Brain metastasis from differentiated thyroid carcinoma responding to radioiodine therapy
Brain metastasis (BM) occurs only in about 1% of differentiated thyroid carcinoma (DTC) cases. Although DTC generally has a good prognosis, once BM develops, the mortality rate significantly increases up to 78%. BM is usually treated by surgical resection or external radiotherapy, whereas radioactiv...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2025-07-01
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| Series: | Asia Oceania Journal of Nuclear Medicine and Biology |
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| Online Access: | https://aojnmb.mums.ac.ir/article_25946_879705d895cc7c4aed3b5f5b775725ae.pdf |
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| _version_ | 1849419150576844800 |
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| author | Leo Hashimoto Shiro Watanabe Mungunkhuyag Majigsuren Kenji Hirata Junki Takenaka Rina Kimura Hiroshi Ishii Kohsuke Kudo |
| author_facet | Leo Hashimoto Shiro Watanabe Mungunkhuyag Majigsuren Kenji Hirata Junki Takenaka Rina Kimura Hiroshi Ishii Kohsuke Kudo |
| author_sort | Leo Hashimoto |
| collection | DOAJ |
| description | Brain metastasis (BM) occurs only in about 1% of differentiated thyroid carcinoma (DTC) cases. Although DTC generally has a good prognosis, once BM develops, the mortality rate significantly increases up to 78%. BM is usually treated by surgical resection or external radiotherapy, whereas radioactive iodine therapy (RAIT) using I-131 is much less often chosen because BM often shows poor uptake of I-131. In addition, even in case I-131 accumulates in the BM, RAIT could cause adverse effects such as brain hemorrhage and cerebral edema.
We present a case of BM from DTC that showed response to I-131 therapy with no severe adverse effects. The brain lesion was very small and asymptomatic, and was only found after a post-therapy I-131 scintigraphy. There are a few case reports where BM was cured by RAIT with little to no side effects. We theorize that BM that is small in size, asymptomatic and show I-131 accumulation could be successfully treated with RAIT. |
| format | Article |
| id | doaj-art-f4e6eae6d46d4172977e7b50dcb95370 |
| institution | Kabale University |
| issn | 2322-5718 2322-5726 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Asia Oceania Journal of Nuclear Medicine and Biology |
| spelling | doaj-art-f4e6eae6d46d4172977e7b50dcb953702025-08-20T03:32:14ZengMashhad University of Medical SciencesAsia Oceania Journal of Nuclear Medicine and Biology2322-57182322-57262025-07-0113220821210.22038/aojnmb.2025.86276.161825946Brain metastasis from differentiated thyroid carcinoma responding to radioiodine therapyLeo Hashimoto0Shiro Watanabe1Mungunkhuyag Majigsuren2Kenji Hirata3Junki Takenaka4Rina Kimura5Hiroshi Ishii6Kohsuke Kudo7Department of Nuclear Medicine, Hokkaido University Hospital, Sapporo, JapanDepartment of Nuclear Medicine, Hokkaido University Hospital, Sapporo, JapanDepartment of Diagnostic Imaging, Faculty of Medicine, Hokkaido University, Sapporo, JapanDepartment of Nuclear Medicine, Hokkaido University Hospital, Sapporo, JapanDepartment of Nuclear Medicine, Hokkaido University Hospital, Sapporo, JapanDepartment of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, JapanDepartment of Nuclear Medicine, Hokkaido University Hospital, Sapporo, JapanDepartment of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, JapanBrain metastasis (BM) occurs only in about 1% of differentiated thyroid carcinoma (DTC) cases. Although DTC generally has a good prognosis, once BM develops, the mortality rate significantly increases up to 78%. BM is usually treated by surgical resection or external radiotherapy, whereas radioactive iodine therapy (RAIT) using I-131 is much less often chosen because BM often shows poor uptake of I-131. In addition, even in case I-131 accumulates in the BM, RAIT could cause adverse effects such as brain hemorrhage and cerebral edema. We present a case of BM from DTC that showed response to I-131 therapy with no severe adverse effects. The brain lesion was very small and asymptomatic, and was only found after a post-therapy I-131 scintigraphy. There are a few case reports where BM was cured by RAIT with little to no side effects. We theorize that BM that is small in size, asymptomatic and show I-131 accumulation could be successfully treated with RAIT.https://aojnmb.mums.ac.ir/article_25946_879705d895cc7c4aed3b5f5b775725ae.pdfthyroid cancerradioiodinebrain metastasis |
| spellingShingle | Leo Hashimoto Shiro Watanabe Mungunkhuyag Majigsuren Kenji Hirata Junki Takenaka Rina Kimura Hiroshi Ishii Kohsuke Kudo Brain metastasis from differentiated thyroid carcinoma responding to radioiodine therapy Asia Oceania Journal of Nuclear Medicine and Biology thyroid cancer radioiodine brain metastasis |
| title | Brain metastasis from differentiated thyroid carcinoma responding to radioiodine therapy |
| title_full | Brain metastasis from differentiated thyroid carcinoma responding to radioiodine therapy |
| title_fullStr | Brain metastasis from differentiated thyroid carcinoma responding to radioiodine therapy |
| title_full_unstemmed | Brain metastasis from differentiated thyroid carcinoma responding to radioiodine therapy |
| title_short | Brain metastasis from differentiated thyroid carcinoma responding to radioiodine therapy |
| title_sort | brain metastasis from differentiated thyroid carcinoma responding to radioiodine therapy |
| topic | thyroid cancer radioiodine brain metastasis |
| url | https://aojnmb.mums.ac.ir/article_25946_879705d895cc7c4aed3b5f5b775725ae.pdf |
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