Heterogeneous nuclear ribonucleoprotein H1 and its function in tumor development and metastasis
Heterogeneous nuclear ribonucleoprotein (hnRNP) and heterogeneous nuclear RNA (hnRNA) form complexes that regulate RNA splicing and transportation. hnRNPH1 is a member of the hnRNP family of proteins and plays an important role in physiological processes, including embryonic development of the nervo...
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Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
2024-12-01
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| Series: | Shanghai Jiaotong Daxue xuebao. Yixue ban |
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| Online Access: | https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-12-1615.shtml |
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| author | ZHANG Zongwen FENG Li FAN Zhisong |
| author_facet | ZHANG Zongwen FENG Li FAN Zhisong |
| author_sort | ZHANG Zongwen |
| collection | DOAJ |
| description | Heterogeneous nuclear ribonucleoprotein (hnRNP) and heterogeneous nuclear RNA (hnRNA) form complexes that regulate RNA splicing and transportation. hnRNPH1 is a member of the hnRNP family of proteins and plays an important role in physiological processes, including embryonic development of the nervous and reproductive systems. hnRNPH1 is highly expressed in various tumor tissues and tumor cells, and its overexpression correlates with poor prognosis in patients. hnRNPH1 enhances tumor cell proliferation and metastasis through the regulation of alternative splicing of genes, modulation of gene expression, formation of fusion genes with other genes, and involvement in epigenetic regulation.Recent studies have shown that hnRNPH1 could serve as a potential biomarker for certain tumors, and hnRNPH1-targeting drugs show preliminary efficacy in a mouse model of melanoma. This article reviews the role and research progress of hnRNPH1 in the initiation and progression of malignant tumors. |
| format | Article |
| id | doaj-art-f4ab16536bcd4906bb8ff4ddcd347039 |
| institution | Kabale University |
| issn | 1674-8115 |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) |
| record_format | Article |
| series | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| spelling | doaj-art-f4ab16536bcd4906bb8ff4ddcd3470392025-01-08T05:52:55ZzhoEditorial Office of Journal of Shanghai Jiao Tong University (Medical Science)Shanghai Jiaotong Daxue xuebao. Yixue ban1674-81152024-12-0144121615162010.3969/j.issn.1674-8115.2024.12.0161674-8115（2024）12-1615-06Heterogeneous nuclear ribonucleoprotein H1 and its function in tumor development and metastasisZHANG Zongwen0FENG Li1FAN Zhisong2Department of Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang050011, ChinaDepartment of Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang050011, ChinaDepartment of Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang050011, ChinaHeterogeneous nuclear ribonucleoprotein (hnRNP) and heterogeneous nuclear RNA (hnRNA) form complexes that regulate RNA splicing and transportation. hnRNPH1 is a member of the hnRNP family of proteins and plays an important role in physiological processes, including embryonic development of the nervous and reproductive systems. hnRNPH1 is highly expressed in various tumor tissues and tumor cells, and its overexpression correlates with poor prognosis in patients. hnRNPH1 enhances tumor cell proliferation and metastasis through the regulation of alternative splicing of genes, modulation of gene expression, formation of fusion genes with other genes, and involvement in epigenetic regulation.Recent studies have shown that hnRNPH1 could serve as a potential biomarker for certain tumors, and hnRNPH1-targeting drugs show preliminary efficacy in a mouse model of melanoma. This article reviews the role and research progress of hnRNPH1 in the initiation and progression of malignant tumors.https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-12-1615.shtmlhnrnph1tumorgenelncrnamirnaalternative splicing |
| spellingShingle | ZHANG Zongwen FENG Li FAN Zhisong Heterogeneous nuclear ribonucleoprotein H1 and its function in tumor development and metastasis Shanghai Jiaotong Daxue xuebao. Yixue ban hnrnph1 tumor gene lncrna mirna alternative splicing |
| title | Heterogeneous nuclear ribonucleoprotein H1 and its function in tumor development and metastasis |
| title_full | Heterogeneous nuclear ribonucleoprotein H1 and its function in tumor development and metastasis |
| title_fullStr | Heterogeneous nuclear ribonucleoprotein H1 and its function in tumor development and metastasis |
| title_full_unstemmed | Heterogeneous nuclear ribonucleoprotein H1 and its function in tumor development and metastasis |
| title_short | Heterogeneous nuclear ribonucleoprotein H1 and its function in tumor development and metastasis |
| title_sort | heterogeneous nuclear ribonucleoprotein h1 and its function in tumor development and metastasis |
| topic | hnrnph1 tumor gene lncrna mirna alternative splicing |
| url | https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-12-1615.shtml |
| work_keys_str_mv | AT zhangzongwen heterogeneousnuclearribonucleoproteinh1anditsfunctionintumordevelopmentandmetastasis AT fengli heterogeneousnuclearribonucleoproteinh1anditsfunctionintumordevelopmentandmetastasis AT fanzhisong heterogeneousnuclearribonucleoproteinh1anditsfunctionintumordevelopmentandmetastasis |