Preeclampsia Is Associated with Increased Central Aortic Pressure, Elastic Arteries Stiffness and Wave Reflections, and Resting and Recruitable Endothelial Dysfunction
Introduction. An altered endothelial function (EF) could be associated with preeclampsia (PE). However, more specific and complementary analyses are required to confirm this topic. Flow-mediated dilation (FMD), low-flow-mediated constriction (L-FMC), and hyperemic-related changes in carotid-radial p...
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| Format: | Article |
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Wiley
2015-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2015/720683 |
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| author | Juan Torrado Ignacio Farro Yanina Zócalo Federico Farro Claudio Sosa Santiago Scasso Justo Alonso Daniel Bia |
| author_facet | Juan Torrado Ignacio Farro Yanina Zócalo Federico Farro Claudio Sosa Santiago Scasso Justo Alonso Daniel Bia |
| author_sort | Juan Torrado |
| collection | DOAJ |
| description | Introduction. An altered endothelial function (EF) could be associated with preeclampsia (PE). However, more specific and complementary analyses are required to confirm this topic. Flow-mediated dilation (FMD), low-flow-mediated constriction (L-FMC), and hyperemic-related changes in carotid-radial pulse wave velocity (PWVcr) offer complementary information about “recruitability” of EF. Objectives. To evaluate, in healthy and hypertensive pregnant women (with and without PE), central arterial parameters in conjunction with “basal and recruitable” EF. Methods. Nonhypertensive (HP) and hypertensive pregnant women (gestational hypertension, GH; preeclampsia, PE) were included. Aortic blood pressure (BP), wave reflection parameters (AIx@75), aortic pulse wave velocity (PWVcf) and PWVcr, and brachial and common carotid stiffness and intima-media thickness were measured. Brachial FMD and L-FMC and hyperemic-related change in PWVcr were measured. Results. Aortic BP and AIx@75 were elevated in PE. PE showed stiffer elastic but not muscular arteries. After cuff deflation, PWVcr decreased in HP, while GH showed a blunted PWVcr response and PE showed a tendency to increase. Maximal FMD and L-FMC were observed in HP followed by GH; PE did not reach significant arterial constriction. Conclusion. Aortic BP and wave reflections as well as elastic arteries stiffness are increased in PE. PE showed both “resting and recruitable” endothelial dysfunctions. |
| format | Article |
| id | doaj-art-f4e4c3d941944faa8271fd5dca0329c0 |
| institution | OA Journals |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-f4e4c3d941944faa8271fd5dca0329c02025-08-20T02:22:10ZengWileyInternational Journal of Hypertension2090-03842090-03922015-01-01201510.1155/2015/720683720683Preeclampsia Is Associated with Increased Central Aortic Pressure, Elastic Arteries Stiffness and Wave Reflections, and Resting and Recruitable Endothelial DysfunctionJuan Torrado0Ignacio Farro1Yanina Zócalo2Federico Farro3Claudio Sosa4Santiago Scasso5Justo Alonso6Daniel Bia7Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Physiology Department, Faculty of Medicine, Republic University, 2125 General Flores, 11800 Montevideo, UruguayCentro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Physiology Department, Faculty of Medicine, Republic University, 2125 General Flores, 11800 Montevideo, UruguayCentro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Physiology Department, Faculty of Medicine, Republic University, 2125 General Flores, 11800 Montevideo, UruguayCentro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Physiology Department, Faculty of Medicine, Republic University, 2125 General Flores, 11800 Montevideo, UruguayDepartment of Obstetrics and Gynecology “C”, Pereira Rossell Hospital, Faculty of Medicine, Republic University, 1550 Bulevar Artigas, 11600 Montevideo, UruguayDepartment of Obstetrics and Gynecology “C”, Pereira Rossell Hospital, Faculty of Medicine, Republic University, 1550 Bulevar Artigas, 11600 Montevideo, UruguayDepartment of Obstetrics and Gynecology “C”, Pereira Rossell Hospital, Faculty of Medicine, Republic University, 1550 Bulevar Artigas, 11600 Montevideo, UruguayCentro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Physiology Department, Faculty of Medicine, Republic University, 2125 General Flores, 11800 Montevideo, UruguayIntroduction. An altered endothelial function (EF) could be associated with preeclampsia (PE). However, more specific and complementary analyses are required to confirm this topic. Flow-mediated dilation (FMD), low-flow-mediated constriction (L-FMC), and hyperemic-related changes in carotid-radial pulse wave velocity (PWVcr) offer complementary information about “recruitability” of EF. Objectives. To evaluate, in healthy and hypertensive pregnant women (with and without PE), central arterial parameters in conjunction with “basal and recruitable” EF. Methods. Nonhypertensive (HP) and hypertensive pregnant women (gestational hypertension, GH; preeclampsia, PE) were included. Aortic blood pressure (BP), wave reflection parameters (AIx@75), aortic pulse wave velocity (PWVcf) and PWVcr, and brachial and common carotid stiffness and intima-media thickness were measured. Brachial FMD and L-FMC and hyperemic-related change in PWVcr were measured. Results. Aortic BP and AIx@75 were elevated in PE. PE showed stiffer elastic but not muscular arteries. After cuff deflation, PWVcr decreased in HP, while GH showed a blunted PWVcr response and PE showed a tendency to increase. Maximal FMD and L-FMC were observed in HP followed by GH; PE did not reach significant arterial constriction. Conclusion. Aortic BP and wave reflections as well as elastic arteries stiffness are increased in PE. PE showed both “resting and recruitable” endothelial dysfunctions.http://dx.doi.org/10.1155/2015/720683 |
| spellingShingle | Juan Torrado Ignacio Farro Yanina Zócalo Federico Farro Claudio Sosa Santiago Scasso Justo Alonso Daniel Bia Preeclampsia Is Associated with Increased Central Aortic Pressure, Elastic Arteries Stiffness and Wave Reflections, and Resting and Recruitable Endothelial Dysfunction International Journal of Hypertension |
| title | Preeclampsia Is Associated with Increased Central Aortic Pressure, Elastic Arteries Stiffness and Wave Reflections, and Resting and Recruitable Endothelial Dysfunction |
| title_full | Preeclampsia Is Associated with Increased Central Aortic Pressure, Elastic Arteries Stiffness and Wave Reflections, and Resting and Recruitable Endothelial Dysfunction |
| title_fullStr | Preeclampsia Is Associated with Increased Central Aortic Pressure, Elastic Arteries Stiffness and Wave Reflections, and Resting and Recruitable Endothelial Dysfunction |
| title_full_unstemmed | Preeclampsia Is Associated with Increased Central Aortic Pressure, Elastic Arteries Stiffness and Wave Reflections, and Resting and Recruitable Endothelial Dysfunction |
| title_short | Preeclampsia Is Associated with Increased Central Aortic Pressure, Elastic Arteries Stiffness and Wave Reflections, and Resting and Recruitable Endothelial Dysfunction |
| title_sort | preeclampsia is associated with increased central aortic pressure elastic arteries stiffness and wave reflections and resting and recruitable endothelial dysfunction |
| url | http://dx.doi.org/10.1155/2015/720683 |
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