Enhancing lung transplantation with ECMO: a comprehensive review of mechanisms, outcomes, and future considerations
Background: Lung transplantation (LTx) is a critical intervention for patients with end-stage lung disease. However, challenges such as donor organ scarcity and post-transplant complications significantly affect its success. Recent advancements in Extracorporeal Membrane Oxygenation (ECMO) have show...
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EDP Sciences
2024-12-01
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| Series: | The Journal of ExtraCorporeal Technology |
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| Online Access: | https://ject.edpsciences.org/articles/ject/full_html/2024/04/ject240026/ject240026.html |
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| author | Pervaiz Butt Salman Kakar Vivek Abdulaziz Salman Razzaq Nabeel Saleem Yasir Kumar Arun Ashiq Fazil Ghisulal Praveen Thrush Aaron Malik Sadaf Griffin Mairead Amir Mahanoor Khan Umar Salim Ashal Zoumot Zaid Mydin Izanee Aljabery Yazan Bhatnagar Gopal Bayrak Yusuf Obeso Andres Ahmed Usman |
| author_facet | Pervaiz Butt Salman Kakar Vivek Abdulaziz Salman Razzaq Nabeel Saleem Yasir Kumar Arun Ashiq Fazil Ghisulal Praveen Thrush Aaron Malik Sadaf Griffin Mairead Amir Mahanoor Khan Umar Salim Ashal Zoumot Zaid Mydin Izanee Aljabery Yazan Bhatnagar Gopal Bayrak Yusuf Obeso Andres Ahmed Usman |
| author_sort | Pervaiz Butt Salman |
| collection | DOAJ |
| description | Background: Lung transplantation (LTx) is a critical intervention for patients with end-stage lung disease. However, challenges such as donor organ scarcity and post-transplant complications significantly affect its success. Recent advancements in Extracorporeal Membrane Oxygenation (ECMO) have shown promise in improving the outcomes and expanding eligibility for LTx. Methods: A comprehensive literature review was conducted, focusing on studies that explore the use of ECMO in lung transplantation. A thorough search of relevant studies on ECMO and LTx was conducted using multiple scholarly databases and relevant keywords, resulting in 73 studies that met the inclusion criteria. Sources included peer-reviewed journals and clinical trial results, with emphasis on articles captured recent advancements in ECMO technology and techniques. Results: ECMO has been crucial in supporting patients before, during, and after LTx. It serves as a bridge to transplantation by maintaining pulmonary and circulatory stability in critically ill patients awaiting donor organs. ECMO also aids in the evaluation of marginal donor lungs and supports patients through acute post-transplant complications. Recent technological advancements have improved the safety and efficacy of ECMO, further solidifying its role in LTx. Conclusion: In conclusion, this review underscores ECMO's critical role in enhancing outcomes across all stages of lung transplantation. Its various configurations and strategies have shown promise in stabilizing critically ill patients and improving transplant success rates. Looking ahead, it’s important to gather more information about the long-term outcomes and potential complications associated with ECMO use. More research and data collection will help us understand the benefits and risks better, leading to improved decision-making and patient care in this field. |
| format | Article |
| id | doaj-art-f410fc93f5fc4457aae0bf9a72d4c2c5 |
| institution | Kabale University |
| issn | 0022-1058 2969-8960 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | The Journal of ExtraCorporeal Technology |
| spelling | doaj-art-f410fc93f5fc4457aae0bf9a72d4c2c52025-01-08T11:00:21ZengEDP SciencesThe Journal of ExtraCorporeal Technology0022-10582969-89602024-12-0156419120210.1051/ject/2024023ject240026Enhancing lung transplantation with ECMO: a comprehensive review of mechanisms, outcomes, and future considerationsPervaiz Butt Salman0Kakar Vivek1Abdulaziz Salman2Razzaq Nabeel3Saleem Yasir4Kumar Arun5Ashiq Fazil6Ghisulal Praveen7Thrush Aaron8Malik Sadaf9Griffin Mairead10Amir Mahanoor11Khan Umar12Salim Ashal13Zoumot Zaid14Mydin Izanee15Aljabery Yazan16Bhatnagar Gopal17Bayrak Yusuf18Obeso Andres19Ahmed Usman20Interim Manager Perfusion Services, Heart Vascular and Thoracic Institute, Cleveland ClinicDirector ECMO Program, Critical Care InstituteConsultant of Cardiovascular Critical Care, Co-Chair of ECMO Task Force, Department of HealthClinical Perfusionist, Heart Vascular and Thoracic Institute, Cleveland ClinicPerfusionist, All India Institute of Medical SciencesDepartment Chair, Cardiothoracic Aesthesia, Anesthesiology Institute, Cleveland ClinicAnesthesiology Physician, Anesthesiology Institute, Cleveland ClinicCritical Care Associate Staff Physician, Critical Care InstitutePhysical Therapist, Critical Care InstitutePhysician Assistant, Critical Care InstituteNurse Manager, Heart Vascular and Thoracic Institute, Cleveland ClinicPhysical Therapist, Shalimar Medical and Dental CollegeCritical Care Consultant, Critical Care InstituteCharge Nurse, Critical Care InstituteDepartment Chair Pulmonology, Pulmonology InstituteConsultant Transplant Surgeon, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Freeman HospitalAssociate Staff Physician, Heart Vascular and Thoracic Institute, Cleveland ClinicInstitute Chair, Heart Vascular and Thoracic Institute, Cleveland ClinicThoracic Physician, Heart Vascular and Thoracic Institute, Cleveland ClinicThoracic Physician, Heart Vascular and Thoracic Institute, Cleveland ClinicDepartmental Chair Thoracic Surgery, Heart Vascular and Thoracic Institute, Cleveland ClinicBackground: Lung transplantation (LTx) is a critical intervention for patients with end-stage lung disease. However, challenges such as donor organ scarcity and post-transplant complications significantly affect its success. Recent advancements in Extracorporeal Membrane Oxygenation (ECMO) have shown promise in improving the outcomes and expanding eligibility for LTx. Methods: A comprehensive literature review was conducted, focusing on studies that explore the use of ECMO in lung transplantation. A thorough search of relevant studies on ECMO and LTx was conducted using multiple scholarly databases and relevant keywords, resulting in 73 studies that met the inclusion criteria. Sources included peer-reviewed journals and clinical trial results, with emphasis on articles captured recent advancements in ECMO technology and techniques. Results: ECMO has been crucial in supporting patients before, during, and after LTx. It serves as a bridge to transplantation by maintaining pulmonary and circulatory stability in critically ill patients awaiting donor organs. ECMO also aids in the evaluation of marginal donor lungs and supports patients through acute post-transplant complications. Recent technological advancements have improved the safety and efficacy of ECMO, further solidifying its role in LTx. Conclusion: In conclusion, this review underscores ECMO's critical role in enhancing outcomes across all stages of lung transplantation. Its various configurations and strategies have shown promise in stabilizing critically ill patients and improving transplant success rates. Looking ahead, it’s important to gather more information about the long-term outcomes and potential complications associated with ECMO use. More research and data collection will help us understand the benefits and risks better, leading to improved decision-making and patient care in this field.https://ject.edpsciences.org/articles/ject/full_html/2024/04/ject240026/ject240026.htmllung transplantation (ltx)ecmo (extracorporeal membrane oxygenator)primary graft dysfunction (pgd)cardiopulmonary bypass (cpb) |
| spellingShingle | Pervaiz Butt Salman Kakar Vivek Abdulaziz Salman Razzaq Nabeel Saleem Yasir Kumar Arun Ashiq Fazil Ghisulal Praveen Thrush Aaron Malik Sadaf Griffin Mairead Amir Mahanoor Khan Umar Salim Ashal Zoumot Zaid Mydin Izanee Aljabery Yazan Bhatnagar Gopal Bayrak Yusuf Obeso Andres Ahmed Usman Enhancing lung transplantation with ECMO: a comprehensive review of mechanisms, outcomes, and future considerations The Journal of ExtraCorporeal Technology lung transplantation (ltx) ecmo (extracorporeal membrane oxygenator) primary graft dysfunction (pgd) cardiopulmonary bypass (cpb) |
| title | Enhancing lung transplantation with ECMO: a comprehensive review of mechanisms, outcomes, and future considerations |
| title_full | Enhancing lung transplantation with ECMO: a comprehensive review of mechanisms, outcomes, and future considerations |
| title_fullStr | Enhancing lung transplantation with ECMO: a comprehensive review of mechanisms, outcomes, and future considerations |
| title_full_unstemmed | Enhancing lung transplantation with ECMO: a comprehensive review of mechanisms, outcomes, and future considerations |
| title_short | Enhancing lung transplantation with ECMO: a comprehensive review of mechanisms, outcomes, and future considerations |
| title_sort | enhancing lung transplantation with ecmo a comprehensive review of mechanisms outcomes and future considerations |
| topic | lung transplantation (ltx) ecmo (extracorporeal membrane oxygenator) primary graft dysfunction (pgd) cardiopulmonary bypass (cpb) |
| url | https://ject.edpsciences.org/articles/ject/full_html/2024/04/ject240026/ject240026.html |
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