Esophageal neuroendocrine carcinoma: A clinical perspective on a rare and challenging disease
Neuroendocrine carcinomas (NECs) of the esophagus are exceptionally rare, comprising only 0.04% of all neuroendocrine tumors. These malignancies can remain asymptomatic or manifest through digestive symptoms such as dysphagia and abdominal discomfort. Due to their rarity, limited studies exist, resu...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043325002110 |
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| author | Benayad Aourarh Aziz Aourarh Lina Belkouchi Rachida Saouab Mohamed Amine Essaoudi |
| author_facet | Benayad Aourarh Aziz Aourarh Lina Belkouchi Rachida Saouab Mohamed Amine Essaoudi |
| author_sort | Benayad Aourarh |
| collection | DOAJ |
| description | Neuroendocrine carcinomas (NECs) of the esophagus are exceptionally rare, comprising only 0.04% of all neuroendocrine tumors. These malignancies can remain asymptomatic or manifest through digestive symptoms such as dysphagia and abdominal discomfort. Due to their rarity, limited studies exist, resulting in insufficient knowledge about their prognosis and treatment, with conflicting data in the literature.This report presents the case of a 62-year-old male chronic smoker with chronic dysphagia. Diagnostic evaluations, including gastroscopy and CT, revealed a circumferential lesion in the lower esophagus. Histopathological analysis confirmed a diagnosis of poorly differentiated large-cell neuroendocrine carcinoma.Esophageal NECs are aggressive and poorly understood tumors. Tumor size, lymph node involvement, and metastatic status are critical factors influencing treatment decisions. However, there are no established guidelines for their management. Extensive research is urgently needed to develop standardized treatment approaches and improve the prognosis of patients with high-grade esophageal NECs. |
| format | Article |
| id | doaj-art-f4e22a58d1784fcca13ec3d22ffeb1da |
| institution | OA Journals |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-f4e22a58d1784fcca13ec3d22ffeb1da2025-08-20T02:12:07ZengElsevierRadiology Case Reports1930-04332025-06-012063021302310.1016/j.radcr.2025.03.002Esophageal neuroendocrine carcinoma: A clinical perspective on a rare and challenging diseaseBenayad Aourarh0Aziz Aourarh1Lina Belkouchi2Rachida Saouab3Mohamed Amine Essaoudi4Department of Gastroenterology I, Mohammed V Military Hospital, Mohammed V University, Faculty of Medicine and Pharmacy of Rabat, Rabat, Morocco; Corresponding author.Department of Gastroenterology I, Mohammed V Military Hospital, Mohammed V University, Faculty of Medicine and Pharmacy of Rabat, Rabat, MoroccoDepartment of Radiology, Mohammed V Military Hospital, Mohammed V University, Faculty of Medicine and Pharmacy of Rabat, Rabat, MoroccoDepartment of Radiology, Mohammed V Military Hospital, Mohammed V University, Faculty of Medicine and Pharmacy of Rabat, Rabat, MoroccoDepartment of Pathology, Mohammed V Military Hospital, Mohammed V University, Faculty of medicine and Pharmacy of Rabat, Rabat, MoroccoNeuroendocrine carcinomas (NECs) of the esophagus are exceptionally rare, comprising only 0.04% of all neuroendocrine tumors. These malignancies can remain asymptomatic or manifest through digestive symptoms such as dysphagia and abdominal discomfort. Due to their rarity, limited studies exist, resulting in insufficient knowledge about their prognosis and treatment, with conflicting data in the literature.This report presents the case of a 62-year-old male chronic smoker with chronic dysphagia. Diagnostic evaluations, including gastroscopy and CT, revealed a circumferential lesion in the lower esophagus. Histopathological analysis confirmed a diagnosis of poorly differentiated large-cell neuroendocrine carcinoma.Esophageal NECs are aggressive and poorly understood tumors. Tumor size, lymph node involvement, and metastatic status are critical factors influencing treatment decisions. However, there are no established guidelines for their management. Extensive research is urgently needed to develop standardized treatment approaches and improve the prognosis of patients with high-grade esophageal NECs.http://www.sciencedirect.com/science/article/pii/S1930043325002110Neuroendocrine carcinomaEsophagusEndoscopyBiopsy |
| spellingShingle | Benayad Aourarh Aziz Aourarh Lina Belkouchi Rachida Saouab Mohamed Amine Essaoudi Esophageal neuroendocrine carcinoma: A clinical perspective on a rare and challenging disease Radiology Case Reports Neuroendocrine carcinoma Esophagus Endoscopy Biopsy |
| title | Esophageal neuroendocrine carcinoma: A clinical perspective on a rare and challenging disease |
| title_full | Esophageal neuroendocrine carcinoma: A clinical perspective on a rare and challenging disease |
| title_fullStr | Esophageal neuroendocrine carcinoma: A clinical perspective on a rare and challenging disease |
| title_full_unstemmed | Esophageal neuroendocrine carcinoma: A clinical perspective on a rare and challenging disease |
| title_short | Esophageal neuroendocrine carcinoma: A clinical perspective on a rare and challenging disease |
| title_sort | esophageal neuroendocrine carcinoma a clinical perspective on a rare and challenging disease |
| topic | Neuroendocrine carcinoma Esophagus Endoscopy Biopsy |
| url | http://www.sciencedirect.com/science/article/pii/S1930043325002110 |
| work_keys_str_mv | AT benayadaourarh esophagealneuroendocrinecarcinomaaclinicalperspectiveonarareandchallengingdisease AT azizaourarh esophagealneuroendocrinecarcinomaaclinicalperspectiveonarareandchallengingdisease AT linabelkouchi esophagealneuroendocrinecarcinomaaclinicalperspectiveonarareandchallengingdisease AT rachidasaouab esophagealneuroendocrinecarcinomaaclinicalperspectiveonarareandchallengingdisease AT mohamedamineessaoudi esophagealneuroendocrinecarcinomaaclinicalperspectiveonarareandchallengingdisease |