Analysis of the relative risk factors for H-type hypertension and its correlation with the MTHFR C677T genotype in a health checkup population in Urumqi, China—a cross-sectional study
Abstract Background This cross-sectional survey investigated the incidence of H-type hypertension and associated risk factors in a health checkup population in Urumqi, China. We aimed to identify potential intervention targets by screening patients with H-type hypertension and high-risk populations,...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-025-04926-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849335048944222208 |
|---|---|
| author | Na Li Xiaoping Yang Yuan Zou Jing Chen Yajing Cui Yunjie Teng Dan Yang Ayipali Aikemujiang Jianrong Wu |
| author_facet | Na Li Xiaoping Yang Yuan Zou Jing Chen Yajing Cui Yunjie Teng Dan Yang Ayipali Aikemujiang Jianrong Wu |
| author_sort | Na Li |
| collection | DOAJ |
| description | Abstract Background This cross-sectional survey investigated the incidence of H-type hypertension and associated risk factors in a health checkup population in Urumqi, China. We aimed to identify potential intervention targets by screening patients with H-type hypertension and high-risk populations, filling the gap in the risk assessment of H-type hypertension in high-altitude areas. Methods From January 2023 to January 2024, we conducted a cross-sectional study on 1,772 individuals who underwent methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism evaluations. We included a questionnaire survey and collected physical measurements and blood samples. The relative risk factors related to H-type hypertension, as well as their correlation with the MTHFR C677T genotype, were subsequently analyzed. Results H-type hypertension was present in 68.96% of hypertension cases and 17.55% of the population in Urumqi who underwent health checkups. The methylenetetrahydrofolate reductase (MTHFR) C677T distributions of the CC, CT, and TT genotypes were 11.90%, 39.87%, and 48.23%, respectively. Moreover, multivariate logistic regression identified the MTHFR C677T TT genotype, age, triglyceride-glucose index (TyG), and carotid plaques as risk factors related to H-type hypertension, with odds ratios (ORs) of 3.044 (p < 0.001), 1.041 (p = 0.001), 1.385 (p = 0.003), and 1.748 (p < 0.001), respectively. In addition, high-density lipoprotein (HDL) cholesterol was identified as a protective factor (OR = 0.447, p = 0.002). Through regression analysis, a nomogram model was constructed to predict the incidence of H-type hypertension. This model showed a good fit, and the area under the receiver operating characteristic (ROC) curve (AUC) was 0.760. Its predicted H-type hypertension incidence was closely related to the actual incidence. Conclusions According to our findings, the MTHFR C677T TT genotype in Urumqi, China, serves as a risk locus related to H-type hypertension. Moreover, age, TyG, and carotid plaques are risk factors for H-type hypertension, whereas HDL is a protective factor. |
| format | Article |
| id | doaj-art-f44f5771c00f4cedaca0c8c779c64ec3 |
| institution | Kabale University |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-f44f5771c00f4cedaca0c8c779c64ec32025-08-20T03:45:24ZengBMCBMC Cardiovascular Disorders1471-22612025-07-0125111110.1186/s12872-025-04926-yAnalysis of the relative risk factors for H-type hypertension and its correlation with the MTHFR C677T genotype in a health checkup population in Urumqi, China—a cross-sectional studyNa Li0Xiaoping Yang1Yuan Zou2Jing Chen3Yajing Cui4Yunjie Teng5Dan Yang6Ayipali Aikemujiang7Jianrong Wu8Health Management Center, First Affiliated Hospital of Xinjiang Medical UniversityHealth Management Center, First Affiliated Hospital of Xinjiang Medical UniversityHealth Management Center, First Affiliated Hospital of Xinjiang Medical UniversityHealth Management Center, First Affiliated Hospital of Xinjiang Medical UniversityHealth Management Center, First Affiliated Hospital of Xinjiang Medical UniversityHealth Management Center, First Affiliated Hospital of Xinjiang Medical UniversityHealth Management Center, First Affiliated Hospital of Xinjiang Medical UniversityHealth Management Center, First Affiliated Hospital of Xinjiang Medical UniversityHealth Management Center, First Affiliated Hospital of Xinjiang Medical UniversityAbstract Background This cross-sectional survey investigated the incidence of H-type hypertension and associated risk factors in a health checkup population in Urumqi, China. We aimed to identify potential intervention targets by screening patients with H-type hypertension and high-risk populations, filling the gap in the risk assessment of H-type hypertension in high-altitude areas. Methods From January 2023 to January 2024, we conducted a cross-sectional study on 1,772 individuals who underwent methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism evaluations. We included a questionnaire survey and collected physical measurements and blood samples. The relative risk factors related to H-type hypertension, as well as their correlation with the MTHFR C677T genotype, were subsequently analyzed. Results H-type hypertension was present in 68.96% of hypertension cases and 17.55% of the population in Urumqi who underwent health checkups. The methylenetetrahydrofolate reductase (MTHFR) C677T distributions of the CC, CT, and TT genotypes were 11.90%, 39.87%, and 48.23%, respectively. Moreover, multivariate logistic regression identified the MTHFR C677T TT genotype, age, triglyceride-glucose index (TyG), and carotid plaques as risk factors related to H-type hypertension, with odds ratios (ORs) of 3.044 (p < 0.001), 1.041 (p = 0.001), 1.385 (p = 0.003), and 1.748 (p < 0.001), respectively. In addition, high-density lipoprotein (HDL) cholesterol was identified as a protective factor (OR = 0.447, p = 0.002). Through regression analysis, a nomogram model was constructed to predict the incidence of H-type hypertension. This model showed a good fit, and the area under the receiver operating characteristic (ROC) curve (AUC) was 0.760. Its predicted H-type hypertension incidence was closely related to the actual incidence. Conclusions According to our findings, the MTHFR C677T TT genotype in Urumqi, China, serves as a risk locus related to H-type hypertension. Moreover, age, TyG, and carotid plaques are risk factors for H-type hypertension, whereas HDL is a protective factor.https://doi.org/10.1186/s12872-025-04926-yH-type hypertensionHyperhomocysteinemiaMTHFR C677TRisk factors |
| spellingShingle | Na Li Xiaoping Yang Yuan Zou Jing Chen Yajing Cui Yunjie Teng Dan Yang Ayipali Aikemujiang Jianrong Wu Analysis of the relative risk factors for H-type hypertension and its correlation with the MTHFR C677T genotype in a health checkup population in Urumqi, China—a cross-sectional study BMC Cardiovascular Disorders H-type hypertension Hyperhomocysteinemia MTHFR C677T Risk factors |
| title | Analysis of the relative risk factors for H-type hypertension and its correlation with the MTHFR C677T genotype in a health checkup population in Urumqi, China—a cross-sectional study |
| title_full | Analysis of the relative risk factors for H-type hypertension and its correlation with the MTHFR C677T genotype in a health checkup population in Urumqi, China—a cross-sectional study |
| title_fullStr | Analysis of the relative risk factors for H-type hypertension and its correlation with the MTHFR C677T genotype in a health checkup population in Urumqi, China—a cross-sectional study |
| title_full_unstemmed | Analysis of the relative risk factors for H-type hypertension and its correlation with the MTHFR C677T genotype in a health checkup population in Urumqi, China—a cross-sectional study |
| title_short | Analysis of the relative risk factors for H-type hypertension and its correlation with the MTHFR C677T genotype in a health checkup population in Urumqi, China—a cross-sectional study |
| title_sort | analysis of the relative risk factors for h type hypertension and its correlation with the mthfr c677t genotype in a health checkup population in urumqi china a cross sectional study |
| topic | H-type hypertension Hyperhomocysteinemia MTHFR C677T Risk factors |
| url | https://doi.org/10.1186/s12872-025-04926-y |
| work_keys_str_mv | AT nali analysisoftherelativeriskfactorsforhtypehypertensionanditscorrelationwiththemthfrc677tgenotypeinahealthcheckuppopulationinurumqichinaacrosssectionalstudy AT xiaopingyang analysisoftherelativeriskfactorsforhtypehypertensionanditscorrelationwiththemthfrc677tgenotypeinahealthcheckuppopulationinurumqichinaacrosssectionalstudy AT yuanzou analysisoftherelativeriskfactorsforhtypehypertensionanditscorrelationwiththemthfrc677tgenotypeinahealthcheckuppopulationinurumqichinaacrosssectionalstudy AT jingchen analysisoftherelativeriskfactorsforhtypehypertensionanditscorrelationwiththemthfrc677tgenotypeinahealthcheckuppopulationinurumqichinaacrosssectionalstudy AT yajingcui analysisoftherelativeriskfactorsforhtypehypertensionanditscorrelationwiththemthfrc677tgenotypeinahealthcheckuppopulationinurumqichinaacrosssectionalstudy AT yunjieteng analysisoftherelativeriskfactorsforhtypehypertensionanditscorrelationwiththemthfrc677tgenotypeinahealthcheckuppopulationinurumqichinaacrosssectionalstudy AT danyang analysisoftherelativeriskfactorsforhtypehypertensionanditscorrelationwiththemthfrc677tgenotypeinahealthcheckuppopulationinurumqichinaacrosssectionalstudy AT ayipaliaikemujiang analysisoftherelativeriskfactorsforhtypehypertensionanditscorrelationwiththemthfrc677tgenotypeinahealthcheckuppopulationinurumqichinaacrosssectionalstudy AT jianrongwu analysisoftherelativeriskfactorsforhtypehypertensionanditscorrelationwiththemthfrc677tgenotypeinahealthcheckuppopulationinurumqichinaacrosssectionalstudy |