A Randomized Controlled Trial of the Effect of 0.01% Atropine Eye Drops Combined with Auricular Acupoint Stimulation on Myopia Progression
Background. Use of 0.01% atropine eye drops (0.01% A) is one of the most common treatments for myopia control for children in Asia. Auricular acupoint stimulation (AAS) was reported to enhance the effect of higher-concentration atropine (0.25%, 0.125%) on myopia control. This study was designed to c...
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Wiley
2021-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2021/5585441 |
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| author | Xie-He Kong Yue Zhao Zhi Chen Li Zeng Rong Han Xiao-Qing Dong Xiao-Cong Guo Zheng Shi Guang Yang Yan-Ting Yang Dan Zhang Xing-Tao Zhou Xiao-Peng Ma |
| author_facet | Xie-He Kong Yue Zhao Zhi Chen Li Zeng Rong Han Xiao-Qing Dong Xiao-Cong Guo Zheng Shi Guang Yang Yan-Ting Yang Dan Zhang Xing-Tao Zhou Xiao-Peng Ma |
| author_sort | Xie-He Kong |
| collection | DOAJ |
| description | Background. Use of 0.01% atropine eye drops (0.01% A) is one of the most common treatments for myopia control for children in Asia. Auricular acupoint stimulation (AAS) was reported to enhance the effect of higher-concentration atropine (0.25%, 0.125%) on myopia control. This study was designed to compare the effect of 0.01% A combined with AAS and 0.01% A alone on myopia progression and choroidal thickness in children. Methods. A total of 104 children were stratified by age and randomly assigned at 1 : 1 to receive 0.01% A or 0.01% A + AAS treatment for 6 months. Repeated measurements of cycloplegic spherical equivalent (SE) autorefraction, axial length (AL), and choroidal thickness were performed at baseline, 1 month, 3 months, and 6 months. Results. The adjusted mean SE change over the 6 months was −0.38 ± 0.04 D in the 0.01% A group (n = 50) and −0.25 ± 0.04 D in the 0.01% A + AAS group (n = 50), demonstrating a significant between-group difference (P = 0.02). There was no statistically significant difference in the change of AL and choroidal thickness between the two groups (both P > 0.05). Conclusions. Adjunctive AAS compared with 0.01% A monotherapy slowed myopic progression in Chinese children by a statistically small amount, but had no effect on axial elongation and choroidal thickness during this 6-month observation. The trial is registered with ChiCTR1900021316. |
| format | Article |
| id | doaj-art-f4c0c98ae1a842b0bdc31c08131f8b7b |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-f4c0c98ae1a842b0bdc31c08131f8b7b2025-02-03T01:27:05ZengWileyJournal of Ophthalmology2090-004X2090-00582021-01-01202110.1155/2021/55854415585441A Randomized Controlled Trial of the Effect of 0.01% Atropine Eye Drops Combined with Auricular Acupoint Stimulation on Myopia ProgressionXie-He Kong0Yue Zhao1Zhi Chen2Li Zeng3Rong Han4Xiao-Qing Dong5Xiao-Cong Guo6Zheng Shi7Guang Yang8Yan-Ting Yang9Dan Zhang10Xing-Tao Zhou11Xiao-Peng Ma12Shanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, ChinaShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, ChinaDepartment of Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, ChinaDepartment of Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, ChinaShanghai University of Traditional Chinese Medicine, Shanghai 201210, ChinaShanghai University of Traditional Chinese Medicine, Shanghai 201210, ChinaShanghai University of Traditional Chinese Medicine, Shanghai 201210, ChinaShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, ChinaShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, ChinaShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, ChinaShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, ChinaDepartment of Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, ChinaShanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, ChinaBackground. Use of 0.01% atropine eye drops (0.01% A) is one of the most common treatments for myopia control for children in Asia. Auricular acupoint stimulation (AAS) was reported to enhance the effect of higher-concentration atropine (0.25%, 0.125%) on myopia control. This study was designed to compare the effect of 0.01% A combined with AAS and 0.01% A alone on myopia progression and choroidal thickness in children. Methods. A total of 104 children were stratified by age and randomly assigned at 1 : 1 to receive 0.01% A or 0.01% A + AAS treatment for 6 months. Repeated measurements of cycloplegic spherical equivalent (SE) autorefraction, axial length (AL), and choroidal thickness were performed at baseline, 1 month, 3 months, and 6 months. Results. The adjusted mean SE change over the 6 months was −0.38 ± 0.04 D in the 0.01% A group (n = 50) and −0.25 ± 0.04 D in the 0.01% A + AAS group (n = 50), demonstrating a significant between-group difference (P = 0.02). There was no statistically significant difference in the change of AL and choroidal thickness between the two groups (both P > 0.05). Conclusions. Adjunctive AAS compared with 0.01% A monotherapy slowed myopic progression in Chinese children by a statistically small amount, but had no effect on axial elongation and choroidal thickness during this 6-month observation. The trial is registered with ChiCTR1900021316.http://dx.doi.org/10.1155/2021/5585441 |
| spellingShingle | Xie-He Kong Yue Zhao Zhi Chen Li Zeng Rong Han Xiao-Qing Dong Xiao-Cong Guo Zheng Shi Guang Yang Yan-Ting Yang Dan Zhang Xing-Tao Zhou Xiao-Peng Ma A Randomized Controlled Trial of the Effect of 0.01% Atropine Eye Drops Combined with Auricular Acupoint Stimulation on Myopia Progression Journal of Ophthalmology |
| title | A Randomized Controlled Trial of the Effect of 0.01% Atropine Eye Drops Combined with Auricular Acupoint Stimulation on Myopia Progression |
| title_full | A Randomized Controlled Trial of the Effect of 0.01% Atropine Eye Drops Combined with Auricular Acupoint Stimulation on Myopia Progression |
| title_fullStr | A Randomized Controlled Trial of the Effect of 0.01% Atropine Eye Drops Combined with Auricular Acupoint Stimulation on Myopia Progression |
| title_full_unstemmed | A Randomized Controlled Trial of the Effect of 0.01% Atropine Eye Drops Combined with Auricular Acupoint Stimulation on Myopia Progression |
| title_short | A Randomized Controlled Trial of the Effect of 0.01% Atropine Eye Drops Combined with Auricular Acupoint Stimulation on Myopia Progression |
| title_sort | randomized controlled trial of the effect of 0 01 atropine eye drops combined with auricular acupoint stimulation on myopia progression |
| url | http://dx.doi.org/10.1155/2021/5585441 |
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