Mechanism of podophyllotoxin-induced ovarian toxicity via the AMPK/TSC1/mTOR/ULK1 axis in rats on the basis of toxicological evidence chain (TEC) concept

Mechanism of podophyllotoxin-induced ovarian toxicity via the AMPK/TSC1/mTOR/ULK1 axis in rats on the basis of toxicological evidence chain (TEC) concept

Background: Podophyllotoxin is a compound with clinical effects, such as anticancer and antiacromegaly effects, but its systemic toxicity has led to extremely limited clinical application. Methods: Using the toxicological evidence chain (TEC) as a research method, our team constructed, for the first...

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Bibliographic Details
Main Authors: Jingjing Li, Yanzhao Zhang, Mingyue Wei, Junjie He, Huifeng Ma, Zilong Chen, Jiajia Duan, Chuanxin Liu
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Podophyllotoxin
ovarian toxicity
toxicological evidence chain (TEC) concept
multiomics
AMPK/TSC1/mTOR/ULK1
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324016932
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