α-Synuclein fibrils enhance HIV-1 infection of human T cells, macrophages and microglia

α-Synuclein fibrils enhance HIV-1 infection of human T cells, macrophages and microglia

Abstract HIV-associated neurocognitive disorders (HAND) and viral reservoirs in the brain remain a significant challenge. Despite their importance, the mechanisms allowing HIV-1 entry and replication in the central nervous system (CNS) are poorly understood. Here, we show that α-synuclein and (to a...

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Main Authors: Lia-Raluca Olari, Sichen Liu, Franziska Arnold, Julia Kühlwein, Marta Gil Miró, Ajeet Rijal Updahaya, Christina Stürzel, Dietmar Rudolf Thal, Paul Walther, Konstantin M. J. Sparrer, Karin M. Danzer, Jan Münch, Frank Kirchhoff
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56099-z
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https://doi.org/10.1038/s41467-025-56099-z

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