Exercise during pregnancy modulates infant cellular and whole‐body adiposity
Abstract Non‐pharmaceutical interventions are needed to target the growing intergenerational cycle of obesity. We aimed to determine whether in utero exposure to different exercise doses during pregnancy directly reduces infant cellular and whole‐body adiposity. Pregnant women completed ~24 weeks of...
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Wiley
2024-12-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.70145 |
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| author | Alex Claiborne Filip Jevtovic Donghai Zheng Cody Strom Breanna Wisseman Samantha McDonald Edward Newton Steven Mouro James DeVente Joseph A. Houmard Nicholas T. Broskey Linda E. May |
| author_facet | Alex Claiborne Filip Jevtovic Donghai Zheng Cody Strom Breanna Wisseman Samantha McDonald Edward Newton Steven Mouro James DeVente Joseph A. Houmard Nicholas T. Broskey Linda E. May |
| author_sort | Alex Claiborne |
| collection | DOAJ |
| description | Abstract Non‐pharmaceutical interventions are needed to target the growing intergenerational cycle of obesity. We aimed to determine whether in utero exposure to different exercise doses during pregnancy directly reduces infant cellular and whole‐body adiposity. Pregnant women completed ~24 weeks of supervised exercise training; for standardization of exercise analysis (frequency, intensity, time, and volume‐FIT‐V), metrics were assessed from 16 to 36 weeks. Mesenchymal stem cells (MSC) collected from the umbilical cord at delivery underwent 21 days of adipogenic differentiation, then Oil Red O staining for lipid content. Infant body composition was measured at 1 month of age. ANCOVA and Pearson correlations determined the influence of prenatal exercise on infant adiposity. Exercise decreased infant MSC lipid content (p = 0.01) and body fat percentage (p = 0.009) irrespective of dose. Total exercise volume throughout pregnancy was negatively correlated with infant body fat % (R2 = 0.31, p = 0.02) due to lower subscapular skinfolds (R2 = 0.30, p = 0.02), while weekly exercise duration influenced adipogenic MSC lipid accumulation (R2 = −0.23, p = 0.03) and BF% (R2 = −0.15, p = 0.01). In utero exposure to exercise reduced cellular and whole‐body infant adiposity in a dose‐dependent manner. |
| format | Article |
| id | doaj-art-f4a7a48f37434732a9628f59988cc11a |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-f4a7a48f37434732a9628f59988cc11a2025-01-10T11:14:29ZengWileyPhysiological Reports2051-817X2024-12-011223n/an/a10.14814/phy2.70145Exercise during pregnancy modulates infant cellular and whole‐body adiposityAlex Claiborne0Filip Jevtovic1Donghai Zheng2Cody Strom3Breanna Wisseman4Samantha McDonald5Edward Newton6Steven Mouro7James DeVente8Joseph A. Houmard9Nicholas T. Broskey10Linda E. May11Department of Kinesiology East Carolina University (ECU) Greenville North Carolina USADepartment of Kinesiology East Carolina University (ECU) Greenville North Carolina USADepartment of Kinesiology East Carolina University (ECU) Greenville North Carolina USADepartment of Kinesiology and Sport University of Southern Indiana Evansville Indiana USADepartment of Kinesiology East Carolina University (ECU) Greenville North Carolina USASchool of Kinesiology and Recreation Illinois State University Normal Illinois USADepartment of Obstetrics & Gynecology East Carolina University Greenville North Carolina USADepartment of Obstetrics & Gynecology East Carolina University Greenville North Carolina USADepartment of Obstetrics & Gynecology East Carolina University Greenville North Carolina USADepartment of Kinesiology East Carolina University (ECU) Greenville North Carolina USADepartment of Kinesiology East Carolina University (ECU) Greenville North Carolina USADepartment of Kinesiology East Carolina University (ECU) Greenville North Carolina USAAbstract Non‐pharmaceutical interventions are needed to target the growing intergenerational cycle of obesity. We aimed to determine whether in utero exposure to different exercise doses during pregnancy directly reduces infant cellular and whole‐body adiposity. Pregnant women completed ~24 weeks of supervised exercise training; for standardization of exercise analysis (frequency, intensity, time, and volume‐FIT‐V), metrics were assessed from 16 to 36 weeks. Mesenchymal stem cells (MSC) collected from the umbilical cord at delivery underwent 21 days of adipogenic differentiation, then Oil Red O staining for lipid content. Infant body composition was measured at 1 month of age. ANCOVA and Pearson correlations determined the influence of prenatal exercise on infant adiposity. Exercise decreased infant MSC lipid content (p = 0.01) and body fat percentage (p = 0.009) irrespective of dose. Total exercise volume throughout pregnancy was negatively correlated with infant body fat % (R2 = 0.31, p = 0.02) due to lower subscapular skinfolds (R2 = 0.30, p = 0.02), while weekly exercise duration influenced adipogenic MSC lipid accumulation (R2 = −0.23, p = 0.03) and BF% (R2 = −0.15, p = 0.01). In utero exposure to exercise reduced cellular and whole‐body infant adiposity in a dose‐dependent manner.https://doi.org/10.14814/phy2.70145adiposeFIT‐Vmesenchymal stem celloffspringprenatal exercise |
| spellingShingle | Alex Claiborne Filip Jevtovic Donghai Zheng Cody Strom Breanna Wisseman Samantha McDonald Edward Newton Steven Mouro James DeVente Joseph A. Houmard Nicholas T. Broskey Linda E. May Exercise during pregnancy modulates infant cellular and whole‐body adiposity Physiological Reports adipose FIT‐V mesenchymal stem cell offspring prenatal exercise |
| title | Exercise during pregnancy modulates infant cellular and whole‐body adiposity |
| title_full | Exercise during pregnancy modulates infant cellular and whole‐body adiposity |
| title_fullStr | Exercise during pregnancy modulates infant cellular and whole‐body adiposity |
| title_full_unstemmed | Exercise during pregnancy modulates infant cellular and whole‐body adiposity |
| title_short | Exercise during pregnancy modulates infant cellular and whole‐body adiposity |
| title_sort | exercise during pregnancy modulates infant cellular and whole body adiposity |
| topic | adipose FIT‐V mesenchymal stem cell offspring prenatal exercise |
| url | https://doi.org/10.14814/phy2.70145 |
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