PARP inhibition preserves cone photoreceptors in rd2 retina

PARP inhibition preserves cone photoreceptors in rd2 retina

Abstract The rd2 mouse model, characterized by a mutation in the Prph2 gene, exhibits abnormal development of photoreceptor outer segments, resulting in progressive retinal degeneration. While the correlation between poly-ADP-ribose polymerase (PARP) activity and the degeneration of rod photorecepto...

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Bibliographic Details
Main Authors: Pakize Nur Akkaya, María Miranda, Inmaculada Almansa, Cigdem Elmas, Dragana Trifunovic, Zohreh Hosseinzadeh, Ayse Sahaboglu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Acta Neuropathologica Communications
Subjects:
rd2 retinas
Photoreceptor cell death
PARP inhibition
Cone degeneration
Retinal inflammation
Online Access:https://doi.org/10.1186/s40478-025-01982-5
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