Association between metabolic score for insulin resistance and stroke: a nationally representative cross-sectional study from NHANES 2007–2018
BackgroundStroke is a significant cerebrovascular disease and remains one of the leading causes of death and disability worldwide. Insulin resistance has been strongly linked to the incidence of stroke. Employing characteristics of metabolic syndrome, the Metabolic Score for Insulin Resistance (METS...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1478884/full |
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| author | Lingtian Weng Yuqiu Lu Hanning Song Jiayi Xu Xuhong Jiang Xuhong Jiang |
| author_facet | Lingtian Weng Yuqiu Lu Hanning Song Jiayi Xu Xuhong Jiang Xuhong Jiang |
| author_sort | Lingtian Weng |
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| description | BackgroundStroke is a significant cerebrovascular disease and remains one of the leading causes of death and disability worldwide. Insulin resistance has been strongly linked to the incidence of stroke. Employing characteristics of metabolic syndrome, the Metabolic Score for Insulin Resistance (METS-IR) accurately measures insulin resistance. Nonetheless, the relationship between METS-IR and stroke risk is not well-established.MethodsWe analyzed data from the National Health and Nutrition Examination Survey (NHANES) covering the years 2007–2018. Participants providing complete METS-IR data and self-reported stroke information were included in the study. We utilized weighted multivariate regression to explore the relationship between METS-IR and stroke, performing subgroup analyses as well.ResultsA total of 14,794 participants were included, with an average METS-IR of 43.44 ± 12.68. The overall prevalence of self-reported stroke was 3.79%, with higher rates observed in upper METS-IR tertiles. An increase of one unit in METS-IR was associated with a 1% increase in stroke risk (OR = 1.01; 95% CI: 1.01–1.02). Interaction tests indicated no significant effects of gender, smoking status, alcohol consumption, hypertension, diabetes, physical activity, or serum cholesterol levels on this relationship. Notably, for participants younger than 60 years, the association was significantly stronger (OR = 1.02; 95% CI: 1.01–1.03), with a marked interaction (p = 0.0061).ConclusionOur findings indicate a positive correlation between higher METS-IR and increased stroke risk. Early intervention targeting insulin resistance may be a viable preventive measure against stroke, particularly in individuals under 60 years of age. |
| format | Article |
| id | doaj-art-f43cb81d3ccb4654a075701fa260240a |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-f43cb81d3ccb4654a075701fa260240a2025-01-03T05:10:19ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-01-011510.3389/fneur.2024.14788841478884Association between metabolic score for insulin resistance and stroke: a nationally representative cross-sectional study from NHANES 2007–2018Lingtian Weng0Yuqiu Lu1Hanning Song2Jiayi Xu3Xuhong Jiang4Xuhong Jiang5The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, ChinaThe Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, ChinaThe First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, ChinaThe First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, ChinaThe First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, ChinaGeneral Office, Office of the President, Development Planning Department, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, ChinaBackgroundStroke is a significant cerebrovascular disease and remains one of the leading causes of death and disability worldwide. Insulin resistance has been strongly linked to the incidence of stroke. Employing characteristics of metabolic syndrome, the Metabolic Score for Insulin Resistance (METS-IR) accurately measures insulin resistance. Nonetheless, the relationship between METS-IR and stroke risk is not well-established.MethodsWe analyzed data from the National Health and Nutrition Examination Survey (NHANES) covering the years 2007–2018. Participants providing complete METS-IR data and self-reported stroke information were included in the study. We utilized weighted multivariate regression to explore the relationship between METS-IR and stroke, performing subgroup analyses as well.ResultsA total of 14,794 participants were included, with an average METS-IR of 43.44 ± 12.68. The overall prevalence of self-reported stroke was 3.79%, with higher rates observed in upper METS-IR tertiles. An increase of one unit in METS-IR was associated with a 1% increase in stroke risk (OR = 1.01; 95% CI: 1.01–1.02). Interaction tests indicated no significant effects of gender, smoking status, alcohol consumption, hypertension, diabetes, physical activity, or serum cholesterol levels on this relationship. Notably, for participants younger than 60 years, the association was significantly stronger (OR = 1.02; 95% CI: 1.01–1.03), with a marked interaction (p = 0.0061).ConclusionOur findings indicate a positive correlation between higher METS-IR and increased stroke risk. Early intervention targeting insulin resistance may be a viable preventive measure against stroke, particularly in individuals under 60 years of age.https://www.frontiersin.org/articles/10.3389/fneur.2024.1478884/fullstrokemetabolic syndromeinsulin resistanceNHANEScross-sectional study |
| spellingShingle | Lingtian Weng Yuqiu Lu Hanning Song Jiayi Xu Xuhong Jiang Xuhong Jiang Association between metabolic score for insulin resistance and stroke: a nationally representative cross-sectional study from NHANES 2007–2018 Frontiers in Neurology stroke metabolic syndrome insulin resistance NHANES cross-sectional study |
| title | Association between metabolic score for insulin resistance and stroke: a nationally representative cross-sectional study from NHANES 2007–2018 |
| title_full | Association between metabolic score for insulin resistance and stroke: a nationally representative cross-sectional study from NHANES 2007–2018 |
| title_fullStr | Association between metabolic score for insulin resistance and stroke: a nationally representative cross-sectional study from NHANES 2007–2018 |
| title_full_unstemmed | Association between metabolic score for insulin resistance and stroke: a nationally representative cross-sectional study from NHANES 2007–2018 |
| title_short | Association between metabolic score for insulin resistance and stroke: a nationally representative cross-sectional study from NHANES 2007–2018 |
| title_sort | association between metabolic score for insulin resistance and stroke a nationally representative cross sectional study from nhanes 2007 2018 |
| topic | stroke metabolic syndrome insulin resistance NHANES cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1478884/full |
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