Composite Based on Biomineralized Oxidized Bacterial Cellulose with Strontium Apatite for Bone Regeneration
Rejections of commercial bone implants have driven research in the biomaterials field to develop more biocompatible and less cytotoxic alternatives. This study aims to create composites based on oxidized bacterial cellulose (OBC) and strontium apatite (SrAp). These composites were produced through a...
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MDPI AG
2025-03-01
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| Series: | Polysaccharides |
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| Online Access: | https://www.mdpi.com/2673-4176/6/1/23 |
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| author | Ana Lorena de Brito Soares Erika Patrícia Chagas Gomes Luz Igor Iuco Castro-Silva Rodolpho Ramilton de Castro Monteiro Fábia Karine Andrade Rodrigo Silveira Vieira |
| author_facet | Ana Lorena de Brito Soares Erika Patrícia Chagas Gomes Luz Igor Iuco Castro-Silva Rodolpho Ramilton de Castro Monteiro Fábia Karine Andrade Rodrigo Silveira Vieira |
| author_sort | Ana Lorena de Brito Soares |
| collection | DOAJ |
| description | Rejections of commercial bone implants have driven research in the biomaterials field to develop more biocompatible and less cytotoxic alternatives. This study aims to create composites based on oxidized bacterial cellulose (OBC) and strontium apatite (SrAp). These composites were produced through a biomimetic method using a simulated body fluid modified with strontium ions to enhance bioactivity and stabilize apatite within the biomaterial. The incorporation of SrAp into OBC membranes was confirmed by infrared spectroscopy and indicated by the appearance of a peak corresponding to phosphate group elongation (850 cm<sup>−1</sup>). Quantification of strontium content by atomic absorption spectrometry revealed a concentration of 3359 ± 727 mg·g<sup>−1</sup> of Sr adsorbed onto the material surface after 7 days, beyond which no significant increase was observed. Scanning electron microscopy verified biomineralization through structural modifications, and X-ray diffraction showed that despite new peak appearances, the biomineralized membranes retained crystallinity similar to pure samples. The composite also demonstrated high cell viability for mouse osteoblasts and fibroblasts and a low mortality rate in brine shrimp Artemia (approximately 12.94 ± 4.77%). These findings suggest that these membranes have great potential for application in bone tissue engineering. |
| format | Article |
| id | doaj-art-f43511b95fea4035b2edc677474aba9e |
| institution | OA Journals |
| issn | 2673-4176 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polysaccharides |
| spelling | doaj-art-f43511b95fea4035b2edc677474aba9e2025-08-20T01:49:01ZengMDPI AGPolysaccharides2673-41762025-03-01612310.3390/polysaccharides6010023Composite Based on Biomineralized Oxidized Bacterial Cellulose with Strontium Apatite for Bone RegenerationAna Lorena de Brito Soares0Erika Patrícia Chagas Gomes Luz1Igor Iuco Castro-Silva2Rodolpho Ramilton de Castro Monteiro3Fábia Karine Andrade4Rodrigo Silveira Vieira5Department of Chemical Engineering, Block 709, Federal University of Ceará (UFC), Fortaleza 60455-760, CE, BrazilDepartment of Chemical Engineering, Block 709, Federal University of Ceará (UFC), Fortaleza 60455-760, CE, BrazilDental School, Federal University of Ceará (UFC), Sobral 62010-820, CE, BrazilDepartment of Chemical Engineering, Block 709, Federal University of Ceará (UFC), Fortaleza 60455-760, CE, BrazilDepartment of Chemical Engineering, Block 709, Federal University of Ceará (UFC), Fortaleza 60455-760, CE, BrazilDepartment of Chemical Engineering, Block 709, Federal University of Ceará (UFC), Fortaleza 60455-760, CE, BrazilRejections of commercial bone implants have driven research in the biomaterials field to develop more biocompatible and less cytotoxic alternatives. This study aims to create composites based on oxidized bacterial cellulose (OBC) and strontium apatite (SrAp). These composites were produced through a biomimetic method using a simulated body fluid modified with strontium ions to enhance bioactivity and stabilize apatite within the biomaterial. The incorporation of SrAp into OBC membranes was confirmed by infrared spectroscopy and indicated by the appearance of a peak corresponding to phosphate group elongation (850 cm<sup>−1</sup>). Quantification of strontium content by atomic absorption spectrometry revealed a concentration of 3359 ± 727 mg·g<sup>−1</sup> of Sr adsorbed onto the material surface after 7 days, beyond which no significant increase was observed. Scanning electron microscopy verified biomineralization through structural modifications, and X-ray diffraction showed that despite new peak appearances, the biomineralized membranes retained crystallinity similar to pure samples. The composite also demonstrated high cell viability for mouse osteoblasts and fibroblasts and a low mortality rate in brine shrimp Artemia (approximately 12.94 ± 4.77%). These findings suggest that these membranes have great potential for application in bone tissue engineering.https://www.mdpi.com/2673-4176/6/1/23oxidized bacterial cellulosebiomaterialstrontium apatite |
| spellingShingle | Ana Lorena de Brito Soares Erika Patrícia Chagas Gomes Luz Igor Iuco Castro-Silva Rodolpho Ramilton de Castro Monteiro Fábia Karine Andrade Rodrigo Silveira Vieira Composite Based on Biomineralized Oxidized Bacterial Cellulose with Strontium Apatite for Bone Regeneration Polysaccharides oxidized bacterial cellulose biomaterial strontium apatite |
| title | Composite Based on Biomineralized Oxidized Bacterial Cellulose with Strontium Apatite for Bone Regeneration |
| title_full | Composite Based on Biomineralized Oxidized Bacterial Cellulose with Strontium Apatite for Bone Regeneration |
| title_fullStr | Composite Based on Biomineralized Oxidized Bacterial Cellulose with Strontium Apatite for Bone Regeneration |
| title_full_unstemmed | Composite Based on Biomineralized Oxidized Bacterial Cellulose with Strontium Apatite for Bone Regeneration |
| title_short | Composite Based on Biomineralized Oxidized Bacterial Cellulose with Strontium Apatite for Bone Regeneration |
| title_sort | composite based on biomineralized oxidized bacterial cellulose with strontium apatite for bone regeneration |
| topic | oxidized bacterial cellulose biomaterial strontium apatite |
| url | https://www.mdpi.com/2673-4176/6/1/23 |
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