Laparoscopic versus open surgery for liver resection: a multicenter cohort study

Laparoscopic versus open surgery for liver resection: a multicenter cohort study

Abstract The relative risk and benefits of Laparoscopic liver resection (LLR) are still controversial. This study aimed to evaluate perioperative and survival outcomes for three primary malignant liver tumors related outcomes following LLR. Data from three Homogeneous-High-Volume-Expert-Centers were...

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Main Authors: Yesheng Li, Longrong Wang, Yibin Guo, Jiamin Zhou, Ning Zhang, Xigan He, Yixiu Wang, Weiping Zhu, Miao Wang, Hongxu Zhu, Zhiwen Ding, Yibin Wu, Ti Zhang, Qi Pan, Yun Feng, Zhenhai Lin, Anrong Mao, Yongfa Zhang, Yilin Wang, Bin Zhang, Yangqing Huang, Yiming Zhao, Lu Wang
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Hepatectomy
Laparoscopes
Complications
Liver neoplasms
Online Access:https://doi.org/10.1038/s41598-024-76260-w
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Summary:Abstract The relative risk and benefits of Laparoscopic liver resection (LLR) are still controversial. This study aimed to evaluate perioperative and survival outcomes for three primary malignant liver tumors related outcomes following LLR. Data from three Homogeneous-High-Volume-Expert-Centers were collected. Multivariable logistic regression analysis was performed for the association between LLR, and major complications defined as Clavien-Dindo Classification grade ≥ II. Multivariable Cox proportional hazards regression was used to explore the impact of LLR on primary malignant liver tumor survival. Overall, 5886 patients underwent liver resection, of which 1991 underwent LLR. After adjusting for covariables, LLR had significantly lower rate of CDC grade ≥ II (OR = 0.56, 95% CI: 0.48–0.67, P < 0.001). Interaction analysis showed that LLR had significant association with sex, drinking status, history of abdominal surgery, and platelet count (all P < 0.05). The overall survival for each primary malignant liver tumor shown potential risk but without significantly different between LLR and OLR (all P > 0.05). LLR was associated with lower rate of major complications, especially in women, non-drinkers, those without a history of abdominal surgery, and those with normal platelet. For primary malignant liver tumors, the survival outcomes did not differ significantly between LLR and OLR.
ISSN:2045-2322

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