PGL-EXPO feasibility study of exposure to SDHi fungicides and risk of hereditary SDHx paraganglioma or pheochromocytoma

PGL-EXPO feasibility study of exposure to SDHi fungicides and risk of hereditary SDHx paraganglioma or pheochromocytoma

Abstract Paraganglioma and pheochromocytoma (PPGL) are rare neuroendocrine tumors with a strong genetic component. SDHx genes are well-known PPGL susceptibility genes. A role of environmental factors, such as succinate dehydrogenase inhibitor (SDHi) fungicides, is suspected in PPGL tumorigenesis. We...

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Bibliographic Details
Main Authors: Astrid Coste, Alexandre Buffet, Margaux Duboeuf, Sabrina Boudif, Lény Grassot, Boutheina Ouelaa, Annabelle Sueur, Timgad Lounis, Olivia Pérol, Béatrice Fervers, Anne-Paule Gimenez-Roqueplo
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
SDHi fungicides
Hereditary paraganglioma
SDH gene
Case-control study
Feasibility study
Online Access:https://doi.org/10.1038/s41598-025-09166-w
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