Animal-based evidence supports protective activity of bioengineered silver and gold nanomaterials on hepatic and renal function profile parameters
The liver and kidneys are vital organs responsible for essential metabolic and excretory functions, and their protection is a cornerstone of therapeutic innovation. This review highlights the emerging role of eco-friendly, bioengineered silver (AgNPs) and gold nanoparticles (AuNPs) as protective age...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nanotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnano.2024.1424562/full |
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| author | Hamed Barabadi Hesam Noqani Maha Soltani Ayeh Sabbagh Kashani |
| author_facet | Hamed Barabadi Hesam Noqani Maha Soltani Ayeh Sabbagh Kashani |
| author_sort | Hamed Barabadi |
| collection | DOAJ |
| description | The liver and kidneys are vital organs responsible for essential metabolic and excretory functions, and their protection is a cornerstone of therapeutic innovation. This review highlights the emerging role of eco-friendly, bioengineered silver (AgNPs) and gold nanoparticles (AuNPs) as protective agents for liver and kidney health, based on evidence from animal studies. The discussion emphasizes green synthesis approaches, which offer sustainable and biocompatible routes for nanoparticle production. Key findings reveal the effects of these nanoparticles (NPs) on hepatic enzymes—Aspartate aminotransferase (AST), Alanine transaminase (ALT), and Alkaline phosphatase (ALP)—and renal function markers, including urea and creatinine levels, under both healthy and pathological conditions. In diseased animal models, biosynthesized NPs significantly reduced ALT, AST, ALP, urea, and creatinine levels, demonstrating their protective effects. Conversely, in healthy animals, lower nanoparticle concentrations exhibited no statistically significant impact on these parameters, suggesting their safety at therapeutic doses. This review presents the novelty of bioengineered NPs as potential therapeutic agents for hepatic and renal protection while highlighting the need for further research into their pharmacokinetics and pharmacodynamics to advance clinical translation. |
| format | Article |
| id | doaj-art-f4543486d4d840c8a5664343f5b707da |
| institution | Kabale University |
| issn | 2673-3013 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nanotechnology |
| spelling | doaj-art-f4543486d4d840c8a5664343f5b707da2025-01-28T06:40:53ZengFrontiers Media S.A.Frontiers in Nanotechnology2673-30132025-01-01610.3389/fnano.2024.14245621424562Animal-based evidence supports protective activity of bioengineered silver and gold nanomaterials on hepatic and renal function profile parametersHamed Barabadi0Hesam Noqani1Maha Soltani2Ayeh Sabbagh Kashani3Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IranFaculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, IranThe liver and kidneys are vital organs responsible for essential metabolic and excretory functions, and their protection is a cornerstone of therapeutic innovation. This review highlights the emerging role of eco-friendly, bioengineered silver (AgNPs) and gold nanoparticles (AuNPs) as protective agents for liver and kidney health, based on evidence from animal studies. The discussion emphasizes green synthesis approaches, which offer sustainable and biocompatible routes for nanoparticle production. Key findings reveal the effects of these nanoparticles (NPs) on hepatic enzymes—Aspartate aminotransferase (AST), Alanine transaminase (ALT), and Alkaline phosphatase (ALP)—and renal function markers, including urea and creatinine levels, under both healthy and pathological conditions. In diseased animal models, biosynthesized NPs significantly reduced ALT, AST, ALP, urea, and creatinine levels, demonstrating their protective effects. Conversely, in healthy animals, lower nanoparticle concentrations exhibited no statistically significant impact on these parameters, suggesting their safety at therapeutic doses. This review presents the novelty of bioengineered NPs as potential therapeutic agents for hepatic and renal protection while highlighting the need for further research into their pharmacokinetics and pharmacodynamics to advance clinical translation.https://www.frontiersin.org/articles/10.3389/fnano.2024.1424562/fullsilver nanoparticlesgold nanoparticlesbiological synthesisliver protectionkidney protection |
| spellingShingle | Hamed Barabadi Hesam Noqani Maha Soltani Ayeh Sabbagh Kashani Animal-based evidence supports protective activity of bioengineered silver and gold nanomaterials on hepatic and renal function profile parameters Frontiers in Nanotechnology silver nanoparticles gold nanoparticles biological synthesis liver protection kidney protection |
| title | Animal-based evidence supports protective activity of bioengineered silver and gold nanomaterials on hepatic and renal function profile parameters |
| title_full | Animal-based evidence supports protective activity of bioengineered silver and gold nanomaterials on hepatic and renal function profile parameters |
| title_fullStr | Animal-based evidence supports protective activity of bioengineered silver and gold nanomaterials on hepatic and renal function profile parameters |
| title_full_unstemmed | Animal-based evidence supports protective activity of bioengineered silver and gold nanomaterials on hepatic and renal function profile parameters |
| title_short | Animal-based evidence supports protective activity of bioengineered silver and gold nanomaterials on hepatic and renal function profile parameters |
| title_sort | animal based evidence supports protective activity of bioengineered silver and gold nanomaterials on hepatic and renal function profile parameters |
| topic | silver nanoparticles gold nanoparticles biological synthesis liver protection kidney protection |
| url | https://www.frontiersin.org/articles/10.3389/fnano.2024.1424562/full |
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