Update on the Biological and Clinical Relevance of Mast Cells in Chronic Rhinosinusitis with Nasal Polyps
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disorder whose complex immunopathogenesis has yet to be fully elucidated. Endotype-2 CRSwNP is the most common form of disease where eosinophils are the main drivers of inflammation. Traditional treatments for CRSwNP have cen...
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2024-11-01
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| author | Luca Giovanni Locatello Silvia Tonon Vincenzo Mele Simone Santini Cesare Miani Carlo Ennio Michele Pucillo |
| author_facet | Luca Giovanni Locatello Silvia Tonon Vincenzo Mele Simone Santini Cesare Miani Carlo Ennio Michele Pucillo |
| author_sort | Luca Giovanni Locatello |
| collection | DOAJ |
| description | Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disorder whose complex immunopathogenesis has yet to be fully elucidated. Endotype-2 CRSwNP is the most common form of disease where eosinophils are the main drivers of inflammation. Traditional treatments for CRSwNP have centered around intranasal or systemic corticosteroids and endoscopic sinus surgery (ESS). However, recent advancements in targeted therapies have introduced novel biological agents that specifically target key inflammatory mediators such as IL-4, IL-5, and IL-13. These biologics offer promising options for patients with CRSwNP, particularly those who do not respond adequately to conventional treatments. Nonetheless, some patients do not satisfactorily respond to these drugs because of an insufficient blockade of the inflammatory process. The mast cell (MC) is another important (and somehow neglected) actor in the pathogenesis of CRSwNP, and the latest clinical and translational evidence in this field has been reviewed in the present paper. |
| format | Article |
| id | doaj-art-f44a5eee0c8a4a60b1746d9a2febc201 |
| institution | OA Journals |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-f44a5eee0c8a4a60b1746d9a2febc2012025-08-20T02:08:12ZengMDPI AGBiomedicines2227-90592024-11-011211264710.3390/biomedicines12112647Update on the Biological and Clinical Relevance of Mast Cells in Chronic Rhinosinusitis with Nasal PolypsLuca Giovanni Locatello0Silvia Tonon1Vincenzo Mele2Simone Santini3Cesare Miani4Carlo Ennio Michele Pucillo5Department of Otorhinolaryngology, Academic Hospital “Santa Maria della Misericordia”, Azienda Sanitaria Universitaria Friuli Centrale, Piazzale Santa Maria della Misericordia 15, 33100 Udine, ItalyDepartment of Medicine (DMED), Immunology Section, University of Udine, Piazzale Kolbe 4, 33100 Udine, ItalyDepartment of Otorhinolaryngology, Academic Hospital “Santa Maria della Misericordia”, Azienda Sanitaria Universitaria Friuli Centrale, Piazzale Santa Maria della Misericordia 15, 33100 Udine, ItalyDepartment of Otorhinolaryngology, Academic Hospital “Santa Maria della Misericordia”, Azienda Sanitaria Universitaria Friuli Centrale, Piazzale Santa Maria della Misericordia 15, 33100 Udine, ItalyDepartment of Otorhinolaryngology, Academic Hospital “Santa Maria della Misericordia”, Azienda Sanitaria Universitaria Friuli Centrale, Piazzale Santa Maria della Misericordia 15, 33100 Udine, ItalyDepartment of Medicine (DMED), Immunology Section, University of Udine, Piazzale Kolbe 4, 33100 Udine, ItalyChronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disorder whose complex immunopathogenesis has yet to be fully elucidated. Endotype-2 CRSwNP is the most common form of disease where eosinophils are the main drivers of inflammation. Traditional treatments for CRSwNP have centered around intranasal or systemic corticosteroids and endoscopic sinus surgery (ESS). However, recent advancements in targeted therapies have introduced novel biological agents that specifically target key inflammatory mediators such as IL-4, IL-5, and IL-13. These biologics offer promising options for patients with CRSwNP, particularly those who do not respond adequately to conventional treatments. Nonetheless, some patients do not satisfactorily respond to these drugs because of an insufficient blockade of the inflammatory process. The mast cell (MC) is another important (and somehow neglected) actor in the pathogenesis of CRSwNP, and the latest clinical and translational evidence in this field has been reviewed in the present paper.https://www.mdpi.com/2227-9059/12/11/2647nasal polypsmast cellsbiologicsrhinosinusitiseosinophils |
| spellingShingle | Luca Giovanni Locatello Silvia Tonon Vincenzo Mele Simone Santini Cesare Miani Carlo Ennio Michele Pucillo Update on the Biological and Clinical Relevance of Mast Cells in Chronic Rhinosinusitis with Nasal Polyps Biomedicines nasal polyps mast cells biologics rhinosinusitis eosinophils |
| title | Update on the Biological and Clinical Relevance of Mast Cells in Chronic Rhinosinusitis with Nasal Polyps |
| title_full | Update on the Biological and Clinical Relevance of Mast Cells in Chronic Rhinosinusitis with Nasal Polyps |
| title_fullStr | Update on the Biological and Clinical Relevance of Mast Cells in Chronic Rhinosinusitis with Nasal Polyps |
| title_full_unstemmed | Update on the Biological and Clinical Relevance of Mast Cells in Chronic Rhinosinusitis with Nasal Polyps |
| title_short | Update on the Biological and Clinical Relevance of Mast Cells in Chronic Rhinosinusitis with Nasal Polyps |
| title_sort | update on the biological and clinical relevance of mast cells in chronic rhinosinusitis with nasal polyps |
| topic | nasal polyps mast cells biologics rhinosinusitis eosinophils |
| url | https://www.mdpi.com/2227-9059/12/11/2647 |
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