Challenges in Management of Ovotesticular Differences in Sex Development in Resource-Limited Settings
Differences in sex development (DSD) are congenital conditions in which the development of chromosomal, gonadal, or anatomical sex is atypical. Ovotesticular DSD is the rarest variant of DSD where both ovarian and testicular tissues co-exist in an individual. Ambiguous genitalia may be a glaring ind...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2024/9987144 |
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| author | Serwah Bonsu Asafo-Agyei Emmanuel Ameyaw Boateng Nimako Michael Amoah |
| author_facet | Serwah Bonsu Asafo-Agyei Emmanuel Ameyaw Boateng Nimako Michael Amoah |
| author_sort | Serwah Bonsu Asafo-Agyei |
| collection | DOAJ |
| description | Differences in sex development (DSD) are congenital conditions in which the development of chromosomal, gonadal, or anatomical sex is atypical. Ovotesticular DSD is the rarest variant of DSD where both ovarian and testicular tissues co-exist in an individual. Ambiguous genitalia may be a glaring indicator of DSD, but multiple genital anomalies should also raise a suspicion of DSD. This is a case report of a 15-year-6-month-old boy who presented during infancy with multiple genital anomalies requiring surgery. The diagnosis of ovotesticular DSD was missed until later in adolescence when he presented with progressive bilateral breast enlargement. Work-up revealed a 46, XX karyotype and dysgenetic testes, but functional ovarian tissue. The patient wanted to consider switching to a female gender but was constrained by psychosocial factors. Maintenance of a masculine phenotype was done using testosterone injections due to the relatively high cost of testosterone patches. Conclusion. Multiple genital anomalies should raise the suspicion of DSD, and prompt referral to an endocrinologist should be done before urogenital surgery and gender assignment are carried out. |
| format | Article |
| id | doaj-art-f450b34d9a744e1ebe4fd4fe1a882f6b |
| institution | Kabale University |
| issn | 2090-651X |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-f450b34d9a744e1ebe4fd4fe1a882f6b2025-02-03T01:29:25ZengWileyCase Reports in Endocrinology2090-651X2024-01-01202410.1155/2024/9987144Challenges in Management of Ovotesticular Differences in Sex Development in Resource-Limited SettingsSerwah Bonsu Asafo-Agyei0Emmanuel Ameyaw1Boateng Nimako2Michael Amoah3School of Medicine and DentistrySchool of Medicine and DentistryKomfo Anokye Teaching HospitalKomfo Anokye Teaching HospitalDifferences in sex development (DSD) are congenital conditions in which the development of chromosomal, gonadal, or anatomical sex is atypical. Ovotesticular DSD is the rarest variant of DSD where both ovarian and testicular tissues co-exist in an individual. Ambiguous genitalia may be a glaring indicator of DSD, but multiple genital anomalies should also raise a suspicion of DSD. This is a case report of a 15-year-6-month-old boy who presented during infancy with multiple genital anomalies requiring surgery. The diagnosis of ovotesticular DSD was missed until later in adolescence when he presented with progressive bilateral breast enlargement. Work-up revealed a 46, XX karyotype and dysgenetic testes, but functional ovarian tissue. The patient wanted to consider switching to a female gender but was constrained by psychosocial factors. Maintenance of a masculine phenotype was done using testosterone injections due to the relatively high cost of testosterone patches. Conclusion. Multiple genital anomalies should raise the suspicion of DSD, and prompt referral to an endocrinologist should be done before urogenital surgery and gender assignment are carried out.http://dx.doi.org/10.1155/2024/9987144 |
| spellingShingle | Serwah Bonsu Asafo-Agyei Emmanuel Ameyaw Boateng Nimako Michael Amoah Challenges in Management of Ovotesticular Differences in Sex Development in Resource-Limited Settings Case Reports in Endocrinology |
| title | Challenges in Management of Ovotesticular Differences in Sex Development in Resource-Limited Settings |
| title_full | Challenges in Management of Ovotesticular Differences in Sex Development in Resource-Limited Settings |
| title_fullStr | Challenges in Management of Ovotesticular Differences in Sex Development in Resource-Limited Settings |
| title_full_unstemmed | Challenges in Management of Ovotesticular Differences in Sex Development in Resource-Limited Settings |
| title_short | Challenges in Management of Ovotesticular Differences in Sex Development in Resource-Limited Settings |
| title_sort | challenges in management of ovotesticular differences in sex development in resource limited settings |
| url | http://dx.doi.org/10.1155/2024/9987144 |
| work_keys_str_mv | AT serwahbonsuasafoagyei challengesinmanagementofovotesticulardifferencesinsexdevelopmentinresourcelimitedsettings AT emmanuelameyaw challengesinmanagementofovotesticulardifferencesinsexdevelopmentinresourcelimitedsettings AT boatengnimako challengesinmanagementofovotesticulardifferencesinsexdevelopmentinresourcelimitedsettings AT michaelamoah challengesinmanagementofovotesticulardifferencesinsexdevelopmentinresourcelimitedsettings |