Myostatin Levels and the Risk of Myopenia and Rheumatoid Cachexia in Women with Rheumatoid Arthritis
Background. Myostatin is a regulator of muscle size. To date, there have been no published studies focusing on the relation between myostin levels and myopenia in rheumatoid arthritis (RA). Objective. Evaluate the value of serum myostatin as a biomarker of cachexia and low skeletal muscle mass (LSMM...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/7258152 |
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| author | Fabiola Gonzalez-Ponce Jorge Ivan Gamez-Nava Eli Efrain Gomez-Ramirez Melissa Ramirez-Villafaña Heriberto Jacobo-Cuevas Norma Alejandra Rodriguez-Jimenez Eva Maria Olivas-Flores Yussef Esparza-Guerrero Alejandro Martelli-García Aline Priscilla Santiago-Garcia Cesar Arturo Nava-Valdivia Alejandra Martinez-Hernandez Sergio Antonio Gonzalez-Vazquez Alfredo Celis Carlos Enrique Cabrera-Pivaral Sylvia Totsuka-Sutto Ernesto German Cardona-Muñoz Laura Gonzalez-Lopez |
| author_facet | Fabiola Gonzalez-Ponce Jorge Ivan Gamez-Nava Eli Efrain Gomez-Ramirez Melissa Ramirez-Villafaña Heriberto Jacobo-Cuevas Norma Alejandra Rodriguez-Jimenez Eva Maria Olivas-Flores Yussef Esparza-Guerrero Alejandro Martelli-García Aline Priscilla Santiago-Garcia Cesar Arturo Nava-Valdivia Alejandra Martinez-Hernandez Sergio Antonio Gonzalez-Vazquez Alfredo Celis Carlos Enrique Cabrera-Pivaral Sylvia Totsuka-Sutto Ernesto German Cardona-Muñoz Laura Gonzalez-Lopez |
| author_sort | Fabiola Gonzalez-Ponce |
| collection | DOAJ |
| description | Background. Myostatin is a regulator of muscle size. To date, there have been no published studies focusing on the relation between myostin levels and myopenia in rheumatoid arthritis (RA). Objective. Evaluate the value of serum myostatin as a biomarker of cachexia and low skeletal muscle mass (LSMM) in RA patients, along with whether high serum myostatin is associated to these conditions after adjusting for potential confounders. Methods. This cross-sectional study included 161 female RA patients and 72 female controls. In the RA group, we assessed several potential risk factors for LSMM and rheumatoid cachexia. Dual-energy X-ray absorptiometry was used to quantify the skeletal muscle mass index (SMMI) (considering LSMM≤5.5 kg/m2) and the presence of rheumatoid cachexia (a fat-free mass index≤10 percentile and fat mass index≥25 percentile of the reference population). Serum myostatin concentrations were determined by ELISA. To identify a cut-off for high serum myostatin levels, we performed ROC curve analysis. Multivariable logistic regression analysis was used to identify the risk factors for LSMM and rheumatoid cachexia. The risk was expressed as odds ratios (ORs) and their 95% confidence intervals (95% CIs). Results. Compared to the controls, the RA group had a higher proportion of LSMM and exhibited high serum myostatin levels (p<0.001). ROC curve analysis showed that a myostatin level≥17 ng/mL was the most efficient cut-off for identifying rheumatoid cachexia (sensitivity: 53%, specificity: 71%) and LSMM (sensitivity: 43%, specificity: 77%). In the multivariable logistic regression, RA with high myostatin levels (≥17 ng/mL) was found to increase the risk of cachexia (OR=2.79, 95% CI: 1.24-6.29; p=0.01) and LSMM (OR=3.04, 95% CI: 1.17-7.89; p=0.02). Conclusions. High serum myostatin levels increase the risk of LSMM and rheumatoid cachexia. We propose that high myostatin levels are useful biomarkers for the identification of patients in risk of rheumatoid cachexia and myopenia. |
| format | Article |
| id | doaj-art-f4185e5c6c6649e1a904fbe46b521916 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-f4185e5c6c6649e1a904fbe46b5219162025-02-03T05:49:59ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/7258152Myostatin Levels and the Risk of Myopenia and Rheumatoid Cachexia in Women with Rheumatoid ArthritisFabiola Gonzalez-Ponce0Jorge Ivan Gamez-Nava1Eli Efrain Gomez-Ramirez2Melissa Ramirez-Villafaña3Heriberto Jacobo-Cuevas4Norma Alejandra Rodriguez-Jimenez5Eva Maria Olivas-Flores6Yussef Esparza-Guerrero7Alejandro Martelli-García8Aline Priscilla Santiago-Garcia9Cesar Arturo Nava-Valdivia10Alejandra Martinez-Hernandez11Sergio Antonio Gonzalez-Vazquez12Alfredo Celis13Carlos Enrique Cabrera-Pivaral14Sylvia Totsuka-Sutto15Ernesto German Cardona-Muñoz16Laura Gonzalez-Lopez17Programa de Doctorado en FarmacologíaPrograma de Doctorado en FarmacologíaPrograma de Doctorado en FarmacologíaPrograma de Doctorado en FarmacologíaPrograma de Doctorado en FarmacologíaPrograma de Doctorado en FarmacologíaPrograma de Doctorado en FarmacologíaPrograma de Doctorado en FarmacologíaPrograma de Doctorado en FarmacologíaPrograma de Doctorado en FarmacologíaDepartamento de Microbiologia y PatologíaPrograma de Doctorado en FarmacologíaPrograma de Doctorado en FarmacologíaDivisión de Disciplinas para el DesarrolloDivisión de Disciplinas para el DesarrolloInstituto de Terapeutica Experimental y ClínicaInstituto de Terapeutica Experimental y ClínicaPrograma de Doctorado en FarmacologíaBackground. Myostatin is a regulator of muscle size. To date, there have been no published studies focusing on the relation between myostin levels and myopenia in rheumatoid arthritis (RA). Objective. Evaluate the value of serum myostatin as a biomarker of cachexia and low skeletal muscle mass (LSMM) in RA patients, along with whether high serum myostatin is associated to these conditions after adjusting for potential confounders. Methods. This cross-sectional study included 161 female RA patients and 72 female controls. In the RA group, we assessed several potential risk factors for LSMM and rheumatoid cachexia. Dual-energy X-ray absorptiometry was used to quantify the skeletal muscle mass index (SMMI) (considering LSMM≤5.5 kg/m2) and the presence of rheumatoid cachexia (a fat-free mass index≤10 percentile and fat mass index≥25 percentile of the reference population). Serum myostatin concentrations were determined by ELISA. To identify a cut-off for high serum myostatin levels, we performed ROC curve analysis. Multivariable logistic regression analysis was used to identify the risk factors for LSMM and rheumatoid cachexia. The risk was expressed as odds ratios (ORs) and their 95% confidence intervals (95% CIs). Results. Compared to the controls, the RA group had a higher proportion of LSMM and exhibited high serum myostatin levels (p<0.001). ROC curve analysis showed that a myostatin level≥17 ng/mL was the most efficient cut-off for identifying rheumatoid cachexia (sensitivity: 53%, specificity: 71%) and LSMM (sensitivity: 43%, specificity: 77%). In the multivariable logistic regression, RA with high myostatin levels (≥17 ng/mL) was found to increase the risk of cachexia (OR=2.79, 95% CI: 1.24-6.29; p=0.01) and LSMM (OR=3.04, 95% CI: 1.17-7.89; p=0.02). Conclusions. High serum myostatin levels increase the risk of LSMM and rheumatoid cachexia. We propose that high myostatin levels are useful biomarkers for the identification of patients in risk of rheumatoid cachexia and myopenia.http://dx.doi.org/10.1155/2022/7258152 |
| spellingShingle | Fabiola Gonzalez-Ponce Jorge Ivan Gamez-Nava Eli Efrain Gomez-Ramirez Melissa Ramirez-Villafaña Heriberto Jacobo-Cuevas Norma Alejandra Rodriguez-Jimenez Eva Maria Olivas-Flores Yussef Esparza-Guerrero Alejandro Martelli-García Aline Priscilla Santiago-Garcia Cesar Arturo Nava-Valdivia Alejandra Martinez-Hernandez Sergio Antonio Gonzalez-Vazquez Alfredo Celis Carlos Enrique Cabrera-Pivaral Sylvia Totsuka-Sutto Ernesto German Cardona-Muñoz Laura Gonzalez-Lopez Myostatin Levels and the Risk of Myopenia and Rheumatoid Cachexia in Women with Rheumatoid Arthritis Journal of Immunology Research |
| title | Myostatin Levels and the Risk of Myopenia and Rheumatoid Cachexia in Women with Rheumatoid Arthritis |
| title_full | Myostatin Levels and the Risk of Myopenia and Rheumatoid Cachexia in Women with Rheumatoid Arthritis |
| title_fullStr | Myostatin Levels and the Risk of Myopenia and Rheumatoid Cachexia in Women with Rheumatoid Arthritis |
| title_full_unstemmed | Myostatin Levels and the Risk of Myopenia and Rheumatoid Cachexia in Women with Rheumatoid Arthritis |
| title_short | Myostatin Levels and the Risk of Myopenia and Rheumatoid Cachexia in Women with Rheumatoid Arthritis |
| title_sort | myostatin levels and the risk of myopenia and rheumatoid cachexia in women with rheumatoid arthritis |
| url | http://dx.doi.org/10.1155/2022/7258152 |
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