INVESTIGATING A TECHNOLOGY TO RESTORE SIGNAL TRANSMISSION ACROSS DEMYELINATED AXONS IN MULTIPLE SCLEROSIS: A COMPREHENSIVE REVIEW
Abstract. Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the degradation of myelin, a critical component of axons in the central nervous system (CNS). This demyelination disrupts signal transmission, leading to severe neurological impairments. Despite advancements in immun...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Odessa National Academy of Food Technologies
2025-04-01
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| Series: | Автоматизация технологических и бизнес-процессов |
| Subjects: | |
| Online Access: | https://journals.ontu.edu.ua/index.php/atbp/article/view/3092 |
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| Summary: | Abstract. Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the degradation of myelin, a critical component of axons in the central nervous system (CNS). This demyelination disrupts signal transmission, leading to severe neurological impairments. Despite advancements in immunomodulatory therapies, no existing treatments directly restore signal transmission across demyelinated axons. This comprehensive review explores emerging technologies designed to address this unmet need. We examine innovative approaches such as bioengineered myelin substitutes, nanotechnology-based interventions, and electrical stimulation techniques that aim to facilitate functional recovery. Additionally, advancements in stem cell therapies and pharmacological agents targeting remyelination are discussed in the context of preclinical and clinical studies. By synthesizing current research, this review highlights critical challenges, including biocompatibility, targeted delivery, and long-term efficacy, while identifying potential pathways for future innovation. The findings underscore the necessity of multidisciplinary collaboration to develop transformative therapies capable of restoring neurological function and improving quality of life for individuals with MS. |
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| ISSN: | 2312-3125 2312-931X |