Multiple Extracranial Metastases from Primary Gliosarcoma in a Patient with Two Previous Different Primary Cancers
Gliosarcoma (GS) constitutes a minor fraction of primary glioblastoma (GBM), which is the most frequent malignant brain tumor in adults. Despite the fact that malignant gliomas are highly invasive, extracranial metastases are very rarely seen, and the mechanisms behind extracranial dissemination are...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/7849616 |
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| author | T. Capion J. Hauerberg H. Broholm A. Muhic |
| author_facet | T. Capion J. Hauerberg H. Broholm A. Muhic |
| author_sort | T. Capion |
| collection | DOAJ |
| description | Gliosarcoma (GS) constitutes a minor fraction of primary glioblastoma (GBM), which is the most frequent malignant brain tumor in adults. Despite the fact that malignant gliomas are highly invasive, extracranial metastases are very rarely seen, and the mechanisms behind extracranial dissemination are still unclarified. We report a case of a 55-year-old male with a prior history of two distinct primary cancer types who, as a third independent type, developed GS with penetrating tumor growth to the skull and subcutaneous soft tissue via explosive spreading through a titanium net as well as extracranial metastases to the lumbar spine, paravertebral musculature, and most likely the right lung. The case illuminates the clinical challenge of diagnosing extracranial metastases from primary GBM and GS as these are still unexpected, especially in cases with possible competing diagnoses. |
| format | Article |
| id | doaj-art-f46a0d55a13f459397a8fde74d36f781 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-f46a0d55a13f459397a8fde74d36f7812025-02-03T06:12:11ZengWileyCase Reports in Oncological Medicine2090-67062090-67142019-01-01201910.1155/2019/78496167849616Multiple Extracranial Metastases from Primary Gliosarcoma in a Patient with Two Previous Different Primary CancersT. Capion0J. Hauerberg1H. Broholm2A. Muhic3Department of Neurosurgery, The Neuroscience Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, DenmarkDepartment of Neurosurgery, The Neuroscience Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, DenmarkDepartment of Pathology, Center of Diagnostic Investigation, Copenhagen University Hospital Rigshospitalet, Copenhagen, DenmarkDepartment of Oncology, The Finsen Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, DenmarkGliosarcoma (GS) constitutes a minor fraction of primary glioblastoma (GBM), which is the most frequent malignant brain tumor in adults. Despite the fact that malignant gliomas are highly invasive, extracranial metastases are very rarely seen, and the mechanisms behind extracranial dissemination are still unclarified. We report a case of a 55-year-old male with a prior history of two distinct primary cancer types who, as a third independent type, developed GS with penetrating tumor growth to the skull and subcutaneous soft tissue via explosive spreading through a titanium net as well as extracranial metastases to the lumbar spine, paravertebral musculature, and most likely the right lung. The case illuminates the clinical challenge of diagnosing extracranial metastases from primary GBM and GS as these are still unexpected, especially in cases with possible competing diagnoses.http://dx.doi.org/10.1155/2019/7849616 |
| spellingShingle | T. Capion J. Hauerberg H. Broholm A. Muhic Multiple Extracranial Metastases from Primary Gliosarcoma in a Patient with Two Previous Different Primary Cancers Case Reports in Oncological Medicine |
| title | Multiple Extracranial Metastases from Primary Gliosarcoma in a Patient with Two Previous Different Primary Cancers |
| title_full | Multiple Extracranial Metastases from Primary Gliosarcoma in a Patient with Two Previous Different Primary Cancers |
| title_fullStr | Multiple Extracranial Metastases from Primary Gliosarcoma in a Patient with Two Previous Different Primary Cancers |
| title_full_unstemmed | Multiple Extracranial Metastases from Primary Gliosarcoma in a Patient with Two Previous Different Primary Cancers |
| title_short | Multiple Extracranial Metastases from Primary Gliosarcoma in a Patient with Two Previous Different Primary Cancers |
| title_sort | multiple extracranial metastases from primary gliosarcoma in a patient with two previous different primary cancers |
| url | http://dx.doi.org/10.1155/2019/7849616 |
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