Advances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple Sclerosis
The discovery of the T helper (Th) 17 lineage, involved in the protection against fungal and extracellular bacterial infections, has profoundly revolutionized our current understanding of T cell-mediated responses in autoimmune diseases, including multiple sclerosis (MS). Indeed, recent data demonst...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/475158 |
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| author | Elisabetta Volpe Luca Battistini Giovanna Borsellino |
| author_facet | Elisabetta Volpe Luca Battistini Giovanna Borsellino |
| author_sort | Elisabetta Volpe |
| collection | DOAJ |
| description | The discovery of the T helper (Th) 17 lineage, involved in the protection against fungal and extracellular bacterial infections, has profoundly revolutionized our current understanding of T cell-mediated responses in autoimmune diseases, including multiple sclerosis (MS). Indeed, recent data demonstrate the pathogenic role of Th17 cells in autoimmune disorders. In particular, studies in MS and in its animal model (EAE, experimental autoimmune encephalomyelitis) have revealed a crucial role of Th17 cells in the pathogenesis of autoimmune demyelinating diseases in both mice and humans. Over the past years, several important aspects concerning Th17 cells have been elucidated, such as the factors which promote or inhibit their differentiation and the effector cytokines which mediate their responses. The identification of the features endowing Th17 cells with high pathogenicity in MS is of particular interest, and discoveries in Th17 cell biology and function could lead to the design of new strategies aimed at modulating the immune response in MS. Here, we will discuss recent advances in this field, with particular focus on the mechanisms conferring pathogenicity in MS and their potential modulation. |
| format | Article |
| id | doaj-art-f426f69776ad473eaea5d14d971bdf73 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-f426f69776ad473eaea5d14d971bdf732025-02-03T06:13:53ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/475158475158Advances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple SclerosisElisabetta Volpe0Luca Battistini1Giovanna Borsellino2Neuroimmunology Unit, Santa Lucia Foundation, Via del Fosso di Fiorano 64-65, 00143 Rome, ItalyNeuroimmunology Unit, Santa Lucia Foundation, Via del Fosso di Fiorano 64-65, 00143 Rome, ItalyNeuroimmunology Unit, Santa Lucia Foundation, Via del Fosso di Fiorano 64-65, 00143 Rome, ItalyThe discovery of the T helper (Th) 17 lineage, involved in the protection against fungal and extracellular bacterial infections, has profoundly revolutionized our current understanding of T cell-mediated responses in autoimmune diseases, including multiple sclerosis (MS). Indeed, recent data demonstrate the pathogenic role of Th17 cells in autoimmune disorders. In particular, studies in MS and in its animal model (EAE, experimental autoimmune encephalomyelitis) have revealed a crucial role of Th17 cells in the pathogenesis of autoimmune demyelinating diseases in both mice and humans. Over the past years, several important aspects concerning Th17 cells have been elucidated, such as the factors which promote or inhibit their differentiation and the effector cytokines which mediate their responses. The identification of the features endowing Th17 cells with high pathogenicity in MS is of particular interest, and discoveries in Th17 cell biology and function could lead to the design of new strategies aimed at modulating the immune response in MS. Here, we will discuss recent advances in this field, with particular focus on the mechanisms conferring pathogenicity in MS and their potential modulation.http://dx.doi.org/10.1155/2015/475158 |
| spellingShingle | Elisabetta Volpe Luca Battistini Giovanna Borsellino Advances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple Sclerosis Mediators of Inflammation |
| title | Advances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple Sclerosis |
| title_full | Advances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple Sclerosis |
| title_fullStr | Advances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple Sclerosis |
| title_full_unstemmed | Advances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple Sclerosis |
| title_short | Advances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple Sclerosis |
| title_sort | advances in t helper 17 cell biology pathogenic role and potential therapy in multiple sclerosis |
| url | http://dx.doi.org/10.1155/2015/475158 |
| work_keys_str_mv | AT elisabettavolpe advancesinthelper17cellbiologypathogenicroleandpotentialtherapyinmultiplesclerosis AT lucabattistini advancesinthelper17cellbiologypathogenicroleandpotentialtherapyinmultiplesclerosis AT giovannaborsellino advancesinthelper17cellbiologypathogenicroleandpotentialtherapyinmultiplesclerosis |