactors in organic synthesis, drug crystallization, and biocatalysis, hoping to provide a reference for applications of continuous agitation reactors in the pharmaceutical and chemical fields.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1792036continuous stirred tank reactororganic synthesisdrug crystallizationbiocatalysis |
| spellingShingle | Junhua Li Yibo Zhou Hanqi Zhou Fengfan Liu Fuli Zhang Continuously Stirred Tank Reactor for Pharmaceutical and Chemical Applications Pharmaceutical Fronts continuous stirred tank reactor organic synthesis drug crystallization biocatalysis |
| title | Continuously Stirred Tank Reactor for Pharmaceutical and Chemical Applications |
| title_full | Continuously Stirred Tank Reactor for Pharmaceutical and Chemical Applications |
| title_fullStr | Continuously Stirred Tank Reactor for Pharmaceutical and Chemical Applications |
| title_full_unstemmed | Continuously Stirred Tank Reactor for Pharmaceutical and Chemical Applications |
| title_short | Continuously Stirred Tank Reactor for Pharmaceutical and Chemical Applications |
| title_sort | continuously stirred tank reactor for pharmaceutical and chemical applications |
| topic | continuous stirred tank reactor organic synthesis drug crystallization biocatalysis |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1792036 |
| work_keys_str_mv | AT junhuali continuouslystirredtankreactorforpharmaceuticalandchemicalapplications AT yibozhou continuouslystirredtankreactorforpharmaceuticalandchemicalapplications AT hanqizhou continuouslystirredtankreactorforpharmaceuticalandchemicalapplications AT fengfanliu continuouslystirredtankreactorforpharmaceuticalandchemicalapplications AT fulizhang continuouslystirredtankreactorforpharmaceuticalandchemicalapplications |