Adaptive Immune Responses in Primary Cutaneous Sarcoidosis
Sarcoidosis is a multisystemic inflammatory disorder with cutaneous lesions present in about one-quarter of the patients. Cutaneous lesions have been classified as specific and nonspecific, depending on the presence of nonnecrotizing epithelial cell granulomas on histologic studies. The development...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/235142 |
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| author | Matteo Bordignon Paola Rottoli Carlo Agostini Mauro Alaibac |
| author_facet | Matteo Bordignon Paola Rottoli Carlo Agostini Mauro Alaibac |
| author_sort | Matteo Bordignon |
| collection | DOAJ |
| description | Sarcoidosis is a multisystemic inflammatory disorder with cutaneous lesions present in about one-quarter of the patients. Cutaneous lesions have been classified as specific and nonspecific, depending on the presence of nonnecrotizing epithelial cell granulomas on histologic studies. The development and progression of specific cutaneous sarcoidosis involves a complex interaction between cells of the adaptive immune systems, notably T-lymphocytes and dendritic cells. In this paper, we will discuss the role of T-cells and skin dendritic cells in the development of primary cutaneous sarcoidosis and comment on the potential antigenic stimuli that may account for the development of the immunological response. We will further explore the contributions of selected cytokines to the immunopathological process. The knowledge of the adaptive immunological mechanisms operative in cutaneous sarcoidosis may subsequently be useful for identifying prevention and treatment strategies of systemic sarcoidosis. |
| format | Article |
| id | doaj-art-f453565490f24e4ca95a0c1e28ba010b |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-f453565490f24e4ca95a0c1e28ba010b2025-02-03T01:13:09ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/235142235142Adaptive Immune Responses in Primary Cutaneous SarcoidosisMatteo Bordignon0Paola Rottoli1Carlo Agostini2Mauro Alaibac3Unit of Dermatology, University of Padua, Via Cesare Battisti 206, 35128 Padua, ItalyRespiratory Diseases Section, Department of Clinical Medicine and Immunological Sciences, Siena University, 53100 Siena, ItalyDepartment of Clinical and Experimental Medicine, University of Padua, Via Cesare Battisti 206, 35128 Padua, ItalyUnit of Dermatology, University of Padua, Via Cesare Battisti 206, 35128 Padua, ItalySarcoidosis is a multisystemic inflammatory disorder with cutaneous lesions present in about one-quarter of the patients. Cutaneous lesions have been classified as specific and nonspecific, depending on the presence of nonnecrotizing epithelial cell granulomas on histologic studies. The development and progression of specific cutaneous sarcoidosis involves a complex interaction between cells of the adaptive immune systems, notably T-lymphocytes and dendritic cells. In this paper, we will discuss the role of T-cells and skin dendritic cells in the development of primary cutaneous sarcoidosis and comment on the potential antigenic stimuli that may account for the development of the immunological response. We will further explore the contributions of selected cytokines to the immunopathological process. The knowledge of the adaptive immunological mechanisms operative in cutaneous sarcoidosis may subsequently be useful for identifying prevention and treatment strategies of systemic sarcoidosis.http://dx.doi.org/10.1155/2011/235142 |
| spellingShingle | Matteo Bordignon Paola Rottoli Carlo Agostini Mauro Alaibac Adaptive Immune Responses in Primary Cutaneous Sarcoidosis Clinical and Developmental Immunology |
| title | Adaptive Immune Responses in Primary Cutaneous Sarcoidosis |
| title_full | Adaptive Immune Responses in Primary Cutaneous Sarcoidosis |
| title_fullStr | Adaptive Immune Responses in Primary Cutaneous Sarcoidosis |
| title_full_unstemmed | Adaptive Immune Responses in Primary Cutaneous Sarcoidosis |
| title_short | Adaptive Immune Responses in Primary Cutaneous Sarcoidosis |
| title_sort | adaptive immune responses in primary cutaneous sarcoidosis |
| url | http://dx.doi.org/10.1155/2011/235142 |
| work_keys_str_mv | AT matteobordignon adaptiveimmuneresponsesinprimarycutaneoussarcoidosis AT paolarottoli adaptiveimmuneresponsesinprimarycutaneoussarcoidosis AT carloagostini adaptiveimmuneresponsesinprimarycutaneoussarcoidosis AT mauroalaibac adaptiveimmuneresponsesinprimarycutaneoussarcoidosis |