SETD7 drives diabetic endothelial dysfunction through FBXO45-mediated GPX4 ubiquitylation

SETD7 drives diabetic endothelial dysfunction through FBXO45-mediated GPX4 ubiquitylation

Abstract Background Vasculopathy is the most prevalent complication of diabetes. Endothelial damage, a primary contributor to hyperglycemic vascular complications, impacts macro- and micro-vasculatures, causing functional impairment of multiple organs. SETD7 was initially identified as a transcripti...

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Bibliographic Details
Main Authors: Wen Zhong, Ruoxue Chen, Jialin Zhao, Yuyu Zhang, Jintao He, Huibin Wang, Feng Zhu, Chunxiang Fan, Xinhua Liu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cardiovascular Diabetology
Subjects:
Diabetic endothelial dysfunction
SETD7
p53
FBXO45
GPX4
Lipid peroxidation
Online Access:https://doi.org/10.1186/s12933-025-02740-6
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