Rhamnan Sulfate from the Seaweed <i>Monostroma nitidum</i> May Improve Cognitive Impairment Caused by Hyperglycemia
Rhamnan sulfate (RS), extracted from the seaweed <i>Monostroma nitidum</i>, suppresses vascular endothelial inflammation and arteriosclerosis, decreases blood glucose levels, and improves blood lipid metabolism and the intestinal environment. We examined whether RS improves hyperglycemia...
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MDPI AG
2025-06-01
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| Series: | Marine Drugs |
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| author | Takaichi Miwa Masaya Sato Ning Ma Keiichi Hiramoto Masahiro Terasawa Koji Suzuki |
| author_facet | Takaichi Miwa Masaya Sato Ning Ma Keiichi Hiramoto Masahiro Terasawa Koji Suzuki |
| author_sort | Takaichi Miwa |
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| description | Rhamnan sulfate (RS), extracted from the seaweed <i>Monostroma nitidum</i>, suppresses vascular endothelial inflammation and arteriosclerosis, decreases blood glucose levels, and improves blood lipid metabolism and the intestinal environment. We examined whether RS improves hyperglycemia-induced cognitive decline in a hyperglycemic mouse model pretreated with nicotinamide and streptozotocin and then orally administered a high-fat diet and maltodextrin (MD) for 4 months. RS was administered in an MD solution at doses of 75, 225, and 750 mg/kg of mouse body weight. Administration of RS to hyperglycemic mice significantly reduced blood glucose levels and tended to improve memory function in behavioral pharmacological tests using spontaneous locomotor activity, rotarod test, and eight-way-maze test, although the results were not significant. Brain histopathological analysis showed that RS significantly reduced atrophy of neuronal layers in each region of the hippocampus compared with untreated hyperglycemic controls. RS also significantly suppressed TNF-α expression and microglial activation in the brain. These results suggest that RS intake suppresses inflammation in the brain and alleviates the cognitive impairment associated with hyperglycemic diabetes. |
| format | Article |
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| institution | Kabale University |
| issn | 1660-3397 |
| language | English |
| publishDate | 2025-06-01 |
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| series | Marine Drugs |
| spelling | doaj-art-f4bc65a2534544febbec2801ee8fe2852025-08-20T03:27:37ZengMDPI AGMarine Drugs1660-33972025-06-0123625010.3390/md23060250Rhamnan Sulfate from the Seaweed <i>Monostroma nitidum</i> May Improve Cognitive Impairment Caused by HyperglycemiaTakaichi Miwa0Masaya Sato1Ning Ma2Keiichi Hiramoto3Masahiro Terasawa4Koji Suzuki5Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Minamitamagakicho 3500-3, Suzuka 513-8670, Mie, JapanFaculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Minamitamagakicho 3500-3, Suzuka 513-8670, Mie, JapanGraduate School of Health Science, Suzuka University of Medical Science, Kishioka-cho 1275-3, Suzuka 510-0226, Mie, JapanFaculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Minamitamagakicho 3500-3, Suzuka 513-8670, Mie, JapanKonan Chemical Manufacturing Co., Ltd., Kitagomizuka, Kusu-cho, Yokkaichi 510-0103, Mie, JapanFaculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Minamitamagakicho 3500-3, Suzuka 513-8670, Mie, JapanRhamnan sulfate (RS), extracted from the seaweed <i>Monostroma nitidum</i>, suppresses vascular endothelial inflammation and arteriosclerosis, decreases blood glucose levels, and improves blood lipid metabolism and the intestinal environment. We examined whether RS improves hyperglycemia-induced cognitive decline in a hyperglycemic mouse model pretreated with nicotinamide and streptozotocin and then orally administered a high-fat diet and maltodextrin (MD) for 4 months. RS was administered in an MD solution at doses of 75, 225, and 750 mg/kg of mouse body weight. Administration of RS to hyperglycemic mice significantly reduced blood glucose levels and tended to improve memory function in behavioral pharmacological tests using spontaneous locomotor activity, rotarod test, and eight-way-maze test, although the results were not significant. Brain histopathological analysis showed that RS significantly reduced atrophy of neuronal layers in each region of the hippocampus compared with untreated hyperglycemic controls. RS also significantly suppressed TNF-α expression and microglial activation in the brain. These results suggest that RS intake suppresses inflammation in the brain and alleviates the cognitive impairment associated with hyperglycemic diabetes.https://www.mdpi.com/1660-3397/23/6/250diabetic cognitive impairmenthippocampal atrophymicrogliarhamnan sulfate<i>Monostroma nitidum</i> |
| spellingShingle | Takaichi Miwa Masaya Sato Ning Ma Keiichi Hiramoto Masahiro Terasawa Koji Suzuki Rhamnan Sulfate from the Seaweed <i>Monostroma nitidum</i> May Improve Cognitive Impairment Caused by Hyperglycemia Marine Drugs diabetic cognitive impairment hippocampal atrophy microglia rhamnan sulfate <i>Monostroma nitidum</i> |
| title | Rhamnan Sulfate from the Seaweed <i>Monostroma nitidum</i> May Improve Cognitive Impairment Caused by Hyperglycemia |
| title_full | Rhamnan Sulfate from the Seaweed <i>Monostroma nitidum</i> May Improve Cognitive Impairment Caused by Hyperglycemia |
| title_fullStr | Rhamnan Sulfate from the Seaweed <i>Monostroma nitidum</i> May Improve Cognitive Impairment Caused by Hyperglycemia |
| title_full_unstemmed | Rhamnan Sulfate from the Seaweed <i>Monostroma nitidum</i> May Improve Cognitive Impairment Caused by Hyperglycemia |
| title_short | Rhamnan Sulfate from the Seaweed <i>Monostroma nitidum</i> May Improve Cognitive Impairment Caused by Hyperglycemia |
| title_sort | rhamnan sulfate from the seaweed i monostroma nitidum i may improve cognitive impairment caused by hyperglycemia |
| topic | diabetic cognitive impairment hippocampal atrophy microglia rhamnan sulfate <i>Monostroma nitidum</i> |
| url | https://www.mdpi.com/1660-3397/23/6/250 |
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