Jamblang (Syzygium cumini) leaf extract decreased hydrogen peroxide in lead acetate-induced rats
Background: Free radicals are atoms or molecules with one or more unpaired electrons. Lead acetate has been reported to increase the presence of free radicals in the body. Objective: This study aims to investigate the effect of oral administration of jamblang (Syzygium cumini) leaf extract on hy...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Indonesian Society for Biochemistry and Molecular Biology
2022-12-01
|
| Series: | Acta Biochimica Indonesiana |
| Subjects: | |
| Online Access: | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/118 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825199622559105024 |
|---|---|
| author | Rauza Sukma Rita Elmatris Sy Endrinaldi |
| author_facet | Rauza Sukma Rita Elmatris Sy Endrinaldi |
| author_sort | Rauza Sukma Rita |
| collection | DOAJ |
| description |
Background: Free radicals are atoms or molecules with one or more unpaired electrons. Lead acetate has been reported to increase the presence of free radicals in the body.
Objective: This study aims to investigate the effect of oral administration of jamblang (Syzygium cumini) leaf extract on hydrogen peroxide (H2O2) serum levels in rats induced with lead acetate.
Methods: A total of 24 male rats were divided into three groups: the negative control, the positive control, and the treatment group. The negative control group received a standard diet, the positive control group received lead acetate at a dose of 40 mg/kg body weight, and the treatment group received lead acetate at the same dose along with jamblang leaf extract at a dose of 150 mg/kg body weight. Lead acetate and jamblang leaf extract administration was carried out for 30 days. Afterward, serum H2O2 levels were examined using the colorimetry method.
Results: Results revealed that H2O2 levels in the negative control, positive control, and treatment groups were 3.08±0.24, 4.94±0.75, and 3.44±0.65 nmol/L, respectively. Significant differences were observed between the groups, as well as between the negative control and positive control, and between the positive control and treatment group.
Conclusion: The study showed that jamblang leaf extract can reduce hydrogen peroxide levels in Wistar rats treated with lead acetate, indicating its ability to address oxidative stress.
|
| format | Article |
| id | doaj-art-f45606e696a74203901cda40b574d2a6 |
| institution | Kabale University |
| issn | 2654-6108 2654-3222 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Indonesian Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | Acta Biochimica Indonesiana |
| spelling | doaj-art-f45606e696a74203901cda40b574d2a62025-02-08T03:05:56ZengIndonesian Society for Biochemistry and Molecular BiologyActa Biochimica Indonesiana2654-61082654-32222022-12-015210.32889/actabioina.118Jamblang (Syzygium cumini) leaf extract decreased hydrogen peroxide in lead acetate-induced ratsRauza Sukma Rita0Elmatris Sy1Endrinaldi2Department of Biochemistry Faculty of Medicine Universitas AndalasDepartment of Biochemistry Faculty of Medicine Universitas AndalasDepartment of Biochemistry Faculty of Medicine Universitas Andalas Background: Free radicals are atoms or molecules with one or more unpaired electrons. Lead acetate has been reported to increase the presence of free radicals in the body. Objective: This study aims to investigate the effect of oral administration of jamblang (Syzygium cumini) leaf extract on hydrogen peroxide (H2O2) serum levels in rats induced with lead acetate. Methods: A total of 24 male rats were divided into three groups: the negative control, the positive control, and the treatment group. The negative control group received a standard diet, the positive control group received lead acetate at a dose of 40 mg/kg body weight, and the treatment group received lead acetate at the same dose along with jamblang leaf extract at a dose of 150 mg/kg body weight. Lead acetate and jamblang leaf extract administration was carried out for 30 days. Afterward, serum H2O2 levels were examined using the colorimetry method. Results: Results revealed that H2O2 levels in the negative control, positive control, and treatment groups were 3.08±0.24, 4.94±0.75, and 3.44±0.65 nmol/L, respectively. Significant differences were observed between the groups, as well as between the negative control and positive control, and between the positive control and treatment group. Conclusion: The study showed that jamblang leaf extract can reduce hydrogen peroxide levels in Wistar rats treated with lead acetate, indicating its ability to address oxidative stress. https://pbbmi.org/newjurnal/index.php/actabioina/article/view/118hydrogen peroxideSyzygium cuminilead intoxication |
| spellingShingle | Rauza Sukma Rita Elmatris Sy Endrinaldi Jamblang (Syzygium cumini) leaf extract decreased hydrogen peroxide in lead acetate-induced rats Acta Biochimica Indonesiana hydrogen peroxide Syzygium cumini lead intoxication |
| title | Jamblang (Syzygium cumini) leaf extract decreased hydrogen peroxide in lead acetate-induced rats |
| title_full | Jamblang (Syzygium cumini) leaf extract decreased hydrogen peroxide in lead acetate-induced rats |
| title_fullStr | Jamblang (Syzygium cumini) leaf extract decreased hydrogen peroxide in lead acetate-induced rats |
| title_full_unstemmed | Jamblang (Syzygium cumini) leaf extract decreased hydrogen peroxide in lead acetate-induced rats |
| title_short | Jamblang (Syzygium cumini) leaf extract decreased hydrogen peroxide in lead acetate-induced rats |
| title_sort | jamblang syzygium cumini leaf extract decreased hydrogen peroxide in lead acetate induced rats |
| topic | hydrogen peroxide Syzygium cumini lead intoxication |
| url | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/118 |
| work_keys_str_mv | AT rauzasukmarita jamblangsyzygiumcuminileafextractdecreasedhydrogenperoxideinleadacetateinducedrats AT elmatrissy jamblangsyzygiumcuminileafextractdecreasedhydrogenperoxideinleadacetateinducedrats AT endrinaldi jamblangsyzygiumcuminileafextractdecreasedhydrogenperoxideinleadacetateinducedrats |