Effects of Cu(Ⅱ) stress on embryonic development, oxidative stress response, cholinergic system and energy metabolism in the Sepiella maindroni
In order to investigate the causes of population degradation and resource decline, this thesis investigated the ecotoxicological effects of heavy metal Cu(Ⅱ) on the embryonic development of Sepiella maindroni. Results indicate significant effects of Cu(Ⅱ) concentrations on the developmental toxicity...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325001113 |
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| author | Qilong Huang Jiawen Yu Ruibing Peng Maowang Jiang Qingxi Han Xiamin Jiang |
| author_facet | Qilong Huang Jiawen Yu Ruibing Peng Maowang Jiang Qingxi Han Xiamin Jiang |
| author_sort | Qilong Huang |
| collection | DOAJ |
| description | In order to investigate the causes of population degradation and resource decline, this thesis investigated the ecotoxicological effects of heavy metal Cu(Ⅱ) on the embryonic development of Sepiella maindroni. Results indicate significant effects of Cu(Ⅱ) concentrations on the developmental toxicity, teratogenicity, and lethality of S. maindroni embryos. Different concentrations of Cu(Ⅱ) caused varying degrees of malformations in embryos, altered developmental rates, reduced hatchability and hatchling quality, and increased malformation and mortality of hatchlings. At the same time, Cu(Ⅱ) exposure led to an increase in the content of the lipid peroxidation product malondialdehyde (MDA) and a significant decrease in the activity of antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT]), energy-metabolizing enzymes (adenylate kinase [AK]), and cholinergic-related enzymes (acetylcholinesterase [AChE], choline acetyltransferase [ChAT]). In conclusion, when the concentration of Cu(Ⅱ) in the environment is ≥ 0.01 mg/L, it causes significant lethality toxicity, developmental toxicity and teratogenicity in S. maindroni embryos. These effects are likely related to Cu(Ⅱ)-induced stress impacting the antioxidant capacity, energy metabolism, and cholinergic system. Ultimately, these toxic effects may lead to population degradation and resource decline in fishery organisms by affecting the early replenishment process of fisheries. |
| format | Article |
| id | doaj-art-f4a927a939544514a86bf0f1a649508b |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-f4a927a939544514a86bf0f1a649508b2025-02-12T05:30:19ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117775Effects of Cu(Ⅱ) stress on embryonic development, oxidative stress response, cholinergic system and energy metabolism in the Sepiella maindroniQilong Huang0Jiawen Yu1Ruibing Peng2Maowang Jiang3Qingxi Han4Xiamin Jiang5School of Marine Sciences, Ningbo University, Ningbo 315211, ChinaSchool of Marine Sciences, Ningbo University, Ningbo 315211, ChinaCorrespondence to: School of Marine Sciences, Ningbo University, 818 Fenghua Road, Ningbo 315211, China.; School of Marine Sciences, Ningbo University, Ningbo 315211, ChinaSchool of Marine Sciences, Ningbo University, Ningbo 315211, ChinaSchool of Marine Sciences, Ningbo University, Ningbo 315211, ChinaSchool of Marine Sciences, Ningbo University, Ningbo 315211, ChinaIn order to investigate the causes of population degradation and resource decline, this thesis investigated the ecotoxicological effects of heavy metal Cu(Ⅱ) on the embryonic development of Sepiella maindroni. Results indicate significant effects of Cu(Ⅱ) concentrations on the developmental toxicity, teratogenicity, and lethality of S. maindroni embryos. Different concentrations of Cu(Ⅱ) caused varying degrees of malformations in embryos, altered developmental rates, reduced hatchability and hatchling quality, and increased malformation and mortality of hatchlings. At the same time, Cu(Ⅱ) exposure led to an increase in the content of the lipid peroxidation product malondialdehyde (MDA) and a significant decrease in the activity of antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT]), energy-metabolizing enzymes (adenylate kinase [AK]), and cholinergic-related enzymes (acetylcholinesterase [AChE], choline acetyltransferase [ChAT]). In conclusion, when the concentration of Cu(Ⅱ) in the environment is ≥ 0.01 mg/L, it causes significant lethality toxicity, developmental toxicity and teratogenicity in S. maindroni embryos. These effects are likely related to Cu(Ⅱ)-induced stress impacting the antioxidant capacity, energy metabolism, and cholinergic system. Ultimately, these toxic effects may lead to population degradation and resource decline in fishery organisms by affecting the early replenishment process of fisheries.http://www.sciencedirect.com/science/article/pii/S0147651325001113Sepiella maindroniCu(Ⅱ)Growth performanceOxidative stressEnergy metabolism |
| spellingShingle | Qilong Huang Jiawen Yu Ruibing Peng Maowang Jiang Qingxi Han Xiamin Jiang Effects of Cu(Ⅱ) stress on embryonic development, oxidative stress response, cholinergic system and energy metabolism in the Sepiella maindroni Ecotoxicology and Environmental Safety Sepiella maindroni Cu(Ⅱ) Growth performance Oxidative stress Energy metabolism |
| title | Effects of Cu(Ⅱ) stress on embryonic development, oxidative stress response, cholinergic system and energy metabolism in the Sepiella maindroni |
| title_full | Effects of Cu(Ⅱ) stress on embryonic development, oxidative stress response, cholinergic system and energy metabolism in the Sepiella maindroni |
| title_fullStr | Effects of Cu(Ⅱ) stress on embryonic development, oxidative stress response, cholinergic system and energy metabolism in the Sepiella maindroni |
| title_full_unstemmed | Effects of Cu(Ⅱ) stress on embryonic development, oxidative stress response, cholinergic system and energy metabolism in the Sepiella maindroni |
| title_short | Effects of Cu(Ⅱ) stress on embryonic development, oxidative stress response, cholinergic system and energy metabolism in the Sepiella maindroni |
| title_sort | effects of cu ii stress on embryonic development oxidative stress response cholinergic system and energy metabolism in the sepiella maindroni |
| topic | Sepiella maindroni Cu(Ⅱ) Growth performance Oxidative stress Energy metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325001113 |
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