TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression
Abstract Tripartite motif-containing 21 (TRIM21) plays a crucial role in antiviral responses and autoimmune diseases. While the impact of TRIM21 on cancer has been studied in various tumors, its role in colorectal cancer (CRC) remains unclear. In this study, we found that TRIM21 expression is reduce...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-025-07383-9 |
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| _version_ | 1832571277699710976 |
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| author | Menghan Cao Zhiying Shao Xingyou Qian Miaolei Chen Chuyin Deng Xintian Chen Tingting Tang Kaixu Zhang Sufang Chu Junnian Zheng Jin Bai Zhongwei Li |
| author_facet | Menghan Cao Zhiying Shao Xingyou Qian Miaolei Chen Chuyin Deng Xintian Chen Tingting Tang Kaixu Zhang Sufang Chu Junnian Zheng Jin Bai Zhongwei Li |
| author_sort | Menghan Cao |
| collection | DOAJ |
| description | Abstract Tripartite motif-containing 21 (TRIM21) plays a crucial role in antiviral responses and autoimmune diseases. While the impact of TRIM21 on cancer has been studied in various tumors, its role in colorectal cancer (CRC) remains unclear. In this study, we found that TRIM21 expression is reduced in primary CRC tissues. Low levels of TRIM21 in CRC are associated with unfavorable clinicopathological characteristics and shorter survival. Furthermore, we demonstrate that TRIM21 suppresses the proliferation, tumorigenesis, migration, and metastasis of CRC cells by promoting the ubiquitination-mediated degradation of PRMT1. These findings suggest that TRIM21 holds potential as a valuable predictive biomarker for assessing the prognosis of CRC patients. |
| format | Article |
| id | doaj-art-f4814c066b644993b502232a43190cfb |
| institution | Kabale University |
| issn | 2041-4889 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj-art-f4814c066b644993b502232a43190cfb2025-02-02T12:44:53ZengNature Publishing GroupCell Death and Disease2041-48892025-01-0116111110.1038/s41419-025-07383-9TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progressionMenghan Cao0Zhiying Shao1Xingyou Qian2Miaolei Chen3Chuyin Deng4Xintian Chen5Tingting Tang6Kaixu Zhang7Sufang Chu8Junnian Zheng9Jin Bai10Zhongwei Li11Nanjing Medical UniversityCancer Institute, Xuzhou Medical UniversityCancer Institute, Xuzhou Medical UniversityCancer Institute, Xuzhou Medical UniversityCancer Institute, Xuzhou Medical UniversityDepartment of Gastroenterology, the Affiliated Hospital of Guangdong Medical UniversityCancer Institute, Xuzhou Medical UniversityLaboratory of Epigenetic Regulation in Molecular Medicine, School of Basic Medical Sciences, Wannan Medical CollegeCancer Institute, Xuzhou Medical UniversityNanjing Medical UniversityCancer Institute, Xuzhou Medical UniversityCancer Institute, Xuzhou Medical UniversityAbstract Tripartite motif-containing 21 (TRIM21) plays a crucial role in antiviral responses and autoimmune diseases. While the impact of TRIM21 on cancer has been studied in various tumors, its role in colorectal cancer (CRC) remains unclear. In this study, we found that TRIM21 expression is reduced in primary CRC tissues. Low levels of TRIM21 in CRC are associated with unfavorable clinicopathological characteristics and shorter survival. Furthermore, we demonstrate that TRIM21 suppresses the proliferation, tumorigenesis, migration, and metastasis of CRC cells by promoting the ubiquitination-mediated degradation of PRMT1. These findings suggest that TRIM21 holds potential as a valuable predictive biomarker for assessing the prognosis of CRC patients.https://doi.org/10.1038/s41419-025-07383-9 |
| spellingShingle | Menghan Cao Zhiying Shao Xingyou Qian Miaolei Chen Chuyin Deng Xintian Chen Tingting Tang Kaixu Zhang Sufang Chu Junnian Zheng Jin Bai Zhongwei Li TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression Cell Death and Disease |
| title | TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression |
| title_full | TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression |
| title_fullStr | TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression |
| title_full_unstemmed | TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression |
| title_short | TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression |
| title_sort | trim21 mediated prmt1 degradation attenuates colorectal cancer malignant progression |
| url | https://doi.org/10.1038/s41419-025-07383-9 |
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