INVESTIGATING A TECHNOLOGY TO RESTORE SIGNAL TRANSMISSION ACROSS DEMYELINATED AXONS IN MULTIPLE SCLEROSIS: A COMPREHENSIVE REVIEW
Abstract. Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the degradation of myelin, a critical component of axons in the central nervous system (CNS). This demyelination disrupts signal transmission, leading to severe neurological impairments. Despite advancements in immun...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Odessa National Academy of Food Technologies
2025-04-01
|
| Series: | Автоматизация технологических и бизнес-процессов |
| Subjects: | |
| Online Access: | https://journals.ontu.edu.ua/index.php/atbp/article/view/3092 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850198285266976768 |
|---|---|
| author | Chathurika AGJ Hettige B Marikar FMMT |
| author_facet | Chathurika AGJ Hettige B Marikar FMMT |
| author_sort | Chathurika AGJ |
| collection | DOAJ |
| description | Abstract. Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the degradation of myelin, a critical component of axons in the central nervous system (CNS). This demyelination disrupts signal transmission, leading to severe neurological impairments. Despite advancements in immunomodulatory therapies, no existing treatments directly restore signal transmission across demyelinated axons. This comprehensive review explores emerging technologies designed to address this unmet need. We examine innovative approaches such as bioengineered myelin substitutes, nanotechnology-based interventions, and electrical stimulation techniques that aim to facilitate functional recovery. Additionally, advancements in stem cell therapies and pharmacological agents targeting remyelination are discussed in the context of preclinical and clinical studies. By synthesizing current research, this review highlights critical challenges, including biocompatibility, targeted delivery, and long-term efficacy, while identifying potential pathways for future innovation. The findings underscore the necessity of multidisciplinary collaboration to develop transformative therapies capable of restoring neurological function and improving quality of life for individuals with MS. |
| format | Article |
| id | doaj-art-f4ebdb68cf3347979b91dcbcaebeaf66 |
| institution | OA Journals |
| issn | 2312-3125 2312-931X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Odessa National Academy of Food Technologies |
| record_format | Article |
| series | Автоматизация технологических и бизнес-процессов |
| spelling | doaj-art-f4ebdb68cf3347979b91dcbcaebeaf662025-08-20T02:12:54ZengOdessa National Academy of Food TechnologiesАвтоматизация технологических и бизнес-процессов2312-31252312-931X2025-04-01171889710.15673/atbp.v17i1.30923092INVESTIGATING A TECHNOLOGY TO RESTORE SIGNAL TRANSMISSION ACROSS DEMYELINATED AXONS IN MULTIPLE SCLEROSIS: A COMPREHENSIVE REVIEWChathurika AGJHettige BMarikar FMMTAbstract. Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the degradation of myelin, a critical component of axons in the central nervous system (CNS). This demyelination disrupts signal transmission, leading to severe neurological impairments. Despite advancements in immunomodulatory therapies, no existing treatments directly restore signal transmission across demyelinated axons. This comprehensive review explores emerging technologies designed to address this unmet need. We examine innovative approaches such as bioengineered myelin substitutes, nanotechnology-based interventions, and electrical stimulation techniques that aim to facilitate functional recovery. Additionally, advancements in stem cell therapies and pharmacological agents targeting remyelination are discussed in the context of preclinical and clinical studies. By synthesizing current research, this review highlights critical challenges, including biocompatibility, targeted delivery, and long-term efficacy, while identifying potential pathways for future innovation. The findings underscore the necessity of multidisciplinary collaboration to develop transformative therapies capable of restoring neurological function and improving quality of life for individuals with MS.https://journals.ontu.edu.ua/index.php/atbp/article/view/3092demyelinationsignal transmissionmultiple sclerosisremyelinationneurorestoration |
| spellingShingle | Chathurika AGJ Hettige B Marikar FMMT INVESTIGATING A TECHNOLOGY TO RESTORE SIGNAL TRANSMISSION ACROSS DEMYELINATED AXONS IN MULTIPLE SCLEROSIS: A COMPREHENSIVE REVIEW Автоматизация технологических и бизнес-процессов demyelination signal transmission multiple sclerosis remyelination neurorestoration |
| title | INVESTIGATING A TECHNOLOGY TO RESTORE SIGNAL TRANSMISSION ACROSS DEMYELINATED AXONS IN MULTIPLE SCLEROSIS: A COMPREHENSIVE REVIEW |
| title_full | INVESTIGATING A TECHNOLOGY TO RESTORE SIGNAL TRANSMISSION ACROSS DEMYELINATED AXONS IN MULTIPLE SCLEROSIS: A COMPREHENSIVE REVIEW |
| title_fullStr | INVESTIGATING A TECHNOLOGY TO RESTORE SIGNAL TRANSMISSION ACROSS DEMYELINATED AXONS IN MULTIPLE SCLEROSIS: A COMPREHENSIVE REVIEW |
| title_full_unstemmed | INVESTIGATING A TECHNOLOGY TO RESTORE SIGNAL TRANSMISSION ACROSS DEMYELINATED AXONS IN MULTIPLE SCLEROSIS: A COMPREHENSIVE REVIEW |
| title_short | INVESTIGATING A TECHNOLOGY TO RESTORE SIGNAL TRANSMISSION ACROSS DEMYELINATED AXONS IN MULTIPLE SCLEROSIS: A COMPREHENSIVE REVIEW |
| title_sort | investigating a technology to restore signal transmission across demyelinated axons in multiple sclerosis a comprehensive review |
| topic | demyelination signal transmission multiple sclerosis remyelination neurorestoration |
| url | https://journals.ontu.edu.ua/index.php/atbp/article/view/3092 |
| work_keys_str_mv | AT chathurikaagj investigatingatechnologytorestoresignaltransmissionacrossdemyelinatedaxonsinmultiplesclerosisacomprehensivereview AT hettigeb investigatingatechnologytorestoresignaltransmissionacrossdemyelinatedaxonsinmultiplesclerosisacomprehensivereview AT marikarfmmt investigatingatechnologytorestoresignaltransmissionacrossdemyelinatedaxonsinmultiplesclerosisacomprehensivereview |