Semi-Automated Graphical System for Calculating Pulmonary Vascular Impedances in a Clinical Setting
<italic>Goal:</italic> Create a semi-automated, graphical, stand-alone application that uses clinically available asynchronous pressure and Doppler velocity captures to rapidly calculate, display, and interpret the pulmonary vascular impedance (PVZ) spectra. <italic>Methods:</it...
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IEEE
2021-01-01
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| Series: | IEEE Open Journal of Engineering in Medicine and Biology |
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| Online Access: | https://ieeexplore.ieee.org/document/9424960/ |
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| author | Timothy Bachman Kang Kim Marc Simon |
| author_facet | Timothy Bachman Kang Kim Marc Simon |
| author_sort | Timothy Bachman |
| collection | DOAJ |
| description | <italic>Goal:</italic> Create a semi-automated, graphical, stand-alone application that uses clinically available asynchronous pressure and Doppler velocity captures to rapidly calculate, display, and interpret the pulmonary vascular impedance (PVZ) spectra. <italic>Methods:</italic> MATLAB-based software was written to analyze PVZ by creating a composite PVZ (cPVZ) spectra comprised of asynchronous screen captures of pulmonary arterial pressure and pulmonary arterial pulsed-wave Doppler velocity waveforms obtained during standard of care procedures. The pressure waveform, Doppler frequency envelopes, and ECG signals were re-digitized via automated border detection. cPVZ of averaged representative beats was calculated in the frequency domain via Fast Fourier Transform, and plotted vs harmonic z. <italic>Results:</italic> Successful generation of impedance spectra (PVZ(z)), where z is the harmonic, and additional parameters for characteristic impedance (Zc) and stiffness (Zs) were calculated as the mean of PVZ(2-4), and the sum of PVZ (1, 2), respectively. <italic>Conclusions:</italic> A graphically driven analysis of PVZ, calculated from standard of care right heart catheterization and echocardiography is possible. This system can help characterize both the steady and pulsatile components of right ventricular (RV) afterload in the clinical setting. |
| format | Article |
| id | doaj-art-f44170f4b6004815a3ee3fc3c2bbff3e |
| institution | Kabale University |
| issn | 2644-1276 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Open Journal of Engineering in Medicine and Biology |
| spelling | doaj-art-f44170f4b6004815a3ee3fc3c2bbff3e2025-08-20T03:32:47ZengIEEEIEEE Open Journal of Engineering in Medicine and Biology2644-12762021-01-01219820010.1109/OJEMB.2021.30767269424960Semi-Automated Graphical System for Calculating Pulmonary Vascular Impedances in a Clinical SettingTimothy Bachman0https://orcid.org/0000-0003-2046-5553Kang Kim1https://orcid.org/0000-0003-1966-1135Marc Simon2Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USADepartment of Bioengineering and Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USADepartment of Bioengineering and the Heart, Vascular Institute of University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA<italic>Goal:</italic> Create a semi-automated, graphical, stand-alone application that uses clinically available asynchronous pressure and Doppler velocity captures to rapidly calculate, display, and interpret the pulmonary vascular impedance (PVZ) spectra. <italic>Methods:</italic> MATLAB-based software was written to analyze PVZ by creating a composite PVZ (cPVZ) spectra comprised of asynchronous screen captures of pulmonary arterial pressure and pulmonary arterial pulsed-wave Doppler velocity waveforms obtained during standard of care procedures. The pressure waveform, Doppler frequency envelopes, and ECG signals were re-digitized via automated border detection. cPVZ of averaged representative beats was calculated in the frequency domain via Fast Fourier Transform, and plotted vs harmonic z. <italic>Results:</italic> Successful generation of impedance spectra (PVZ(z)), where z is the harmonic, and additional parameters for characteristic impedance (Zc) and stiffness (Zs) were calculated as the mean of PVZ(2-4), and the sum of PVZ (1, 2), respectively. <italic>Conclusions:</italic> A graphically driven analysis of PVZ, calculated from standard of care right heart catheterization and echocardiography is possible. This system can help characterize both the steady and pulsatile components of right ventricular (RV) afterload in the clinical setting.https://ieeexplore.ieee.org/document/9424960/Afterloadcharacteristic impedancehemodynamicspulmonary vascular impedancetotal pulmonary resistancevascular stiffness |
| spellingShingle | Timothy Bachman Kang Kim Marc Simon Semi-Automated Graphical System for Calculating Pulmonary Vascular Impedances in a Clinical Setting IEEE Open Journal of Engineering in Medicine and Biology Afterload characteristic impedance hemodynamics pulmonary vascular impedance total pulmonary resistance vascular stiffness |
| title | Semi-Automated Graphical System for Calculating Pulmonary Vascular Impedances in a Clinical Setting |
| title_full | Semi-Automated Graphical System for Calculating Pulmonary Vascular Impedances in a Clinical Setting |
| title_fullStr | Semi-Automated Graphical System for Calculating Pulmonary Vascular Impedances in a Clinical Setting |
| title_full_unstemmed | Semi-Automated Graphical System for Calculating Pulmonary Vascular Impedances in a Clinical Setting |
| title_short | Semi-Automated Graphical System for Calculating Pulmonary Vascular Impedances in a Clinical Setting |
| title_sort | semi automated graphical system for calculating pulmonary vascular impedances in a clinical setting |
| topic | Afterload characteristic impedance hemodynamics pulmonary vascular impedance total pulmonary resistance vascular stiffness |
| url | https://ieeexplore.ieee.org/document/9424960/ |
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