Trans-bronchial forceps biopsy for COVID-19 related diffuse parenchymal lung abnormalities
Abstract Purpose The role of lung biopsy for evaluation of persistent chest radiographic abnormalities including secondary organizing pneumonia (OP) in COVID-19 remains uncertain. This study aimed to evaluate the diagnostic value of trans-bronchial forceps biopsy (TBFB) in patients with persistent l...
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BMC
2024-12-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-024-03449-0 |
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| author | Janina Kleymann Sascha Brückmann Simona Langner Dirk Koschel Martin Kolditz |
| author_facet | Janina Kleymann Sascha Brückmann Simona Langner Dirk Koschel Martin Kolditz |
| author_sort | Janina Kleymann |
| collection | DOAJ |
| description | Abstract Purpose The role of lung biopsy for evaluation of persistent chest radiographic abnormalities including secondary organizing pneumonia (OP) in COVID-19 remains uncertain. This study aimed to evaluate the diagnostic value of trans-bronchial forceps biopsy (TBFB) in patients with persistent lung abnormalities on thoracic computed tomography (CT) scan following SARS-CoV-2 infection with particular focus on cases with OP and immunocompromised (IC) patients. Methods Descriptive retrospective single center analysis of all TBFB performed for diffuse lung parenchymal changes after COVID-19 03–2020 to 06–2023. Results Twenty seven consecutive TBFB including 23 in IC patients resulted in 100% samples with alveolar tissue showing a high frequency of 12/27 (44%) histological pattern of OP. Steroids were used in 21/27 patients (78%) including 11/12 (92%) with OP. Clinical outcome at discharge was favorable in 89% (92% with OP). Conclusion TBFB contributes to the diagnosis of diffuse parenchymal lung abnormalities in the context of COVID-19 including a frequent OP pattern particularly in IC patients. Larger studies are necessary to confirm our data and elucidate on the optimal steroid treatment modality. Trial registration Clinical trial number: not applicable. The study was approved by the Ethics Committee of the University Medicine Carl Gustav Carus, TU Dresden (BO-EK-309072023). Waiver of informed consent was granted because of the retrospective nature of the study. |
| format | Article |
| id | doaj-art-f4a7f7a8372f4e45907612543b22017e |
| institution | DOAJ |
| issn | 1471-2466 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
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| series | BMC Pulmonary Medicine |
| spelling | doaj-art-f4a7f7a8372f4e45907612543b22017e2025-08-20T02:57:39ZengBMCBMC Pulmonary Medicine1471-24662024-12-012411810.1186/s12890-024-03449-0Trans-bronchial forceps biopsy for COVID-19 related diffuse parenchymal lung abnormalitiesJanina Kleymann0Sascha Brückmann1Simona Langner2Dirk Koschel3Martin Kolditz4Medical Department I, Division of Pneumology, University Hospital Carl Gustav Carus, TU DresdenInstitute of Pathology and Tumor- and Normal Tissue Bank of the University Cancer Center (UCC), University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität DresdenMedical Department I, Division of Pneumology, University Hospital Carl Gustav Carus, TU DresdenMedical Department I, Division of Pneumology, University Hospital Carl Gustav Carus, TU DresdenMedical Department I, Division of Pneumology, University Hospital Carl Gustav Carus, TU DresdenAbstract Purpose The role of lung biopsy for evaluation of persistent chest radiographic abnormalities including secondary organizing pneumonia (OP) in COVID-19 remains uncertain. This study aimed to evaluate the diagnostic value of trans-bronchial forceps biopsy (TBFB) in patients with persistent lung abnormalities on thoracic computed tomography (CT) scan following SARS-CoV-2 infection with particular focus on cases with OP and immunocompromised (IC) patients. Methods Descriptive retrospective single center analysis of all TBFB performed for diffuse lung parenchymal changes after COVID-19 03–2020 to 06–2023. Results Twenty seven consecutive TBFB including 23 in IC patients resulted in 100% samples with alveolar tissue showing a high frequency of 12/27 (44%) histological pattern of OP. Steroids were used in 21/27 patients (78%) including 11/12 (92%) with OP. Clinical outcome at discharge was favorable in 89% (92% with OP). Conclusion TBFB contributes to the diagnosis of diffuse parenchymal lung abnormalities in the context of COVID-19 including a frequent OP pattern particularly in IC patients. Larger studies are necessary to confirm our data and elucidate on the optimal steroid treatment modality. Trial registration Clinical trial number: not applicable. The study was approved by the Ethics Committee of the University Medicine Carl Gustav Carus, TU Dresden (BO-EK-309072023). Waiver of informed consent was granted because of the retrospective nature of the study.https://doi.org/10.1186/s12890-024-03449-0Trans-bronchial biopsyCOVID-19 related lung changesOrganizing PneumoniaImmunocompromised |
| spellingShingle | Janina Kleymann Sascha Brückmann Simona Langner Dirk Koschel Martin Kolditz Trans-bronchial forceps biopsy for COVID-19 related diffuse parenchymal lung abnormalities BMC Pulmonary Medicine Trans-bronchial biopsy COVID-19 related lung changes Organizing Pneumonia Immunocompromised |
| title | Trans-bronchial forceps biopsy for COVID-19 related diffuse parenchymal lung abnormalities |
| title_full | Trans-bronchial forceps biopsy for COVID-19 related diffuse parenchymal lung abnormalities |
| title_fullStr | Trans-bronchial forceps biopsy for COVID-19 related diffuse parenchymal lung abnormalities |
| title_full_unstemmed | Trans-bronchial forceps biopsy for COVID-19 related diffuse parenchymal lung abnormalities |
| title_short | Trans-bronchial forceps biopsy for COVID-19 related diffuse parenchymal lung abnormalities |
| title_sort | trans bronchial forceps biopsy for covid 19 related diffuse parenchymal lung abnormalities |
| topic | Trans-bronchial biopsy COVID-19 related lung changes Organizing Pneumonia Immunocompromised |
| url | https://doi.org/10.1186/s12890-024-03449-0 |
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